10th anniversary International Multiconference «Bioinformatics of Genome Regulation and Structure\ Systems Biology»

Siberian supercomputer center as a service for bioinformatics research

Igor Chernykh, B. Glinskiy, N. Kuchin

Institute of Computational Mathematics and Mathematical Geophysics SB RAS, Novosibirsk, Russia

09:45−10:05

Approaches to personalized cell therapy for ischemic diseases Olga Poveshchenko SICEL, Novosibirsk, Russia

9:45–10:00

HLA typing pipeline for amplicon sequencing Olga Altukhova, P.I. Borovikov^1, Т. Jankevi^2, I.S. Balashov^1 ^1Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Moscow, Russia; ^2NRC Institute of Immunology FMBA of Russia, Moscow, Russia

10.00–10.30

Single cell expression profiling of neural crest-derived cells Tatiana Subkhankulova^1, G. Aquino^2, A. Rocco^2, H. Schwetlick^1, R.N. Kelsh^1 ^1Department of Biology and Biochemistry, University of Bath, Bath, UK; ^2Department of Microbial and Cellular Sciences, University of Surrey, Guildford, UK

10:00–10:30

Engineering and neurocognitive aspects in the development of non-invasive brain-computer interfaces Sergei Shishkin^1 ^1National Research Centre "Kurchatov Institute", Moscow, Russia

10:05−10:20

Clinical efficacy of biomedical cellular products in experimental bowel inflammation disease Alexander Lykov, N.A. Bondarenko, M.A. Surovtseva, I.I. Kim, N.P. Bgatova, O.V. Poveshchenko SICEL, Novosibirsk, Russia

10:00–10:15

High-performance intelligent analysis of biomechanical processes control and management of blood pressure in human kidney Agyn Bedelbayev Al-Farabi Kazakh National University, Almaty, Kazakhstan

10:20−10:35

Strategies for maturation and antigen loading of dendritic cells for anti-cancer immunotherapy Zhanna Nazarkina^1,2, A. Zajakina ^3, P.P. Laktionov ^1,2 ^1ICBFMSB RAS, Novosibirsk, Russia; ^2Scientific Research Institute for Circulatory Pathology named after Academician E.N. Meshalkin, Novosibirsk, Russia; ^3Latvian Biomedical Research and Study Centre, Riga, Latvia

10:15–10:30

High-performance computations support for the software package «haplooid evolutionary constructor» Roman Zudin^1,2, S.A. Lashin^1,2 ^1ICG SB RAS, Novosibirsk, Russia; ^2NSU, Novosibirsk, Russia

10.30–10.45

Using Dolomite Microfluidics for sequencing the transcriptome of individual cells Dmitry Brittal LLC "Dia M", Moscow, Russia

10:30–10:50

Abductive reasoning in psychotherapy Vladimir Zavyalov^1 ^1Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia

10:35−10:50

Discussion

10:30–10:45

Argo-CUDA: a full-exhaustive GPU based approach for a motif discovery in the large DNA datasets Oleg Vishnevsky^1,2, A.V. Bocharnikov^2, N.A. Kolchanov^1,2 ^1ICG SB RAS, Novosibirsk, Russia; ^2NSU, Novosibirsk, Russia

Coffee break: 10.55–11.10

11.10–11.25

Genome of black garden ant: defense against virus invasion? E.A. Konorov, Victoria Scobeyeva, M.A. Nikitin, S.N. Lysenkov, S. Nuzhdin Moscow State University, Moscow, Russia

11.00-16.00

Section “Bioinformatics and Systems Biology of Cell Death” Chairpersons: Inna Lavrik, Otto von Guericke University, Magdeburg, Germany

11:10–11:30

Connection of genetic and endophenotypic indexes with personality properties of the healthy participants and the patients with affective pathologies Alexander Savostyanov^1 ^1 Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia

11:10−13:00

Translational Medicine: from Animal Models to Clinic Chairs: Michael Moshkin, Andrei Akulov

11:10–15:50

Afternoon session “Application of Bioinformatics and Systems Biology” Chairperson: Alexander Marchuk, Vladimir Ivanisenko, Alexander Kel

11.25-11.40

Target enrichment technologies for applied research Dmitry Kwon Agilent Technologies Russia, Moscow, Russia

11.00–11.40

The p53 family in cancer biology I. Amelio^1, F. Bernassola^2, T.W. Mak^2, Gerry Melino^1^,3 ^1MRC Toxicology Unit, LeicesterLE1 9HN, United Kingdom; ^2The Campbell Family Cancer Research Institute, Toronto, Ontario M5G 2M9, Canada ^3University of Rome Tor Vergata, Rome, Italy

11:30–11:50

Artificial neural network for diagnosis of cognitive impairment in children with different clinical forms of perinatal lesions of the central nervous system Alexey Pijanzin^1,2,3, Ashkinadze A.V.^2, Shaidurov A.A.^1, Ivchenko E.V.^3 ^1Altai State University, Barnaul, Russia; ^2 Altai State Medical University, Barnaul, Russia; ^3 Altai Region Clinical Children’s Hospital, Barnaul, Russia

