Biotop-report 2012

67

BioTOPics 44 | May 2012 

 Addresses 

BioTOP-Report 

Biotech Companies

OctreoPharm Sciences GmbH

OctreoPharm Sciences GmbH is a clinical development company focusing on diagnostic 

radiopharmaceuticals. 

octreopharmsciences.com

OpTricon Entwicklungsgesellschaft 

für optische Technologien mbH

OpTricon develops and produces mobile readers for quantitative analyzes of Immunoas-

says for Point-of-Care-diagnostics, especially Lateral Flow Assays (LFA). Additional busi-

ness segments are components and Systems for signal transmission and sensors for lbio-

analytics. opTricon develops the devices in partnership with the customers and works as 

OEM-suppliers and is certified by TÜV Rheinland according EN ISO 13485:2003+AC: 2007 

and EN ISO 9001:2008.

optricon.de

ORGANOBALANCE GmbH

ORGANOBALANCE is a company specializing in microbial strain development and screen-

ing. As a R&D contractor ORGANOBALANCE develops new biological products in the areas 

of nutrition, personal care and health care. The company draws on its own collection of mi-

crobial strains suitable for food applications and its OASSYS

®

 bioassay systems. In the field 

of “metabolic engineering” ORGANOBALANCE exploits Saccharomyces cerevisiae yeast for 

synthesis of substances for the industrial and pharmaceutical industry.

organobalance.com

ORGANOBALANCE Medical AG

ORGANOBALANCE Medical AG funds and promotes the research and development of nov-

el therapies based on specific probiotic cultures, aiming to develop active substances and 

mechanisms for innovative medicinal products and medical devices, as well as offer new 

therapeutic concepts for hitherto inadequately treatable indications.

organobalance 

medical.com

ovalehn GmbH

Production and application of specific recipes -containing IgY for diagnostics and oral, pas-

sive immune therapy.

ovalehn.de

Pentracor GmbH

In the case of cardiac infarction, C-reactive protein (CRP) results in an increase of the pri-

mary damage. Based on a new prototype, the company Pentracor GmbH aims to develop 

an adsorber for therapeutic reduction of CRP, lead it to approval, establish its certified 

production and market the product after clinical validation.

pentracor.com

Peptides&elephants GmbH

Custom synthesis of peptides and peptide libraries Development parallel Synthesis tech-

nologies Distributor of Peptide Synthesis Automation.

peptides.de

PharmaSol GmbH

Modification of ingredients or introduction of new metabolic pathways in plants with gene-

technology methods.

pharmasol-berlin.de

PlasmaChem GmbH

PlasmaChem GmbH is an innovative R&D and manufacturing company specializing in 

nanomaterials, plasma- and ultra-thin film technologies. The company manufactures nano-

coated medical implants (stents), nanomaterials, additives for metal plating (applied e.g. 

by Siemens AG), new additives to engine oils on the base of nanodiamonds and other 

industrial nanoproducts.

plasmachem.com

PolyAn, Gesellschaft zur 

Herstellung von Polymeren für 

spezielle Anwendungen und 

Analytik mbH

PolyAn is specialised in Molecular Surface Engineering (MSE). Using our surface modifica-

tion expertise PolyAn optimises the performance of analytical systems by improving the 

signal-to-noise ratio as well as the reproducibility of consumables for multiplex diagnostics, 

LifeScience research and screening applications. PolyAn?s product portfolio includes func-

tionalised microarray slides, microparticles for multiplex bead arrays and functionalised 

membranes for medical diagnostic applications.

poly-an.de

Preclinics Gesellschaft für 

präklinische Forschung mbH

Preclinics is a commercial cooperation partner for preclinical research and development. 

