Thomas mavromoustakos

128.X. Tzoupis, G. Leonis, S. Durdagi, V. D. Mouchlis, T. Mavromoustakos, M. G. Papadopoulos. Design of a series of novel HIV-1 PR fullerene-based inhibitors J. Comp. Aided Mol. Des . 25, 959-976 (2011).

129.A. Politi, G. Leonis, H. Tzoupis, D. Ntountaniotis, H. Reis, M. G. Papadopoulos, S. G. Grdadolnik, T. Mavromoustakos. Conformational Properties and Energetic Analysis of Aliskiren in Solution and Receptor Site. Chem. Informatics 30, 973-985 (2011).
130.S. Durdagi, M. Papadopoulos, T. Mavromoustakos. An effort to discover the preferred conformation of the potent AMG3 cannabinoid analog when reaching the active sites of the cannabinoid receptors. Eur. J. Med. Chem. 47(1) 44-51 (2012).
131.G.K. Batsala, V. Dokorou , N. Kourkoumelis, M.J. Manos, A.J. Tasiopoulos, T. Mavromoustakos, M. Simcic, S. Golic Grdadolnik, S.K. Hadjikakou Copper(I)/(II) or silver(I) ions towards 2-mercaptopyrimidine: An exploration of a chemical variability with possible biological implication. Inorg. Chim. Acta 382 146-157 (2012).
132.V. Mouchlis, V. Michopoulou, V.C.-Kokotou, T. Mavromoustakos, E.A. Dennis, G. Kokotos Binding Conformation of 2-Oxoamide Inhibitors to Group IVACytosolic Phospholipase A2 Determined by Molecular Docking Combined with Molecular Dynamics. Ch. Inf. Mod. 52(1) 243-254 (2012).

133.A. Hodzic, P. Zoumpoulakis, G. Pabst., T. Mavromoustakos, M. Rappolt. Losartan’s affinity to fluid bilayers couples to lipid/cholesterol interactions. Phys. Chem. Chem. Phys. 14, 4780-4788 (2012).

134.V. Mouchlis, G. Melagraki, T. Mavromoustakos, G. Kollias, A. Afantitis. Molecular modeling on pyrimidine-urea inhibitors of TNF-α production: an integrated approach using a combination of molecular docking, classification techniques and 3D-QSAR CoMSIA J. Ch. Inf. Mod. 52, 711-723 (2012).
135.H. Tzoupis, G. Leonis, G. Megariotis, C.T. Supuran, T. Mavromoustakos, M.G. Papadopoulos. Dual Inhibitors for Aspartic Proteases HIV-1 PR and Renin: Advancements in AIDS-Hypertension-Diabetes Linkage via Molecular Dynamics, Inhibition Assays, and Binding Free Energy Calculations. J. Med. Chem. 55, 5784-5796 (2012).
136.C. Fotakis, G. Megariotis, D. Christodouleas, E. Kritsi, M. Zervou, P. Zoumpoulakis, D. Ntountaniotis, C. Potamitis, A. Hodzic, G. Pabst, M. Rappolt, G. Mali, J. Baldus, C. Glaubitz, M. G. Papadopoulos, A. Afantitis, G. Melagraki, T. Mavromoustakos. Comparative study of the AT1 receptor prodrug antagonist candesartan cilexetil with other sartans on the interactions with membrane bilayers. Biochim. Biophys. Acta 1818, 3107-3120 (2012).

137.N. Varvarigou, G. Megariotis, G. Leonis, E. Vrontaki, A.-M. Maniati, M.Vlachou, A. E.R. Kompogennitaki, M. G. Papadopoulos, S. G. Grdadolnik, D. Komiotis, Thomas Mavromoustakos, Andrew Tsotinis. Conformational analysis of two novel cytotoxic C2-substituted pyrrolo[2,3-f]quinolines in aqueous media, organic solvents, membrane bilayers and at the putative active site Bioorganic & Medicinal Chemistry 20, 6276-6284 (2012).