11:10−11:30

Genetic diversity of laboratory animals in translational research Eugenii Zavjalov Institute of Cytology and Genetics of SB RAS, Novosibirsk, Russia

11:10–11:40

ANDSYSTEM: an internet-accessible tool for automated literature mining in the area of biology Vladimir Ivanisenko^1,2, O.V. Saik^1,2, E.S. Tiys^1, T.V. Ivanisenko^1,2, P.S. Demenkov^1,2 ^1Institute of Cytology and Genetics RAS, Novosibirsk, Russia ^2PB-soft LLC, Novosibirsk, Russia

11.40–12.10

HOCOMOCO COmprehensive MOdel COllection as a practical gateway to regulatory motif-ome of human and mouse transcription factors I.E. Vorontsov, Y.A. Medvedeva, V.J. Makeev, Ivan Kulakovskiy Vavilov Institute of General Genetics, Moscow, Russia; Engelhardt Institute of Molecular Biology, Moscow, Russia

11.40–12.10

Chemoresistance of lung adenocarcinoma is regulated by Tudor staphylococcal nuclease Boris Zhivotovsky^1,2 ^1Lomonosov Moscow State University, Moscow, Russia ^2Karolinska Institutet, Stockholm, Sweden

11:50–12:10

Prospects of development of neuroimaging technologies in modern medicine Andrey Letyagin^1,2 ^1Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia ^2Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia

11:30–11:45

Effects of the complex of melatonin, aluminium oxide and polymethylsiloxane on the liver structure in type 2 diabetic mice Svetlana Michurina^1, I.Yu. Isсhenko^1, V.V. Klimontov^1, S.A. Archipov^1, M.A. Cherepanova^1, L.N. Rachkovskaya^1, N.E. Myakina^1, E.L. Zavjalov^2, V.I. Konenkov^1, Yu.I. Borodin^1, M.A. Korolev^1 ^1SICEL, Novosibirsk, Russia; ^2ICG SB RAS, Novosibirsk, Russia

11:40–11:55

UGENE: a toolkit for teaching students Irina Bykova^1, O.I. Golosova^1, A.Y. Bakulina^2,3, D.A. Afonnikov^2,4, D.Y. Kandrov^1, A.Y. Palyanov^2,5, G.A. Grekhov^1, Y.E. Danilova^1 ^1Unipro Center of Information Technologies, Novosibirsk, Russia; ^2NSU, Novosibirsk, Russia; ^3State Research Center of Virology and Biotechnology VECTOR, Koltsovo, Novosibirsk region, Russia; ^4ICG SB RAS, Novosibirsk, Russia ^5Institute of Informatics Systems SB RAS, Novosibirsk, Russia

12.10–12.40

Regulatory role of single CpG methylation A. Khamis^1, A.V. Artemov^2, A.V. Lioznova^2, V.B. Bajic^1, Yulija Medvedeva^2 ^1King Abdullah University of Science and Technology ^2Research Center of Biotechnology RAS

12.10–12.40

The role of kinetochore-driven microtubule formation in Drosophila spindle assembly G. Pavlova^1,2,*, J. Popova^1,3,*, A. Munzarova^1,4,*, J. Galimova^1,*, A. Razuvaeva^1,4, F. Renda^5, P. Somma^5, A. Pindyurin^1,4, Maurizio Gatti^5 ^1Institute of Molecular and Cellular Biology, Novosibirsk, Russia; ^2Kazan Federal University, Kazan, Russia; ^3Institute of Cytology and Genetics, Novosibirsk, Russia ^4NSU, Novosibirsk, Russia; ^5Department of Biology and Biotechnology, Sapienza, University of Rome, Rome, Italy

12:10–12:30

Molecular mechanisms underlying the cognitive functions of the neuron Alexander Ratushnyak^1, Zapara T.A.^1, Proskura A.L.^1, Sorokoumov E.D.^1 ^1Institute of Computational Technologies of SB RAS, Novosibirsk, Russia

11:45−12:05

Brain metabolites under deficiency of the available energy Andrei Akulov^1, D.A. Tur^2, R.G. Gulevich^1, E.D. Petrovskiy^1,3, M.P.Moshkin^1 ^1ICG SB RAS, Novosibirsk, Russia; ^2NSU, Novosibirsk, Russia; ^3International Tomography Center SB RAS, Novosibirsk, Russia

11:55–12:10

A software tool for visualization and control of biological neural networks activity based on the neuron simulation environment Sergey Khayrulin^1,2, N.A. Serdtseva^2, A.Yu. Palyanov^1,2 ^1Institute of Informatics Systems SB RAS, Novosibirsk, Russia; ^2NSU, Novosibirsk, Russia

12:05−12:20

Biological effects of lithium nanoparticles Nataliya Bgatova SICEL, Novosibirsk, Russia

