Thomas mavromoustakos

VISITS AND SPECIALISATION AFTER PH.D STUDIES

1. 
   Specialisation in the Computational Analysis and Molecular Modeling at Prof. Rod Hubbard’s laboratory (York University, Summer of 1992).
   
2. 
   Invited visit to Prof. Peter’s Laggner laboratory in order to perform small and wide angle x-ray diffraction experiments. The results from this visit are published in the Biochim. Biophys. Acta (Summer of 1996).
   
3. 
   Modern Experimental techniques using NMR spectrometer of AMX 500 MHz and use of modern software to process the experimental data (University of Connecticut, Summer of 1999).
   
4. 
   Biological experiments related to the binding of novel AT1 antagonists at AT1 and AT2 receptors as well as cell cultures (University of Leeds, Summer of 2004).
   
5. 
   Visits in the Synchrotron facilities of Trieste, Italy to perform x-ray expreriments (Summers 2007, 2009).
   
6. 
   Visits of National Institute of Chemistry, Ljubluana, Slovenia (Summers of 2010 and 2012)
   
7. 
   Visit of BMRZ in Frankfurt of Germany, (2011,2013,2014) running solid state NMR experiments using Bruker 600 and 850 MHz spectrometers.
   

FUNDING-WORKSHOPS
1. Coordinator of a funded research project by the European Community entitled “Molecular Characterization of Virgin Olive Oil” (148.000 ECU).
2. Participation in the funded research project by the European Community entitled Development and Assessment of Methods for the Detection of Adulteration of Olive Oil with Hazelnut Oil GROWTH (MEDEO 2001).
3. Co-organization of a workshop with Maria Zervou held in Athens on November 22, 1996 about the “Use of Isotope Analyses Applications in Food and Beverage Authentication. Detection of Adulteration.” In this workshop six speakers from France, German and England informed the audience about the new techniques in the analyses and detection of adulteration of foods and beverages. The audience consisted of seventy scientists from Greece and Cyprus working in Food and Beverage Industry, Govermental Organizations related to Food and Beverage Control and Greek Universities.
4.Participation as a co-ordinator or participant in 28 funded research projects by the General Secretary of Greece and European Community (EPAN, PAVET, ENTER, bilateral, HERAKLEITOS, etc).
5.Organization of a partners participating in the MEDEO program which is referred to Development of Novel Methods to Detect Adulteration of Olive Oil by Hazelnut Oil (November 2001).
6.Participation in COST D22 and COST D26 programs. Acquire SMT mission.
7.Participation as a co-ordinator in a research project funded by the Institute of Promotion of Research in Cyprus entitled “New Approaches to face Psoriasis” and bilateral collaborations between Cyprus with Slovenia and Romania.
8.Co-organisation with S. Mavromoustakos in Cyprus a scientific conference to honour Prof. D. Poulter (3.11.2008).
9. September 17^th 2010. Co-organisation with Schrodinger a workshop entitled “From Structural Biology to Drug Discovery”. In this workshop 85 researchers and professors from all over Greece participated actively.
10. Chairman with Prof. A. Tsotinis for organizing the international 29th Cyprus-Camerino-Noordwijkerhout Trends in Drug Research ” conference at Limassol-Cyprus between 2-7 September 2012.

11. Member of the organizing committee of the 32^nd European Conference of Peptide Chemistry ( September Athens 2-7, 2012).

12. Participation as a co-ordinator and participant in 3 funded research projects by Institute of Promotion of Research in Cyprus with University of Cyprus or Institute of Technology.

13. Participation in the Marie Curie Actions EURODAISY. MEST/CT2005/020575. In that action I guided with Dr. M. Papadopoulos S. Durdagi who is now Professor in the Behcesehir University in Istanbul.

14.Participation in COST, EAST-NMR and BIO-NMR programs.

15. Chairman with Prof. A. Tsotinis for organizing the international 29th Cyprus-Camerino-Noordwijkerhout Trends in Drug Research ” conference at Limassol-Cyprus between 18-22 Μay 2014.

GREEK PATENTS
1.T. Mavromoustakos, G. Bonas, M. Zervou, E. Theodoropoulou. A new method to detect Adulteration of Virgin Olive Oil (No 1002879).
2.T. Mavromoustakos, G. Kokotos, P. Minakaki. Novel Antihypertensive Drugs (No 1004905).
 

PUBLISHED BOOKS (Greek language)
1. T. Mavromoustakos, J.M. Matsoukas. Nuclear Magnetic Resonance.

• 
  Design of Pharmaceutical Molecules.
  
• 
  Applications in Medicine, Food and Beverage Chemistry January 1999.
  

2. T. Mavromoustakos, A. Kolocouris, C. Papakonstantinou, P. Sinigalias, C. Lappas. Two textbooks in Chemistry for the third class of high school . They are published in August of 1998 and are distributed in all high schools of Greece.