As a competent, creative and experienced partner preclinics investigates pharmaceutical 

substances, therapeutic methods and proceedings as well as medical products during the 

preclinical phase. Additional we provide custom antibody production in llama, goat, sheep, 

rabbit and other species.

preclinics.com

ProBioGen AG

ProBioGen is a Contract Development and Manufacturing Organization (CDMO) and Tech-

nology Provider, with extensive expertise in cell line engineering, process development 

(upstream- and downstream process) and GMP manufacturing of biopharmaceuticals. Of-

fering state-of-the-art contract development and manufacturing services as well as access 

to proprietary cell lines (AGE1.cell lines

®

) for the manufacturing of biopharmaceuticals and 

vaccines. The company possesses the manufacturing authorization from the competent 

authority and meets the quality standards required by the EMA and the FDA guidelines.

probiogen.de

ProteaImmun GmbH

ProteaImmun is a specialized proteomic company providing purified human proteins, an-

tibodies and ELISAs. Our proteins are designed for structural and functional studies of 

proteases screening and evaluation of protease inhibitors and modulators. Furthermore 

we develop highly sensitive ELISA kits and antibodies. Our Focus: MMPs, ADAMTs, HtrAs. 

ProteaImmun produces a unique range of recombinant proteases for medical and phar-

maceutical research. The main focus is on human Matrix Metalloproteases (MMPs), AD-

AMTS and HtrA proteins which play an important role in neurodegenerative disease, ancer 

and arthritis. Customer Service: ProteaImmun provides activity analysis by zymography 

adapted for MMPs.

proteaimmun.net

---

68

BioTOPics 44 | May 2012 

BioTOP-Report

 Addresses 

Biotech Companies

PROTEKUM - Umweltinstitut GmbH, 

Oranienburg

We plan to eliminated fluid und solid waste products in a manner which is compatible with 

environment protection. Our methodology is largely based on painstaking analysis. We 

use modern equipment and scientific methods. Protekum offers high-quality products and 

services in environmental analysis redevelopment.

protekum.de

Proteome Factory AG

Biomarker & target discovery, validation, analysis of food and ingredients, absolute quan-

tification of proteins and peptides, sequencing and characterization of proteins and an-

tibodies (CDR), 2DE and LC-MS based proteomics studies, pharmacokinetics, pharmaco, 

immuno and membrane proteomics, protein identification, characterization of proteins 

and peptides (PTMs, e.g. phosphorylation, glycosilation), quality control, mass determina-

tion, N-terminal amino acid sequencing, silver staining kit etc.

proteomefactory.com

Provitro GmbH

Provitro combines more than ten years of experiences in commercialisation of cell culture 

technologies, Tissue Microarrays and immunohistochemical analyses with the scientific 

expertise of the Pathological Institute of the Charité, Berlin. Based on a quality manage-

ment system according to ISO 9001:2008, we provide our customers not only with high-

quality products, CE marked in vitro-diagnostics and state-of-the-art services but also with 

individual solutions for their specific requests.

provitro.de

Rapidozym Gesellschaft für 

Laborhandel und DNA Diagnostika 

mbH

Expertise of cell biologists cell manufacturing and clean room technology specialists. Fo-

cuses on clinical stem cell product development portfolio are stroke, myocardial infarction 

and plastic surgery.

rapidozym.de

RENESA UG (haftungsbeschränkt)

Manufacturing and distribution of rapid tests, mainly for medical purposes (Point of Care 

Testing).

renesa.de

Revotar Biopharmaceuticals AG

Revotar develops innovative small molecule drugs (SMD) for the treatment of chronic in-

flammatory disorders such as, chronic obstructive pulmonary disease (COPD), Acute Lung 

Injury (ALI/ARDS) and ischemia / reperfusion. With its drug candidate bimosiamose, Revo-

tar has the worldwide most advanced pan-selectin-antagonist in clinical development in 

its product pipeline.

revotar.de

RiNA GmbH

RiNA has developed systems for cell-free protein biosynthesis based on pro- and eukary-

otic cell lysates. A synthesis service is realised in RiNA’s own laboratories and complements 

the EasyXpress Kits (Qiagen). The purchase of Roche´s RTS-products enables RiNA now to 

be a key player in the field of cellfree biosynthesis with a large variety of products. Another 

research focus is the development of aptamers (DNA and RNA) for biosensors.

