Biotop-report 2012



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BioTOPics 44 | May 2012 

 Industry 

BioTOP-Report 

work in companies with 11-50 employees. More than 52 % of 

all employees in the region’s biotech industry work for the 19 

companies that have more than 50 employees. The thematic fo-

cus also remained unchanged in recent years. The main remains 

biomedicine, and here diagnostics. 

Deals and product developments

The year 2011 saw a range of new cooperation agreements and 

important milestones in product development. Here are a few 

selected examples from the wide spectrum of activities: 

ProBioGen AG, a specialist in developing production cell lines, 

process engineering and the GMP production of biopharmaceuti-

cal active agents, has been very active. The company closed sev-

eral license agreements to use their cell lines, including a non-

exclusive license agreement with Boehringer Ingelheim to use 

ProBioGen’s innovative glyco-engineering technology "GlymaxX" 

Boehringer Ingelheim will use the technology in biopharmaceuti-

cal contract development and production. 



ORGANOBALANCE GmbH signed a worldwide exclusive license 

agreement with Lonza under which the licensee develops, pro-

duces and markets a probiotic lactobacillus strain. The probiotic 

strain developed by ORGANOBALANCE acts against Helicobacter 

pylori (H. pylori). The license provides Lonza with the basis for ac-

cess to the probiotic market. 

Group, Germany’s largest private hospital group 

++++ 


The first evaluation 

data from the clinical study of MGN1601 by MOLOGEN AG in kidney cancer 

therapy are far more encouraging than expected

SEPTEMBER 2011

The colorectal cancer test Epi proColon

®

 2.0 developed by Epigenomics 



detects 95 % of cancer cases in a clinical trial 

++++ 


Glycotope enrols first 

patients in phase I trial with TrasGEX (TM), a glycooptimized HER2 biobetter 

antibody 

++++ 


ATLAS Biolabs joins the bioinformatics project NGSgoesHPC 

of the German Federal Ministry of Education and Research (BMBF)



OCTOBER 2011

Humedics successfully closes its first VC funding contract with Charité Bio-

medical Fund, VC-Fonds Technologie, KfW, the German high-tech start-up 

fund HTGF und Ventegis Capital AG 

++++ 

Epigenomics announces market 



launch of Epi proColon

®

 2.0 CE in Europe 



++++ 

ProBioGen and Inhibrx sign 

licence deal on GlymaxX

®

 ADCC technology for therapeutic antibody develop-



ment

NOVEMBER 2011

MOLOGEN AG achieves the targets of its kidney cancer study with MGN1601 

ahead of schedule 

++++ 


co.don AG receives the entrepreneur award of the 

Eastern German Savings Bank Federation (OSV), one of the most prestigious 

distinctions awarded in Germany’s eastern federal states

DECEMBER 2011

SCIENION founds the US subsidiary SCIENION US, Inc. 

++++ 

The new method 



developed by the company Caprotec called Capture Compound Mass Spec-

trometry is used to research new anti-cancer agents in cooperation with the 

Leibniz-Institute for Molecular Pharmacology (FMP) 

++++ 


NOXXON com-

pletes Phase I trial for the SDF-1 inhibitor NOX-A12



JANUARY 2012 

ORGANOBALANCE signs licence agreement with Sanofi Pasteur for access 

to a modified yeast strain for vaccine applications 

++++ 


EPO starts strategic 

cooperation with vivoPharm to enhance its market position in the US.



FEBRUARY 2012

The Epi proLung

®

 BL assay by Epigenomics demonstrates good performance 



as a confirmation test for patients with suspected lung cancer 

++++ 


Con-

struction starts on Europe’s largest hospital laboratory in Berlin-Wedding: 

Groundbreaking ceremony for the operations facility of Labor Berlin – Charité 

Vivantes GmbH



MARCH 2012

ProBioGen's licenses its AGE1.CR

®

 cell line for viral vaccine production to 



Ceva 

++++ 


SCIENION introduces sciREADER CL for colorimetric detection of 

multiplex assays




6

BioTOPics 44 | May 2012 

BioTOP-Report

 Industry 



EPO Berlin-Buch GmbH has closed a cooperation agreement 

with  vivoPharm, an Australian/American company. vivoPharm 

also focuses on preclinical pharmacological research and will 

make the primary tumour models developed by EPO more in-

tensively available to cancer research facilities in the USA. For 

the first time, EPO technologies are therefore giving biotechnol-

ogy and pharmaceutics companies in the USA the opportunity to 

test the cancer medicines they are developing in models that are 

close to clinical practice and to seek and validate predictive (bio-) 

markers for their efficacy. 

In the field of regenerative medicine, co.don AG has signed a 

framework agreement with Germany’s largest association of clin-

ics, the Asklepios Group. It enables Asklepios Clinics throughout 

Germany to treat patients with the cell-based biological medicine 

ARTROCELL 3D

®

/co.don chondrosphere



®

. The product is used for 

regenerative treatment of cartilage damage, e.g. of the knee, and 

is an ideal extension of the therapies offered by the Asklepios 

Hospitals. 

KNAUER GmbH announced a license and cooperation agreement 

with ChromaCon AG, under which ChromaCon grants KNAUER 

a semi-exclusive license for world-wide marketing, distribution 

and after-sales services of the Contichrom™ lab-scale preparative 

chromatography unit for use in discovery, process development 

and small scale production. In an internationalisation measure, 



Scienion AG founded an American subsidiary in Princeton to de-

velop a base in this important key market and meet the growing 



Number of Employees According to Company Size

In comparison to the previous year, the average number of employees per company increased by 4,5 % in the 1-10 category and decreased by 5 % in the 11-50 category. 

The average number of employees in the category > 50 employees increased by 10%. (Source: Own survey, BioTOP database, 215 companies questioned, February 2012)

 2.200


 2.100

 2.000


 1.900

 1.800


 1.700

 1.600


 1.500

 1.400


 1.300

 1.200


 1.100

 1.000


 900

 800


 700

 600


 500

 400


 300

 200


 100

 0 


Number of employees

02 03 04  05  06  07 08 09 10



11

2117

19 companies > 51 employees

02 03 04  05  06  07 08 09 10

11

134 companies 1-10 employees



645

02 03 04  05  06  07 08 09 10



11

62 companies 11-50 employees



1306


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