10th anniversary International Multiconference «Bioinformatics of Genome Regulation and Structure\ Systems Biology»

Phage infection slows down speciation caused by gene loss and horizontal gene transfer of metabolic genes in models of spatially distributed bacterial communities

Aleksandra Klimenko, Yu.G. Matushkin, N.A. Kolchanov, S.A. Lashin

ICG SB RAS, Novosibirsk, Russia

17:10−17:25

Natural bispecific antibodies: new biochemical markers of autoimmune diseases Sergey Sedykh, V.V. Printz, V.N. Buneva, G.A. Nevinsky ICBFM SB RAS, NSU, Novosibirsk, Russia

18.00–18.15

Crossing valleys and reaching peak on the fitness landscapes in microbial communities under various ecological conditions: a simulation study Zakhar Mustafin^1, D.A. Afonnikov^1,2, Yu.G. Matushkin^1,2, S.A. Lashin^1,2 ^1ICG SB RAS; ^2NSU, Novosibirsk, Russia

17:25−17:40

Molecular basis for targeted therapy of autoimmune diseases Мaksim Korolev SICEL, Novosibirsk, Russia

18.15–18.30

Role of membrane potential in nitrite utilization by Escherichia Coli cells under low substrate concentrations: the mathematical model Natalya Ree, Likhoshvai V.A., Khlebodarova T.M. ICG SB RAS, Novosibirsk, Russia

17:40−17:55

Leukocyte telomere length as a marker of aging and a risk factor for the development of socially significant diseases in Siberia Vladimir Maksimov Institute of Internal and Preventive Medicine, Novosibirsk, Russia

18.30–18.45

Modeling restriction-modification systems: expressing toxic molecules within a cell Andjela Rodic, M. Djordjevic University of Belgrade, Belgrade, Serbia

17:55−18:00

Discussion

31 August, Wednesday (09:00-13:00)

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9.00–13.10

Section “Evolutionary Bioinformatics” Chairpersons: Fyodor Kondrashov, Evolutionary Genomics laboratory and ICREA, Barcelona, Spain

9.00–12.50

Section “Animal Genetics” (House of Scientists SB RAS, Library) Chairperson: Mikhail Moshkin, ICG SB RAS, Novosibirsk, Russia BGRS\SB

9.00 – 13.00

Symposium «Cognitive Sciences, Genomics and Bioinformatics” CSGB

Section «Personalized Medicine: from Basic Science to Clinic» SBioMED

09:00–13:00

Morning session “Analysis of dynamical systems. Identifiability” Chairpersons: Prof. Sergey Kabanikhin, Prof. H.T. Banks, Dmitriy Voronov MM-HPC-BBB-2016

9.00–9.35

Patterns and mechanisms of chromosomal evolution inferred from physically mapped genome assemblies Igor Sharakhov^1,3,4, G.N.Artemov^4, A. Peery^1, X. Jiang^3, A.B. Hall^3, Z.Tu^2,3, A.N. Naumenko^1, V.N. Stegniy^4, M.V. Sharakhova^3 ^1Virginia Polytechnic Institute and State University, Blacksburg, USA; ^2Virginia Polytechnic Institute and State University, Blacksburg, USA; ^3The PhD Program in Genomics Bioinformatics and Computational Biology, Virginia Polytechnic Institute and State University, Blacksburg, USA; ^4Tomsk State University, Tomsk, Russia.

9.00–9.35

The role of functional domains of Drosophila septin Pnut K.A.Akhmetova^1,2,3, N.V.Dorogova^1, M.L.Balasov^3, Svetlana Fedorova^1,2, I.N.Chesnokov^3 ^1ICG SB RAS, Novosibirsk, Russia ^2NSU, Novosibirsk, Russia; ^3University of Alabama at Birmingham, Birmingham, USA

9.00–9:30

Identity of the «natural» classification structure of the external world and the consciousness as integrated information by G.Tononi Evgenii Vityaev^1 ^1Sobolev Institute of Mathematics SB RAS, Novosibirsk, Russia