rina-gmbh.eu

RIPAC-LABOR GmbH

RIPAC-LABOR offers high-quality diagnoses of bacterial infections, particularly in poultry, 

pigs and cattle, but also in other farm and domestic animals. The company uses pathogen 

differentiation to provide quick and effective methods for fighting pathogens. It performs 

resistance tests and epidemiological analyses and also focuses on producing herd-specific 

vaccines.

ripac-labor.de

RNAx GmbH

RNAx specializes in RNA-Interference services. It offers functional validations of si- and 

shRNAs, target validation studies using automated high throughput approaches, as well as 

whole genome screens with automated assays.

RNAx.de

RNL Europe GmbH

Manufacturing of stem cells from bone marrow and adipose tissue for therapeutic and 

plastic-aesthetical application. Manufacturing of adult stem cells for research (mesenchy-

mal stem cells, endothelial precursor cells). Banking of stem cells.

pharmicell.eu

Roboklon GmbH

Distribution, Marketing and Development of Products for Molecular Biological Research 

and Genetic Engineering.

roboklon.de

ROVALAB GmbH

Our Master Mixes for QPCR, Standard-, Hot Start- and High Fidelity PCR as well as our 

high quality critical raw materials and reagents such as DNA Polymerases and dNTPs are 

designed to help you successfully and rapidly solve your scientific and manufacturing tasks.

rovalab.com

Royal Biotech GmbH

Royal focuses on developing, manufacturing and marketing innovative kits, portable or 

micro-structured systems, and the next generation of diagnostic chips for near real-time 

environmental, food safety, disease and laboratory diagnostics.

royalbiotech.com

Scienion AG

Scienion is a life science company in the markets of dispensing systems and microarray 

technologies. The product portfolio comprises hardware, consumables and services. Sci-

enion’s leading product is the sciFLEXARRAYER dispensing system, available in a product 

line of six size versions. The dispenser allows the aspiration of ultra low liquid volumes 

from different reservoirs and non-contact micro drop delivery in the picoliter to microliter 

range onto a variety of carriers.

scienion.de

Sepiatec GmbH

Production, development and sales of automated HPLC machines for high-throughput pu-

rification and fractioning of complex substance compounds.

sepiatec.com

---

69

BioTOPics 44 | May 2012 

 Addresses 

BioTOP-Report 

Biotech Companies

Seramun Diagnostica GmbH

Seramun offers peptide synthesis, purification and conjugation of proteins, production 

of antibodies, customer research, in vitro-Diagnostics. We focus on the development and 

production of enzyme immunoassays for diagnosis of viral and bacterial infections and 

autoimmune diseases of the gastrointestinal tract, the development of multi-parameter 

assays as microtitre plate assays and as membrane immunoassays, as well as development 

of ready-to-use substrate solutions and for protein stabilizers.

seramun.com

SGS INSTITUT FRESENIUS Berlin 

GmbH & Co. KG

Analytical laboratory services and consulting for development, production and quality con-

trol of drugs.

institut-fresenius.de

SIFIN Institut für Immunpräparate 

und Nährmedien GmbH Berlin

Development, production and purification of monoclonal antibodies for use in diagnostics. 

Development and production of blood grouping reagents, Serafol

®

 bedside cards and test 

reagents for serotyping of Salmonellae, Shigellae, E. coli and Yersiniae. Development and 

production of culture media for microbiological diagnosis.

sifin.de

Signature Diagnostics AG

Signature Diagnostics is dedicated to the discovery, validation and commercial develop-

ment of novel diagnostic products that predict outcome and drug response in patients with 

colorectal cancer (CRC), non-small cell lung cancer (NSCLC) and ovarian cancer. Signature 

believes that patient selection and stratification based on molecular gene signatures will 

soon become an important component of routine cancer treatment.

signature- 

diagnostics.de

Silence Therapeutics AG

Silence Therapeutics AG is a leading RNAi therapeutics development company and offers a 

novel, proprietary siRNA technology (AtuRNAi) and proprietary systemic delivery systems 

for siRNA (AtuPLEX, DACC and DBTC). SILENCE pipeline consists of both partnered and 

internal programs of which 3 clinical phase II and 1 clinical phase I programs are partnered 

with Pfizer/Quark (2 ophthalmic indications) and Novartis/Quark (2 kidney indications). 

