Personal Research Database

Title: Journal of Hepatology

Full Journal Title: Journal of Hepatology

ISO Abbreviated Title: J. Hepatol.

JCR Abbreviated Title: J Hepatol

ISSN: 0168-8278

Issues/Year: 12

Journal Country/Territory: Netherlands

Language: English

Publisher: Elsevier Science BV

Publisher Address: Po Box 211, 1000 AE Amsterdam, Netherlands

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Gastroenterology & Hepatology: Impact Factor 4.750, / (2001)

Kjærgård, L.L., Sørensen, T.I.A. and Gluud, C. (2000), Is the journal impact factor a predictor of quality: A review of randomised clinical trials in 11 journals. Journal of Hepatology, 32 (S2), 137.

Full Text: J\J Hep32, 137.pdf

? Lamers, M.M.H., van Oijen, M.G.H., Pronk, M. and Drenth, J.P.H. (2010), Treatment options for autoimmune hepatitis: A systematic review of randomized controlled trials. Journal of Hepatology, 53 (1), 191-198.

Full Text: 2010\J Hep53, 191.pdf

Abstract: Background & Aims: Predniso(lo)ne with or without azathioprine is considered the mainstay in the treatment of autoimmune hepatitis (AIH), but many therapeutic options are available. The primary objective of this review was to explore the published literature on the optimal induction and subsequent maintenance therapy for AIH. Methods: We performed a systematic search on electronic databases MEDLINE (1950-07.2009), Web of Science, Cochrane, and the website www.clinicaltrials.gov. Randomized controlled trials (RCTs) on apparent beneficial treatment regimens as induction or maintenance treatment in AIH were included. Pediatric studies were excluded. We calculated relative risks (RR) for comparison of treatment options on the primary outcome measure, which was defined as clinical, biochemical and histological remission. Results: Eleven RCTs were included, of which 7 studies evaluated the induction therapy in AIH patients: 3 treatment naive (n = 253), 2 relapse (n = 53), 2 combination of naive and relapse (n = 110). The remaining 4 studies (n = 162) assessed maintenance therapy. All but one maintenance study (thymostimulin versus no therapy) studied predniso(lo)ne (PRED), azathioprine (AZA) or combination PRED + AZA. We found no differences in primary outcome between induction therapy with PRED and PRED + AZA in treatment naive patients (RR = 0.98; 95% CI 0.65-1.47). AZA monotherapy as induction was considered as not viable because of a high mortality rate (30%). This was similar in AIH patients who relapsed: RR for PRED versus PRED + AZA for inducing remission was not different: 0.71 (95% CI 0.37-1.39). PRED + AZA maintained remission more often than PRED (RR = 1.40; 95% CI 1.13-1.73). Also AZA maintained a higher remission rate than PRED (RR = 1.35; 95% CI 1.07-1.70). Maintenance of remission was not different between PRED + AZA and AZA (RR = 1.06; 95% CI 0.941.20). Conclusions: Based on available RCTs, PRED monotherapy and PRED + AZA combination therapy are both viable induction therapies for AIH treatment naives and relapsers, while for maintenance therapy PRED + AZA and AZA therapy are superior to PRED monotherapy. (C) 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

Keywords: Autoimmune, Azathioprine, Challenges, Chronic Active Hepatitis, Cochrane, Combination, Combination Therapy, Databases, Hepatitis, Literature, Liver-Disease, Maintenance, Medline, Methods, Monotherapy, Mortality, Outcome, Prednisone, Primary, Randomized Controlled Trials, Remission, Review, Science, Systematic, Systematic Review, Therapy, Treatment, Web of Science, Withdrawal

Title: Journal of Heterocyclic Chemistry

Full Journal Title: Journal of Heterocyclic Chemistry

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? Rao, K.V. (1997), Semi-synthesis of paclitaxel from naturally occurring glycosidic precursors. Journal of Heterocyclic Chemistry, 34 (2), 675-680.

Abstract: Paclitaxel, an antirumor drug effective on ovarian and breast carcinomas, is currently being produced both by direct isolation from the bark of Taxus brevifolia and by semi-synthesis from a natural precursor, 10-deacetyl baccatin III. Although other potential precursors such as 10-deacetyl paclitaxel-7-xyloside were known since 1984, their conversion to paclitaxel could not be achieved because of the lack of suitable methodology for hydrolyzing the xylose residue, compatible with the stability of the compound. A method is described here using periodate, followed by phenylhydrazine, to effect deglycosidation of 10-deacetyl paclitaxel-7-xyloside to form 10-deacetyl paclitaxel. In addition, by including an intermediate acetylation step before the reaction with phenylhydrazine, ‘‘direct’’ conversion of this xyloside to paclitaxel itself, is described. Because 10-deacetyl paclitaxel-7-xyloside occurs at >0.1% in the bark of Taxus brevifolia, its successful hydrolytic conversion to paclitaxel represents an extremely important reaction for the enhanced availability of this drug.

Keywords: Taxus-Brevifolia, Taxol, Taxanes, Efficient, Agent, Bark

Title: Journal of High Resolution Chromatography: HRC

(HRC, J. High Resolut. Chromatogr.)

? Onuska, F.I. and Terry, K.A. (1991), Supercritical fluid extraction of polychlorinated dibenzo-para-dioxins from municipal incinerator fly-ash. Journal of High Resolution Chromatography: HRC, 14 (12), 829-834.

Title: Journal of High Resolution Chromatography & Chromatography Communications

Full Journal Title: Journal of High Resolution Chromatography & Chromatography Communications

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? Jaroniec, M and Suprynowiczsienko, D. (1983), Dependence of selectivity and resolution upon composition of the binary mobile phase in LSC. Journal of High Resolution Chromatography & Chromatography Communications, 6 (1), 27-30.

? Borowko, M. and Jaroniec, M. (1984), Multilayer effects in liquid adsorption chromatography with mixed mobile phases. Journal of High Resolution Chromatography & Chromatography Communications, 7 (4), 203-207.