09:00−10:50

Genomic Technology for Personalized Medicine Chairs: Valeriy Puzyrev, Yurii Aulchenko

9:00–9:30

On a method of approximation of solutions to delay differential equations Gennadii Demidenko^1,2 ^1Sobolev Institute of Mathematics SBRAS, Novosibirsk, Russia ^2NSU, Novosibirsk, Russia

09:00−09:40

Genome-wide association studies of complex human traits: history and perspectives Yurii Aulchenko ICG SB RAS, Novosibirsk, Russia; NSU, Novosibirsk, Russia

9.35–10.00

Can long antiparallel open reading frames be encoding essential genes in prokaryotic genomes? Denis Moshenskij, A.V. Alexeevski A.N. Belozersky Institute of Physico-Chemical Biology MSU, Moscow, Russia

9.35–10.00

Virome analysis for identification of viruses in bat species from Moscow region Anna Speranskaya^1, Pimkina E.V.^1, Artyushin I.V.^2, Safonova M.V.^1, Deviatkin A.A.^1, Kuleshov K.V.^1, Dedkov V.G.^1, Shipulin G.A.^1 ^1Central Research Institute for Epidemiology, Russian Inspectorate for Protection of Consumer Right and Human Welfare, Moscow, Russia; ^2Biological Faculty, Moscow State University, Moscow, Russia

9:30–9:50

Studying human social environment and state with social network data Anton Kolonin^1 ^1 ICG SB RAS, Aigents Group, Novosibirsk, Russia

09:40−09:55

Candidate SNP markers of aggressiveness-related complications and comorbidities of hereditary diseases predicted by a significant alteration in the affinity of TATA-binding protein for human gene promoters M.P. Ponomarenko^1,2, D.A. Rasskazov^1, E.B. Sharypova^1, Irina Chadaeva^1, P.M. Ponomarenko^3, L.K. Savinkova^1, N.A. Kolchanov^1,2 ^1ICG SB RAS; ^2NSU, Novosibirsk, Russia; ^3University of Southern California, USA;

9:30–9:45

Numerical model of drosophila sensory organ precursor cell determination Vladimir Golubyatnikov^1,2, T.A.Bukharina^2, D.P.Furman^2,3, M.V.Kazantsev ^4 ^1NSU, Novosibirsk, Russia ^2Sobolev Institute of Mathematics SB RAS, Novosibirsk, Russia ^3ICG SB RAS, Novosibirsk, Russia ^4Polzunov Altai State Technical University, 656038, Barnaul, Russia

10.00–10.25

RNA-Seq data analysis of rats with aggressive behavior in three brain areas Anatoly Bragin, Markel A.L., Babenko V.N., Chadaeva I.V., Tiys E.S., Orlov Y.L. ICG SB RAS, Novosibirsk, Russia

10.00–10.25

Identification of breed-specific SNP-markers for Sus scrofa domesticus using SRA-data of NGS projects Iosif Tsybovsky, V.N. Kipen, S.A. Kotova Scientific and Practical Centre of the State Committee of Forensic Expertises, Minsk, Belarus

9:50-10:10

The opposing effects of short- and long-term social stress on prefrontal cortex transcriptome Natalia Bondar^1, Bryzgalov L.O.^1, Ershov N.E.^1,2, Gusev F.E.^2,4, Reshetnikov V.V.^1, Avgustinovich D.F.^2, Tenditnik M.V.^3, Rogaev E.I.^2,4, Merkulova T.I.^1 ^1,2ICG SB RAS; ^3 Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia; ^4University of Massachusetts Medical School, USA

Preimplanation genetic screening using NGS Irina Mukosey, E.S. Shubina, A.N. Ekimov, T.O. Kochetkova, N.V. Aleksandrova, T.A. Kodyleva, N.P. Makarova, E.V. Kulakova, L.A. Levkov, D.Yu. Trofimov, G.T. Sukhikh Research Center for Obstetrics, Gynecology and Perinatology, Moscow

9:45–10:00

On properties of solutions to some nonlinear systems with parameters Inessa Matveeva Sobolev Institute of Mathematics SBRAS, Novosibirsk, Russia