Silence?s internal lead compound Atu027 is currently in a Phase I clinical study for the 

treatment of solid tumours.

silence- 

therapeutics.com

SINA Science Services GmbH

SINA is a modern company providing elaborate services in molecular biology and protein 

biochemistry. Together with our industrial partners and customers from research institu-

tions we develop complex cloning and mutagenesis strategies including high-throughput 

applications. We offer cloning of genes, expression and purification of proteins, DNA and 

RNA isolation from numerous biological materials and the production of competent cells 

with high transformation efficiency.

sina-science-services.de

SLM- Speziallabor für angewandte 

Mikrobiologie GmbH

Microbiological quality control for medical devices, pharmaceuticals, cosmetics, drinking 

water, foodstuff, monitoring in clean rooms.

speziallabor.com

STRATEC Molecular GmbH 

STRATEC Molecular GmbH is a globally active provider of innovative system solutions for 

nucleic acid sample collection, stabilization, and both manual and automated purifica-

tion from any sample type. Since 1992 the company is internationally respected for its 

outstanding and high performance technology platforms and offers a broad spectrum of 

superior products for molecular diagnostics, drug discovery and Life Science research.

invitek.de

Strix Diagnostics GmbH

Strix Diagnostics is a medical diagnostics company specializing in customized develop-

ment of certified analytical systems for multiparameter in vitro-diagnostics.

strix-diagnostics.de

Surflay Nanotec GmbH

Surflay Nanotec GmbH, a spin-off company from Capsulution NanoScience AG, is special-

ized on coating colloidal and planar materials with functional films. Key technology is the 

patented LbL-Technology

®

 with polymers. Applications are in the fields of separation mate-

rials, pigment encapsulation, bio-sensing and diagnostic particles. In addition to customer 

tailored projects Surflay offers an unique range of products of tunable multifunctional 

nano-or microparticles and dye-labeled polymers.

surflay.com

Thanares GmbH

Development, use and marketing of analytical process for diagnostic and therapeutic pur-

poses. Future business activities: detection process for bioactive substances in bodily flu-

ids, isolation, characterization and investigation of bioactive compounds from plants, in 

particular insoluble proteins or low concentrations of proteins, development of low cost 

genetic systems for over-expression and/or production of such proteins.

thanares.com

TheraKine BioDelivery GmbH

Development of antibody drug delivery systems and related tasks.

therakine.com

Thermo Fisher Scientific - 

B·R·A·H·M·S GmbH

Thermo Scientific Biomarkers (B·R·A·H·M·S GmbH) explores, develops and produces new 

diagnostic test procedures to improve the diagnosis, and thereby the treatment, of life-

threatening illnesses. This takes place with over 470 employees, in the disease areas in-

fectiology, cardiology and pneumology as well as thyroid, autoimmunity and cardiology on 

the basis of our own patented biomarkers. Since October 2009 B·R·A·H·M·S GmbH is part 

of Thermo Fisher Scientific Inc. (NYSE: TMO), the world leader in serving science.

thermoscientific.com/

brahms

TIB MOLBIOL Syntheselabor GmbH

In 1990, TIB MOLBIOL became the first German manufacturer of oligonucleotides. In ad-

dition to designing and synthesizing primers and probes for Real-Time PCR assays, we 

develop and produce LightMix

®

 Kits for Roche Diagnostics LightCycler

®

 Instruments, cov-

ering applications in Clinical Chemistry, Pharmacogenetics, Pathogen Detection, as well as 

Cancer Research. TIB MOLBIOL is ISO 13485 and ISO 9001 certified.