138.E. Vrontaki, G. Leonis, M. G. Papadopoulos, M. Simcic, S. Golic Grdadolnik, A. Afantitis, G. Melagraki, S. K. Hadjikakou, and T. Mavromoustakos. Comparative Binding Effects of Aspirin and Anti-Inflammatory Cu Complex in the Active Site of LOX-1 52(12) J. Chem. Inf. Mod. 3293-3301 (2012).
139.G. Agelis, A. Resvani, S. Durdagi, K. Spyridaki , T.Tumová,J. Slaninová, P. Giannopoulos, D. Vlahakos, G. Liapakis,T.Mavromoustakos, J. Matsoukas.The discovery of new potent non-peptide Angiotensin II AT1 receptor blockers:A concise synthesis, molecular docking studies and biological evaluation of N-substituted 5-butylimidazole derivatives. Eur. J. Med. Chem. 55 358-374 (2012).
140.P.M. Minakakis, E. Papavassilopoulou, T. Mavromoustakos. Synthesis of new optically active 2-pyrrolidinones. Molecules 18, 50-73 (2013).
141.E. Kritsi, C. Potamitis, S. Durdagi, P. Zoumpoulakis, S.G. Grdadolnik, T. Mavromoustakos. Molecular insights into the AT₁ antagonism based on biophysical and in silico studies of telmisartan. Med. Chem. Res. DOI 10.1007/s00044-012-046405 (2013).
142.G. Agelis, A. Resvani, C. Koukoulitsa, T. Tumonva, J. Slaninova, D. Kalavrizioti, K. Spyridaki, A. Afantitis, G. Melagraki, A. Siafaka, E. Gkini, G. Megariotis, S.G. Grdadolnik, M. Papadopoulos, D. Vlahakos, M. Maragoudakis, G. Liapakis, T. Mavromoustakos, J. Matsoukas. Rational design, efficient syntheses and biological evaluation of N,N’-symmetrically bis-substituted butylimidazole analogs as a new class of potent Angiotensin II receptor blockers. Eur. J. Med. Chem. 62, 352-370 (2013).
143.H.Tzoupis, G. Leonis, T. Mavromoustakos, M. G. Papadopoulos. A Comparative Molecular Dynamics, MM−PBSA and Thermodynamic Integration Study of Saquinavir Complexes with Wild-Type HIV-1 PR and L10I, G48V, L63P, A71V, G73S, V82A and I84V Single Mutants. J. Chem. Theory Comput. 9, 1754-1764 (2013).
144.T. Mavromoustakos, G. Aggelis, A. Resvani, D. Ntountaniotis, P. Chatzigeorgiou, C. Koukoulitsa, J. Matsoukas, T. Čendak, U. Codec, G. Mali. Interactions of the potent synthetic AT1 antagonist analog BV6 with membrane bilayers and mesoporous silicate matrices. Biochim. Biophys. Acta 1828, 1846-1855 (2013).

145.G. Agelis, K. Kelaidonis, A. Resvani, D. Kalavrizioti, M.E. Androutsou, P. Plotas, D. Vlahakos, C. Koukoulitsa, T. Mavromoustakos, J. Matsoukas. Facile and efficient syntheses of a series of N-benzyl and N-biphenylmethyl substituted imidazole derivatives based on (E)-urocanic acid, as Angiotensin II AT1 receptor blockers. Molecules 18, 7510-7532 (2013).

146. M. Zervou, Z. Cournia, C. Potamitis, G. Patargias, S. Durdagi, S.G. Grdadolnik, T. Mavromoustakos. Insights into the molecular basis of action of the AT1 antagonist losartan using a combined NMR spectroscopy and computational approach. In press. Biochim. Biophys. Acta, 1838(3), 1031-1046 (2014).