10.25–10.50

Long-term spaceflight mediated changes in promoter landscape in Zebrafish tissues Alexander Cherkasov^1, K.V. Arshavsky^1, V.N. Sychev^2, M.A. Levinskikh^2, O.A. Gusev^1,3,4 ^1Institute of Fundamental Biology and Medicine, Kazan Federal University, Kazan, Russia; ^2Institute for Biomedical Problems, Russian Academy of Sciences, Moscow, Russia; ^3Division of Genomic Technologies, CLST, RIKEN, Yokohama, Japan; ^4Preventive Medicine & Diagnosis Innovation Program, CLST, RIKEN, Yokohama, Japan

10.25–10.50

Identification of the taxa of the order Artiodactyla for criminal investigation cases of illegal hunting Iosif Tsybovsky, S.A. Kotova, V.I. Rybakova, A.A. Rabcava, E.A. Spivak Scientific and Practical Centre of the State Committee of Forensic Expertises, Minsk, Belarus

10:10–10:30

Genotype 5-HTTLPR of serotonin transporter gene in regulation of cognitive functions: interaction with gender, age, and intellectual activity Nina Volf ^1,2, Bazovkina D.V.^3 ^1 Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia ^2 NSU, Novosibirsk, Russia ^3 ICG SB RAS, Novosibirsk, Russia

10:10−10:25

GENEQUERY: globally connected networks of GEO transcriptional profiles show hypothesis generation potential and reveal that tocopherols rescue TREM2-associated microglial dysfunction Alexander Predeus^1,2, T. Ulland^1, Y. Wang^1, V. Lampropoulou^1, W. Song^1, I. Arbuzov^3, F. Towfic^4, S. Gilfilan^1, E. Loginicheva^1, B.T. Edelson^1, B. Zeskind^4, M. Colonna^1, M.N. Artyomov^1 ^1Department of Pathology & Immunology, Washington University School of Medicine, USA ^2Bioinformatics institute; ^3ITMO University, Saint Petersburg, Russia; ^4Immuneering Corporation, Cambridge, USA

10:00–10:15

Development of a method of basic trajectories of G. I. Marchuk for parametrical identification of the nonlinear differential equations Boris Shumilov Tomsk State University of Architecture and Building, Tomsk, Russia

10:15–10:30

A congestion game model for virtual drug screening in a desktop grid Natalia Nikitina, E.E. Ivashko Institute of Applied Mathematical Research, Karelian Research Center, RAS, Petrozavodsk, 185910, Russia

10:30–10:50

Towards a neurobiologically reasonable c. elegans nervous system simulation: neuron, muscle and signal propagation modelling Andrey Palyanov^1, Samoilova Kh.V. ^1 A.P. Ershov Institute of Informatics Systems, NSU, Novosibirsk, Russia

10:25−10:40

KATIS: integrative information system for complimentary medicine R. Hofestädt, V. Ogultarhan, A. Shoshi University Bielefeld, AG Bioinformatics and Medical Informatics, Bielefeld, Germany

10:30–10:45

Threshold functions recovery algorithms in discrete dynamic systems Nikolay Prytkov^1, A.L. Perezhogin^2 ^1NSU, Novosibirsk, Russia ^2Sobolev Institute of Mathematics SB RAS, Novosibirsk, Russia

10:40−10:50

Discussion

Coffee break: 10.50–11.10

11.10–11.35

Darwinian genetic drift Dmitri Parkhomchuk, A.C.McHardy Helmholtz Center for Infection Research, Braunschweig, Germany

11.10–11.35

The density of Wolbachia strain wMelPop in Drosophila melanogaster brain is inversely related to the level of hsp67bc gene expression Dina Malkeyeva^1, 2, E.V. Kiseleva^1 ^1ICG SB RAS, Novosibirsk, Russia ^2NSU, Novosibirsk, Russia

11:10–11:30

Application of genetic models for experimental study of cognitive functions and neuroprotection Maria Tikhonova^1, Amstislavskaya T.G.^1,2 ^1Scientific Research Institute of Physiology and Basic Medicine; ^2ICG SB RAS, Novosibirsk, Russia

