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BioTOPics 44 | May 2012
Industry
BioTOP-Report
work in companies with 11-50 employees. More than 52 % of
all employees in the region’s biotech industry work for the 19
companies that have more than 50 employees. The thematic fo-
cus also remained unchanged in recent years. The main remains
biomedicine, and here diagnostics.
Deals and product developments
The year 2011 saw a range of new cooperation agreements and
important milestones in product development. Here are a few
selected examples from the wide spectrum of activities:
ProBioGen AG, a specialist in developing production cell lines,
process engineering and the GMP production of biopharmaceuti-
cal active agents, has been very active. The company closed sev-
eral license agreements to use their cell lines, including a non-
exclusive license agreement with Boehringer Ingelheim to use
ProBioGen’s innovative glyco-engineering technology "GlymaxX"
Boehringer Ingelheim will use the technology in biopharmaceuti-
cal contract development and production.
ORGANOBALANCE GmbH signed a worldwide exclusive license
agreement with Lonza under which the licensee develops, pro-
duces and markets a probiotic lactobacillus strain. The probiotic
strain developed by ORGANOBALANCE acts against Helicobacter
pylori (H. pylori). The license provides Lonza with the basis for ac-
cess to the probiotic market.
Group, Germany’s largest private hospital group
++++
The
first evaluation
data from the clinical study of MGN1601 by MOLOGEN AG in kidney cancer
therapy are far more encouraging than expected
SEPTEMBER 2011
The colorectal cancer test Epi proColon
®
2.0 developed by Epigenomics
detects 95 % of cancer cases in a clinical trial
++++
Glycotope enrols first
patients in phase I trial with TrasGEX (TM), a glycooptimized HER2 biobetter
antibody
++++
ATLAS Biolabs joins the bioinformatics project NGSgoesHPC
of the German Federal Ministry of Education and Research (BMBF)
OCTOBER 2011
Humedics successfully closes its first VC funding contract with Charité Bio-
medical Fund, VC-Fonds Technologie, KfW, the German high-tech start-up
fund HTGF und Ventegis Capital AG
++++
Epigenomics announces market
launch of Epi proColon
®
2.0 CE in Europe
++++
ProBioGen and Inhibrx sign
licence deal on GlymaxX
®
ADCC technology for therapeutic antibody develop-
ment
NOVEMBER 2011
MOLOGEN AG achieves the targets of its kidney cancer study with MGN1601
ahead of schedule
++++
co.don AG receives the entrepreneur award of the
Eastern German Savings Bank Federation (OSV), one of the most prestigious
distinctions awarded in Germany’s eastern federal states
DECEMBER 2011
SCIENION founds the US subsidiary SCIENION US, Inc.
++++
The new method
developed by the company Caprotec called Capture Compound Mass Spec-
trometry is used to research new anti-cancer agents in cooperation with the
Leibniz-Institute for Molecular Pharmacology (FMP)
++++
NOXXON com-
pletes Phase I trial for the SDF-1 inhibitor NOX-A12
JANUARY 2012
ORGANOBALANCE signs licence agreement with Sanofi Pasteur for access
to a modified yeast strain for vaccine applications
++++
EPO starts strategic
cooperation with vivoPharm to enhance its market position in the US.
FEBRUARY 2012
The Epi proLung
®
BL assay by Epigenomics demonstrates good performance
as a confirmation test for patients
with suspected lung cancer
++++
Con-
struction starts on Europe’s largest hospital laboratory in Berlin-Wedding:
Groundbreaking ceremony for the operations facility of Labor Berlin – Charité
Vivantes GmbH
MARCH 2012
ProBioGen's licenses its AGE1.CR
®
cell line for viral vaccine production to
Ceva
++++
SCIENION introduces sciREADER CL for colorimetric detection of
multiplex assays
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BioTOPics 44 | May 2012
BioTOP-Report
Industry
EPO Berlin-Buch GmbH has closed a cooperation agreement
with vivoPharm, an Australian/American company. vivoPharm
also focuses on preclinical pharmacological research and will
make the primary tumour models developed by EPO more in-
tensively available to cancer research facilities in the USA. For
the first time, EPO technologies are therefore giving biotechnol-
ogy and pharmaceutics companies in the USA the opportunity to
test the cancer medicines they are developing in models that are
close to clinical practice and to seek and validate predictive (bio-)
markers for their efficacy.
In the field of regenerative medicine, co.don AG has signed a
framework agreement with Germany’s largest association of clin-
ics, the Asklepios Group. It enables Asklepios Clinics throughout
Germany to treat patients with the cell-based biological medicine
ARTROCELL 3D
®
/co.don chondrosphere
®
. The product is used for
regenerative treatment of cartilage damage, e.g. of the knee, and
is an ideal extension of the therapies offered by the Asklepios
Hospitals.
KNAUER GmbH announced a license and cooperation agreement
with ChromaCon AG, under which ChromaCon grants KNAUER
a semi-exclusive license for world-wide marketing, distribution
and after-sales services of the Contichrom™ lab-scale preparative
chromatography unit for use in discovery, process development
and small scale production. In an internationalisation measure,
Scienion AG founded an American subsidiary
in Princeton to de-
velop a base in this important key market and meet the growing
Number of Employees According to Company Size
In comparison to the previous year, the average number of employees per company increased by 4,5 % in the 1-10 category and decreased by 5 % in the 11-50 category.
The average number of employees in the category > 50 employees increased by 10%. (Source: Own survey, BioTOP database, 215 companies questioned, February 2012)
2.200
2.100
2.000
1.900
1.800
1.700
1.600
1.500
1.400
1.300
1.200
1.100
1.000
900
800
700
600
500
400
300
200
100
0
Number of employees
02 03 04 05 06 07 08 09 10
11
2117
19 companies > 51 employees
02 03 04 05 06 07 08 09 10
11
134 companies 1-10 employees
645
02 03 04 05 06 07 08 09 10
11
62 companies 11-50 employees
1306