147. P. Ioannis, T. Mavromoustakos. Monounsaturated fatty acid ether oligomers formed during heating of virgin olive oil shows agglutination activity against human red blood cells. Journal of Agricultural and Food Chemistry, 62, 867-874 (2014).
148. D. Ntountaniotis, T. Kellici, A. Tzakos, P. Kolokotroni, T. Tselios, J. Becker-Baldus, C. Glaubitz, Sonyan-Lin, A. Makriyannis, T. Mavromoustakos. The application of solid state NMR spectroscopy to study Candesartan Cilexetil (TCV-116) membrane interactions. Comparative study with the AT1 antagonist drug olmesartan Biochim. Biophys. Acta 1838, 2439-2450 (2014).
149. K. Spyridakis, M.T. Matsoukas, A. Cordomi, K. Gkountelias, M. Papadokostaki, T. Mavromoustakos, D.E. Logothetis, A. N. Margioris, G. Liapakis, L. Pardo, G. Liapakis. Structural-Functional of the Analysis of the Third Transmembrane Domain of the Corticotropin-releasing Factor Type 1. J. Biol. Chem. 289,18966-18977 (2014).

150. D. Ntountaniotis, G. Agelis, A. Resvani, M. Halabalaki, G. Liapakis, K. Spyridaki, S. Golic Grdadolnik, F. Merzel, S. Kostidis, C. Potamitis, T. Tselios, J. Matsoukas, A. L. Skaltsounis, T. Mavromoustakos. An efficient synthetic method and theoretical calculations of olmesartan methyl ether: Study of biological function of AT1 antagonism in press Combinatorial Chemistry & High Throughput Screening in press.

152. E. Vrontaki, G. Melagraki, T. Mavromoustakos, A. Afantitis Exploiting ChEMBL database to identify indole analogues as HCV replication inhibitors. In press Methods, 2014.
153.E. Vrontaki, G. Leonis, A. Avramopoulos, M.G. Papadopoulos, M. Simcic, S.G. Grdadolnik, A. Afantitis, G. Melagraki, S.K. Hadjikakou, T. Mavromoustakos. Stability and binding effects of silver(I) complexes at lipoxygenase-1. Journal of Enzyme Inhibition and Medicinal Chemistry in press.

• 
  REVIEW ARTICLES IN JOURNALS
  

 

154.T. Mavromoustakos, V. Apostolopoulos, J. Matsoukas. Antihypertensive drugs that act on Renin-Angiotensin System with emphasis in AT₁ antagonists Mini Rev. Med. Chem. 1, 207-217 (2001).

155.J. Matsoukas, T. Mavromoustakos, V. Apostolopoulos, Designing peptide mimetics for the treatment of multiple sclerosis, Mini Rev. Med. Chem. 1, 273-282 (2001).
156.V. Apostolopoulos, J. Matsoukas, M. Plebanski, T. Mavromoustakos, Applications of Peptide Mimetics in Cancer. Curr. Med. Chem. 9, 411-420 (2002).
157.T. Mavromoustakos, P. Zoumpoulakis, I. Kyrikou, A. Zoga, E. Siapi, M. Zervou, I. Daliani, D. Dimitriou, A. Pitsas, C. Kamoutsis, P. Laggner.Efforts to Understand the Molecular Basis of Hypertension Trough Drug:Membrane Interactions. Current Topics in Medicinal Chemistry, 4, 445-459 (2004).

158.T. Mavromoustakos, M. Zervou, P. Zoumpoulakis, I. Kyrikou, N.P. Benetis, L. Polevaya, P. Roumelioti, N. Giatas, A. Zoga, P. Moutevelis Minakakis, A. Kolocouris, D. Vlahakos, S. Golic Grdadolnik, J. Matsoukas. Conformation and Bioactivity. Design and Discovery of Novel Antihypertensive Drugs. Current Topics in Medicinal Chemistry, 4, 385-401, (2004).

 

159.K.P. Marathias, B. Agroyannis, T. Mavromoustakos, J. Matsoukas,D.V. Vlahakos. Hematocrit-lowering Effect Following Inactivation of Renin-Angiotensin System with Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers. Current Topics in Medicinal Chemistry, 4, 483-486 (2004).