11:10−13:00

Genotyping Precision Medicine Chairs: Michael Voevoda, Anatoliy Tulpakov

11:10–11:40

Inverse problems of population dynamics Alexander Kozhanov^1, Yu.A.Kosheleva^2 ^1Sobolev Institute of Mathematics SBRAS, Novosibirsk, Russia ^2Sakhalin State University, Yuzhno-Sakhalinsk, Russia

11:10−11:40

Monogenic forms of diabetes AnatoliyTulpakov Endocrine Research Center, Moscow, Russia

11.35–12.00

Sex chromosome evolution in Pamphagidae grasshoppers Ilyas Jetybayev^1,2, A.G. Bugrov ^2,3, O.G. Buleu ,^2,3, A.G. Bogomolov^1, N.B. Rubtsov^1,3 ^1ICG SB RAS, Novosibirsk, Russia ^2Institute of Systematics and Ecology of Animals, SB RAS, Novosibirsk, Russia ^3NSU, Novosibirsk, Russia

11.35-12.00

Targeted spatial genome modification in topologically associating domains structure in mouse embryonic stem cells Varvara Lukyanchikova, N.R. Battulin, O.L. Serov ICG SB RAS, Novosibirsk, Russia

11:30–11:50

DISC1 interactome and mental disorders: input of animal models Tatiana Lipina^1,2 ^1 Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia ^2 NSU, Novosibirsk, Russia

11:40−11:55

Genetic characteristics of different subtypes of maturity-onset diabetes of the young (MODY) in Novosibirsk Oksana Rymar, A.K. Ovsyannikova, E.V. Shakhtshneider, E.N. Voropaeva, M.I. Voevoda Institute of Internal and Preventive Medicine, Novosibirsk, Russia

11:40–11:55

Mathematical modeling of active substances and factors influence on functioning of plant root meristem Maria Savina^1, F.V. Kazantsev^1,2, V.V. Mironova^1,2 ^1Institute of Cytology and Genetics SBRAS, Novosibirsk, Russia; ^2NSU, Novosibirsk, Russia

12.00–12.25

Genetic diversity in native Siberian populations: correlation with climatic and geographical parameter Vladimir Kharkov^1,2, A.V. Markov^1,2, I.Yu. Khitrinskaya^1, V.A. Stepanov^1,2 ^1Research Institute for Medical Genetics, Tomsk, Russia; ^2Tomsk State University, Tomsk, Russia

12.00–12.25

The spatial map of avian genome Veniamin Fishman^1,2, N. Battulin^1,2, A. Maslova^3, O. Serov^1,2, A. Krasikova^3 ^1ICG SB RAS, Russia; ^2NSU, Novosibirsk, Russia; ^3Saint-Petersburg State University, St. Petersburg, Russia

11:55−12:10

Hereditary spastic paraplegias in Sudan: relative frequencies according to the mutated gene and identification of the second SPG57 mutation affecting TFG oligomerization Ahmed Khalid Mohamed Albashir Ahmed^1, I.N. Mohammed^1, A.A. Ahmed Hamed^1, M.A. Elseed^1, A. Johnson^4, M. Mairey^2,3, H.S.A.Mohamed^5,6, M.N. Idris^1,6, M.A.M. Salih^7, S.M. El-sadig^1,8, M.E. Koko^1, A.Y.O. Mohamed^9, Laure Raymond^2,3,15, M. Coutelier^2,3, F. Darios^3, R.A. Siddig^10, L.E.O Elsayed^1,2,3, A.M.A. Babai^1, H.M.O. Malik^1, Z.M.B. Mohammed^1, E.O.E. Mohamed^1, H.B. Eltahir^11, N.A. Magboul^12, E.E. Bushara^1, A. Elnour^13, S.M. Abdel Rahim^12, A. Alattaya^14, M.I. Elbashir^1, M.E. Ibrahim^15, A. Durr^3,16, A. Audhya^4, A. Brice^3,16, A.E. Ahmed^1,16, G. Stevanin^2,3,16

11:55–12:10