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6. SONUÇ ve ÖNERİLER Yapılan incelemelerde sağlıklı koyunlarda NSAİİ’lerden fluniksin meglumin ve meloksikam uygulamasının hemostatik değişiklikler (PLT, PT, APTT ve FIB) üzerine etkinliğinin değerlendirildiği bir çalışmaya rastlanılmamış olması bu araştırmanın orjinalliği ile birlikte önemini de göstermektedir. İnsan domuz, rat, koyun ve köpek koagulasyon ölçümleri üzerine yapılan çalışmalarda, koyun ve insan koagulasyon testleri arasında benzerlik olduğu rapor edilmiştir. Ayrıca, yapılan son çalışmalar koagülasyon bozuklukları için bir model olarak koyun kullanımını destekler niteliktedir. Bu çalışmada sağlıklı koyunlarda uygulanan fluniksin meglumin ve meloksikamın hemostatik değişiklikler üzerine etkinliğinin belirlenmesi ile literatürdeki önemli bir boşluğun doldurulması sayesinde gerek veteriner hekimlik alanında gerekse insan hekimliğinde tedavi takibi üzerine yapılacak çalışmalara yön verilmesini sağlayacaktır. Sağlıklı koyunlara uygulanan fluniksin meglumin ve meloksikamın hemostatik değişikliklerden trombosit sayılarının, PT seviyelerinin ve fibrinojen konsantrasyonlarının zamana bağlı olarak değişikliğe uğradığı gözlemlendi. Bu bağlamda sonuç olarak NSAİİ’ lerden fluniksin meglumin ve meloksikam ile tedavi edilen koyunlarda konvansiyonel rutin hemostatik değişikliklerden PLT, PT, FIB düzeylerinin dikkatle takibi önerilmektedir. KAYNAKLAR Abacıoğlu N. Aljezi, yangı, pirezis ve nonsteroidal analjezik antiinflamatuvar ilaçlar. Bökesoy, A. Çakıç, İ. Melli, M. eds. In: Farmakoloji Ders Kitabı. Ankara: Türk Farmakoloji Derneği, 2000; pp. 473-95. Anonim 1. Stokol T (ed). College of Veterinary Medicine. Hemostasis. Introduction, Tests of hemostasis, Disorders of hemostasis, Transfusion medicine. http://ahdc.vet.cornell.edu/clinpath/modules/coags/coag.htm. Erişim Tarihi: 27.05.2015. Anonim 2. Susan G. 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ÖZGEÇMİŞ Soyadı, Adı : TURGUT Sedat Uyruk : T.C Doğum yeri ve tarihi : Doğubayazıt/07.07.1988 Telefon : 553-6212062 E-mail : sedat.turgut@adu.edu.tr Yabancı Dil : İngilizce EĞİTİM
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AKADEMİK YAYINLAR 1. MAKALELER xxx 2. PROJELER xxx 3. BİLDİRİLER A) Uluslarası Kongrelerde Yapılan Bildiriler xxx B) Ulusal Kongrelerde Yapılan Bildiriler xxx Yüklə 352,11 Kb. Dostları ilə paylaş:
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