12:10–12:25

Haploid evolutionary constructor 3D: a framework for multilayer modeling of spatially distributed microbial communities Sergey Lashin^1,2, A.I. Klimenko^1,2, Yu.G. Matushkin^1,2, Z.S. Mustafin^1,2, A.D. Chekantsev^1,2, R.K. Zudin^1,2 ^1Institute of Cytology and Genetics RAS, Novosibirsk, Russia ^2NSU, Novosibirsk, Russia

12.40–12.55

Ampliseq ™: amplification and sequencing Ilya Volkov Department of scientific and methodological support of "Khimexpert Agency", Moscow, Russia

12.40–13.00

Involvement of various cell death modalities in cytotoxic activity of lactaptin analog Olga Koval^1,2, G.V. Kochneva^1,3, A.V. Tkachenko^1, O.S. Troitskaya^1,2, G.F. Sivolobova^1,3, E.V. Kuligina^1, A.Y. Yunusova^1, V.A. Richter^1 ^1ICBFM SB RAS, Novosibirsk, Russia; ^2NSU, Novosibirsk, Russia; ^3State Research Center of Virology and Biotechnology “Vector”, Koltsovo, Russia

12:30–13:00

Application neuroelectrostimulation of a peripheral nervous system for correction of cognitive characteristics in a problem of learning ability Anna Petrenko^1, Kublanov V.S.^1 ^1 Research Medical and Biological Engineering Center of High Technologies Ural Federal University, Yekaterinburg, Russia

12:20−12:35

Theranostic nanoplatforms for simultaneous cancer imaging and therapy: Multifunctional nanoassemblies of human serum albumin and therapeutic nucleotides Tatyana Godovikova^1,4, A.E. Akulov^2, V.A. Lisitskiy^1, A.S. Chubarov^1, N.M. Antonova^1, O.D. Zakharova^1, I.V. Koptyug^3, T.V. Popova, V.I. Kaledin^2, I.A. Razumov^2, E.L. Zavjalov^2, M.P. Moshkin^2, V.N. Silnikov^1 ^1ICBFM SB RAS, Novosibirsk, Russia; ^2ICG SB RAS, Novosibirsk, Russia; ^3International Tomography Center SB RAS, Novosibirsk, Russia; ^4NSU, Novosibirsk, Russia

12:25–12:40

New image analysis and base calling algorithm for SeqLL sequencing machine achieved better sensitivity on synthetic olygonucleotides set Nikolay Russkikh^1, D.V. Antonets^2,3,4 ^1Novel Software Systems LLC, Novosibirsk, Russia ^2AcademGene LLC, Novosibirsk, Russia; ^3A.P. Ershov Institute of informatics systems, Novosibirsk, Russia; ^4State Research Center of Virology and Biotechnology ‘Vector’, Koltsovo, Novosibirsk region, Russia

12:35−12:50

Evaluation of Demyelination in the Cuprizone Model of Multiple Sclerosis: MRI and Histology Correlation Marina Khodanovich^1, I.V. Sorokina^2, V.Yu. Glazacheva^1, N.M. Nemirovich-Danchenko^1, E.S. Pan^1, E.V. Krutenkova^1, Al.V. Romashchenko^3, A.E. Akulov^1,3, T.G. Tolstikova^2, V.L. Yarnykh^1,4 ^1Tomsk State University, Tomsk, Russia; ^2Institute of Organic Chemistry SB RAS, Novosibirsk, Russian;^3ICG SB RAS, Novosibirsk, Russia; ^4University of Washington, Seattle, USA

12:40–12:55

IT analysis of cornea endothelium transport ability in corneal transplants after hypothermic conservation Evgeniy Solenov^3, A.A. Konev^1, I.G. Palchikova^1, I.A. Iskakov^2, L.E. Katkova^3, G.S. Baturina^3 ^1Technological Design Institute of Scientific Instrument Engineering SB RAS, Novosibirsk, Russia ^2Multidisciplinary Science and Technology Complex “Eye Microsurgery” named after S.N. Fyodorov Federal State Institution, Novosibirsk Branch, Novosibirsk, Russia; ^3ICG SB RAS, Novosibirsk, Russia

12:50−13:00

Discussion

Lunch: 13.00–14.00

14.00–19.40

Section “Systems Computational Biology” Chairperson: Alexander Ratushny, Celgene, Seattle, USA and Institute for Systems Biology, Seattle, USA

14.00–14.40

Towards understanding the dynamics of death receptor networks Inna Lavrik ICG SB RAS, Novosibirsk, Russia Otto-von Guericke-University, Magdeburg, Germany

14:00 – 14:40

Genomics of behavioral diseases Evgeny Rogaev ^1ICG SB RAS, Novosibirsk, Russia; ^2Vavilov Institute of General Genetics RAS, Moscow, Russia; ^3Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts

14:00−15:50

Systems Biology in Human Health and Disease Chairs: Vyacheslav Mordvinov, Valeriy Loktev

14:00–14:15

Web-based application for flow cytometry data analysis Jitong Xue^1, Ming Chen^1, Y. Zhou^1, W Ni^2 ^1Zhejiang University, Hangzhou, China; ^2Zhejiang Provincial People’s Hospital, Hangzhou, China

14.00–14.30