 

160.T. Mavromoustakos, A. Kapou, N.P. Benetis, M. Zervou. Conformational Analysis Using 2D NMR Spectroscopy Coupled with Computational Analysis as an Aid in the Alignment Procedure of 3D-QSAR studies. Drug Design Reviews-Online 1(3) 235-245 (2004).
161.E.D. Manzourani, T.M. Mavromoustakos, J.A. Platts, J.M. Matsoukas, T.V. Tselios. Structural Requirements for Binding of Myelin Basic Protein (MBP) Peptides to MHC II: Effects on Immune Regulation. Current Medicinal Chemistry, 12, 1521-1535 (2005).
162.P. Zoumpoulakis and T. Mavromoustakos. Seeking the Active Site of the AT₁ Receptor for Computational Docking. Drug Design Reviews-Online. 2, 537-544, (2005).
163.T. Mavromoustakos, S. Durdagi, C. Koukoulitsa, M. Simcic, M.G. Papadopoulos, M. Hodoscek, S. Golic Grdadolnik. Strategies in the Rational Drug Design. Current Medicinal Chemistry, 18, 2517-2530 (2011).
164.V.D. Mouchlis, E. Barbayianni, T.M. Mavromoustakos and G. Kokotos. The Application of Rational Design on Phospholipase A2 Inhibitors. Current Medicinal Chemistry, 18, 2566-2582 (2011).
165. T. Mavromoustakos, G. Aggelis, S. Durdagi, AT1 antagonists: a patent review (2008-2012). Expert Opin. Ther. Patents 23(11), 1-12 (2013).

        ORIGINAL AND REVIEW ARTICLES IN BOOKS

 

166.A. Makriyannis, T. Mavromoustakos, H. Jarrel, H. Banijamali: Role of the phenolic hydroxyl group in psychoactive cannabinoids. Studies on the interaction of Δ⁸-tetrahydrocannabinol and its O-methyl ether with model membranes, Marihuana '87. G. Chester, P. Consroe, R. Musty, eds Australian Govt Publishing Service, Canberra 1988 pp. 321-326.

167.A. Makriyannis, D.P. Yang, T. Mavromoustakos: The molecular features of membrane perturbation by anaesthetic steroids: a study using differential scanning calorimetry, small angle x-ray diffraction and solid state ²H "Steroids and Neuronal Activity" Ciba Foundation Symp. No. 153. J. Wiley London 172-189 (1990).
168.A. Makriyannis, D.P. Yang, T. Mavromoustakos: Combined Use of Solid State Nuclear Magnetic Resonance, Small Angle X-ray Diffraction and Differential Scanning Calorimetry in Studies of Cannabinoid:Membrane Interactions. Emerging Technologies and New Directions in Drug Abuse Research 106-128 (1991).

169.A. L. Petrou, M. Kollia, A.I. Scourti, M. Chrycikopoulou, T. Mavromoustakos, E. Theodoropoulou, M.H. Karatza, J.M. Tsangaris. Complexes of Aluminium(III) with biologically important ligands. NATO series: Advanced Study Institute on Cytotoxic, Mutogenic and Carcinogenic Potential of Heavy Metals Related to Human Environment 253-263 (1997), Kluwer Academic Publishers. N. Hadjiiliadis ed.

 

170.A. Kolocouris, M. Zervou, T. Mavromoustakos, P. Roumelioti, T. Tselios, J. Matsoukas, E. Humpher, Conformational analysis of peptidic and peptidomimetic AII antagonists using a combination of NMR spectroscopy and theoretical calculations Bioactive Peptides in Drug Discovery and Design: Medical Aspects vol. 22, 3-12 (1999). IOS Press. Ed. J. Matsoukas, T. Mavromoustakos.

171.T. Mavromoustakos, I. Daliani, J. Matsoukas. The application of biophysical methods to study Drug:Membrane Interactions Bioactive Peptides in Drug Discovery and Design: Medical Aspects vol. 22, 13-24 (1999). IOS Press. Ed. J. Matsoukas, T. Mavromoustakos.
172.N. Giatas, P. Roumelioti, T. Mavromoustakos, J. Matsoukas. Peptide Conformation and the Design of Mimetics: From Angiotensin to non-Peptide Receptor Antagonist. 2^nd Hellenic Forum on Bioactive Peptides, 335-342 (2001). Ed. P. Cordopatis.