tib-molbiol.com

---

70

BioTOPics 44 | May 2012 

BioTOP-Report

 Addresses 

Biotech Companies

TransTissue Technologies GmbH

TransTissue has been a subsidiary of BioTissue Technologies, Freiburg since September 

2001. With more than 15 years of experience in regenerative medicine, the scientists of 

TransTissue Technologies have developed second-generation autologous tissue replace-

ments, e.g. cartilage and bone grafts. We are mainly concerned with inventions and the 

development of tissue engineering products for regenerative medicine. We offer a broad 

panel of services in the field of regenerative medicine.

transtissue.com

UGA Biopharma GmbH

UGA Biopharma a private Research and Development company, focuses on Research, De-

velopment and Commercialization of Biopharmaceutical products under contract with 

other Biopharmaceutical companies. UGA Biopharma conducts power of biosciences to 

develop high-tech, last generation of biomedicine, diagnostic kits, molecular biology items 

and also offers world class services in biotechnology area.

ugabiopharma.com/ 

de/index.html

Umwelttechnik Dr. Bartetzko GmbH Feasibility studies, development, planning, construction and operation of biotechnological 

plants for groundwater, process water and waste water purification. Accredited microbio-

logical laboratory for the investigation of drinking water, groundwater, bath water, soils, 

food, anti-microbial active ingredients and sterility according to Ph.Eur, approved in ac-

cordance with BiostoffV and the German infection protection act (Infektionsschutzgesetz).

bartetzko.com

VasoTissue Technologies GmbH

The company is active in the field of product development for advanced medical therapies. 

For its first product - the endothelialised vascular graft (“VasoGraft”)- VasoTissue obtained 

a manufacturing license in 2008. Currently, VasoTissue´s focus is on conducting its first 

clinical trial.

vasotissue.de

Zellwerk GmbH

Zellwerk produces the proprietary Z

®

 RP cell cultivation system, comprising rotating bed 

bioreactor, GMP Breeder, Control Unit, software. Bioreactors with 50-5000 ml volume, 

0,2-2 m² seeding surface, different cell carriers, can be delivered. In this culturing system 

cells grow tissue-like, being embedded in self-generated extra-cellular matrix. The tech-

nology opens unique opportunities for the GMP-compliant expansion of stem cells and 

primary cells, manufacturing of cell-seeded implants as well as production of recombinant 

proteins. In addition, we have recently developed a new bioreactor for expansion of im-

mune cells for cell therapy of leukemia and several types of cancer. 

zellwerk.biz

Zentrum für molekulare Onkologie 

GmbH

Innovative methods for diagnostic and therapy of tumor diseases - Molecular genetics (K-

RAS, PCA3, Septin9, ...) - Chemoresistance assay for prediction of chemotherapy - Pathol-

ogy Development of new biomarkers and analytical services for studies.

molekulare- 

onkologie.eu

Zytomed Systems GmbH

Zytomed Systems´ focus is the development, production and distribution of antibodies 

and detection systems for immunohistochemical cancer diagnostics as well as reagents 

and kits for in-situ hybridisation.

zytomed-systems.de

---

Life Sciences.

Living Research. 

Berlin. Brandenburg.

A vibrant network

Berlin-Brandenburg is one of Europe’s leading locations for the 

Life Sciences. It is also an R&D capital that magnetically attracts 

the world’s top scientists. Here you’ll find attractive subsidy condi-

tions, close linkages between business and science, the highest 

concentration of R&D in Europe, a dynamic startup scene and a 

multifaceted entrepreneurial  environment made up of roughly 480 

pharmaceutical, biotech and medical engineering companies. 

Come discover this one-of-a-kind landscape for scientists and 

entrepreneurs.

www.biotop.de/business

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BioTOP is a joint initiative of the state of Berlin and the state of Brandenburg under the umbrella of the TSB Innovationsagentur Berlin GmbH and takes part in the Cluster 

Management Health Capital. BioTOP is funded by the federal state of Berlin, the federal state of Brandenburg and the Investitionsbank Berlin, co-funded by the European Union 

(European Fund for Regional Development). Investing in your Future