 

173.I. Daliani, M. Zervou, P. Zoumboulakis, A. Kolocouris, S.G. Grdadolnik, T. Mavromoustakos. Interactions of AT₁ Antagonist Losartan with Phospholipid Bilayers Using MAS ¹³C NMR Spectroscopy. 2^nd Hellenic Forum on Bioactive Peptides, 455-460 (2001). Ed. P. Cordopatis.

174.T. Mavromoustakos, M. Zervou, A. Kolocouris, P. Zoumboulakis, S.G. Grdadolnik, P. Roumelioti, J. Matsoukas. Can Nuclear Magnetic Resonance Be of Aid to Treat Hypertension? 2^nd Hellenic Forum on Bioactive Peptides, 461-466 (2001). Ed. P. Cordopatis.

 

175.L. Polevaya, P. Roumelioti, T. Mavromoustakos, P. Zoumpoulakis, N. Giatas, I. Mutule, T. Keivish, A. Zoga, D. Vlahakos, E. Iliodromitis, D. Kremastinos, J. Matsoukas. Design, Synthesis and Biological Evaluation of Cyclic Angiotensin II Analogues with 3,5 Side-Chain Bridges: Role of C-Terminal Aromatic Residue and Positions. Bioactive Peptides in Drug Discovery and Design: Medical Aspects 3-12 (2002). vol. 55, IOS Press. Ed. J. Matsoukas, T. Mavromoustakos.

176.S. Deraeos, T. Tselios, P. Zoumpoulakis, L. Probert, A. Troganis, T. Mavromoustakos, J. Matsoukas. Design, Synthesis and Conformational Properties of Linear Analogues of Human Myelin Basic Protein Epitope MBP_1-11^. Bioactive Peptides in Drug Discovery and Design: Medical Aspects 116-124 (2002). vol. 55, IOS Press. Ed. J. Matsoukas, T. Mavromoustakos.

 

177.H. Wasmadeh, C. Demetzos, I. Daliani, T. Mavromoustakos, G. Nounesis, A. Tsortos. The Effects of Vinblastine Sulfate on Dipalmitoylphosphatidylcholine Single and Multiple Bilayer Membranes. Bioactive Peptides in Drug Discovery and Design: Medical Aspects 125-130 (2002). vol. 55, IOS Press. Ed. J. Matsoukas, T. Mavromoustakos.

 

178.I. Kyrikou, T. Mavromoustakos, C. Poulos. Structural Elucidation, Conformational Properties and Effects in Membrane Bilayers of the Toxin Paralysin, β-Ala-Tyr from Larvae of the Gray Flesh Fly. Bioactive Peptides in Drug Discovery and Design: Medical Aspects 142-149 (2002). vol. 55, IOS Press. Ed. J. Matsoukas, T. Mavromoustakos.

 

179.T. Mavromoustakos, I. Kyrikou, A. Kapou, D. Kovala. Effects of NSAIDs in Membrane Bilayers. Bioactive Peptides in Drug Discovery and Design: Medical Aspects 150-160 (2002). vol. 55, IOS Press. Ed. J. Matsoukas, T. Mavromoustakos.

 

180.A. Kapou, T. Mavromoustakos, S.G. Grdadolnik, S. Nikolaropoulos. Synthesis and Conformational Analysis of Steroidal Carriers of Alkylating Agents with the Use of Two-Dimensional Nuclear Magnetic Resonance. Bioactive Peptides in Drug Discovery and Design: Medical Aspects 167-173 (2002). vol. 55, IOS Press. Ed. J. Matsoukas, T. Mavromoustakos.

 

181.P. Zoumpoulakis, M. Zervou, T. Mavromoustakos, S.G. Grdadolnik. Structure Elucidation and Conformational Properties of Irbesartan. Bioactive Peptides in Drug Discovery and Design: Medical Aspects 174-179 (2002). vol. 55, IOS Press. Ed. J. Matsoukas, T. Mavromoustakos.

 

182.I. Kyrikou, M. Zervou, P. Petrakis, T. Mavromoustakos. An Effort to Develop an Analytical Method to Detect Adulteration of Olive Oil by Hazelnut Oil. Magnetic Resonance in Food Science. 223-230 Editors: P.S. Belton, A.M. Gil, G.A. Webb, D. Rutledge. Atjemaeum Press Ltd, Gateshead, Tyne and Wear, UK, 2003.

 

183.T. Mavromoustakos, P. Zoumpoulakis, M. Zervou, I. Kyrikou, A. Kapou, N. Benetis.The Use of Computational Analysis to Design Novel Drugs. Proceedings of the ICCMSE 2003 by World Scientific, 413-417 editor: T.E. Simos .

 

184.T. Tselios, S. Deraos, I. Daliani, G. Deraos, T. Mavromoustakos, L. Rrobert, J. Matsoukas. Design and Synthesis of Potent Human Cyclic MBP87-99 Altered Peptide Ligands: Inhibition of Experimental Allergic Encephalomyelitis (EAE). 3^rd Hellenic Forum on Bioactive Peptides 227-234 (2003) Ed. P. Cordopatis, E. Manessi, Z.G. Pairas.

 

185.N. Giatas, P. Roumelioti, A. Zoga, M.E. Androutsou, L. Polevaya, I. Mutule, T. Keivish, T. Mavromoustakos, P. Zoumpoulakis, D. Vlahakos, J. Matsoukas. Structural Resemblance of Angiotensin II Ring Cluster Conformation with AT₁ Non-Peptide Antagonists 3^rd Hellenic Forum on Bioactive Peptides 361-366 (2003) Ed. P. Cordopatis, E. Manessi, Z.G. Pairas.

 

186.P. Zoumpoulakis, M. Zervou, I. Kyrikou, S.G. Grdadolnik, P. Roumelioti, A. Zoga, N. Giatas, J. Matsoukas, T. Mavromoustakos. Comparative Conformational Analysis Between Losartan Derivatives. 3^rd Hellenic Forum on Bioactive Peptides 367-370 (2003) Ed. P. Cordopatis, E. Manessi, Z.G. Pairas.

 

187.I. Kyrikou, S.G. Grdadolnik, C. Poulos, T. Mavromoustakos. Structural Elucidation, Conformational Properties in Hydrophilic and Amphoteric Environments and Interactions With Phospholipid Bilayers of the Toxin Paralysin β-Ala-Tyr From Larvae of the Gray Flesh Fly. 3^rd Hellenic Forum on Bioactive Peptides 371-375(2003) Ed. P. Cordopatis, E. Manessi, Z.G. Pairas.

 

188.P. Zoumpoulakis, M. Zervou, I. Kyrikou, E. Siapi, S.G. Grdadolnik, P. Laggner, A. Hickel, T. Mavromoustakos. Relationship Between Conformation and Bioactivity in the Hypertension Disease. 3^rd Hellenic Forum on Bioactive Peptides 355-360 (2003) Ed. P. Cordopatis, E. Manessi, Z.G. Pairas.

 

189.S. Deraos, T. Tselios, I. Daliani, P. Zoumpoulakis, L. Probert, A. Troganis, T. Mavromoustakos, J. Matsoukas. Human Myelin Basic Protein Epitope MBP_1-11: Synthesiss and Conformationa Analysis of Altered Peptide Ligands. 3rd Hellenic Forum on Bioactive Peptides 601-605 (2003) Ed. P. Cordopatis, E. Manessi, Z.G. Pairas.

190.T. Mavromoustakos, M. Zervou, P. Zoumpoulakis. Design and Discovery of Novel Antihypertensive Drugs through Conformation and Bioactivity Studies. Bentham Science Publishers Ltd. Co-Editors:Atta-ur-Rahman, Allen B. Reitz. Associate Editors: M. Iqbal Choundhary, Cheryl P. Kordik. Ur Frontiers in Medicinal Chemistry, 3, 87-113 (2006).
191.T. Mavromoustakos. The Use of Differential Scanning Calorimetry to Study Drug-Membrane Interactions. Methods in Molecular Biology, vol 400. Methods in Membrane Lipids. Edited by A.M. Dopico, Humana Press Inc., Tuttowas, NJ. pages 587-600 (chapter 39) (2008).