3.T. Mavromoustakos, A. Kolocouris, C. Papakonstantinou, P. Sinigalias, C. Lappas. A Chemistry laboratory guide for the third class of high school . They are published in August of 1998 and are distributed in all high schools of Greece.
4.T. Mavromoustakos, A. Kolocouris, C. Papakonstantinou, P. Sinigalias, C. Lappas. Two books containing solutions of the exercises in the textbooks. They are published in August of 1998 and are distributed in all high schools of Greece.
5.T. Mavromoustakos. Use of the NMR in the study of pharmaceutical substances, zeolithes, polymers and archaelogical findings. January 2001.
6.T. Mavromoustakos, J. Matsoukas. NMR spectroscopy . Application in Medicine, Pharmaceutical Chemistry, Biochemistry and Food and Beverage Chemistry (2006).
7. T. Mavromoustakos and P. Zoumpoulakis.. Molecular Modeling. Applications in Organic and Pharmaceutical Chemistry (pages 307) ΙSΒΝ 978-960-89486-5- (2008).
8. T. Mavromoustakos, T. Tselios and C. Papakonstantinou. Fundamental Principles of Organic Chemistry, Ed. Symmetria, Athens 2014.

Editor
1.Bioactive Peptides in Drug Discovery and Design: Medical Aspects. This book was published by IOS press in January of 1999 as the 22^nd volume of a series of books entitled «Biomedical and Health Research”. Eds. J. Matsoukas, T. Mavromoustakos.
2.Review of Clinical Pharmacology and Pharmacokinetics vol. 11, 1997. An issue dedicated in Peptides and Biomedical Research. Eds. J. Matsoukas, T. Mavromoustakos
3.Bioactive Peptides in Drug Discovery and Design: Medical Aspects.This book is in press 2002 in as the 55^th volume of a series of books entitled «Biomedical and Health Research”. Eds. J. Matsoukas, T. Mavromoustakos.

4.Guest Editor in Current Reviews in Medicinal Chemistry and more particularly in the issue dedicated to hypertension («Modern Aspects in the Design and Discovery of Novel Antihypertensive Drugs, 2004». The contributors of this issue included well known scientists of Greece, Europe and USA.

5.Guest Editor in Current Medicinal Chemistyr volume 18(17), 2011. Methodologies and Applied Strategiew in the Rationa Drug Design.

Graduate Students acquired Ph.D or Msc that performed the experimental work under my supervision

1.E. Theodoropoulou, Ph.D. (1994-1997) 2. E. Matsouka, Ph.D. (2000-2001) 3. I. Daliani, Ph.D. (1998-2002) 4. M. Zervou Ph.D. (1998-2002) 5. I. Kyrikou, Msc (1999-2001) 6. I. Kyrikou, Ph.D. (2001-2004) 6. A. Zoga, Ph.D (2000-2004) 7. P. Zoumpoulakis, Ph.D. (2000-2005) 8. E. Mantzourani, Ph.D (2002-2007) 9. A. Kapou, Msc. (1999-2001) 10. A. Kapou, Ph.D. (2002-2007) 12. K. Pelekoukias, Msc. (2001-2002) 13.M. Smyrniotakis, Msc. (2002-2003) 14. G. Mouselimi, Msc (2003-2004) 15. I. Touris, Msc (2003-2004) 16. S. Gega, Msc. (2003-2005) 17. E. Chalkefs Msc. (2004-2006) 18. V. Mouchlis, Msc. (2005-2007) 19. C. Fotakis Msc. (2005-2007) 20. A. Politi, Msc. (2006-2007) 21. S. Durdagi (2006-2009). 22. A. Politi (Ph.D) (2007-2009) 23. C. Potamitis Ph.D. (2006-2009) 24. N. Neophytou Msc. (2008-2010) 25. V. Michopoulou Msc. (2008-2010) 26. V. Mouchlis Ph.D. (2007-2010) 27. X. Ntaltagianni (Msc.) (2010-2011) 28. N. Stavrinoudakis (Msc.) (2009-2011) 29. N. Varvarigou Msc. (2009-2011, 30. E. Kritsi Msc. (2010-2012) 31. E. Vrontaki, Msc. (2010-2012) 32. T. Kellici Msc. (2011-2013) 33. P. Kolocotroni Msc. (2011-2013) 34. D. Ntountaniotis (2007-2012) 35. P. Chatzigeorgiou Ph.D. (207-2012) 36. J. Andreadelis (Msc) 37. E. Koulouridi (Msc) 38. C. Tzoupis (Ph.D.) 39. C. Koukoulitsa (Ph.D.).

Undergraduate Students that finished their diploma work under my supervision : Gili, A., Vasiliki, V., Argyriou, G., Gianni, M., Stougiannou, E., Vasiliou, V., Vatougia, G., Kritsi, E., Thanopoulos C., Xenos, I., Stavroula X., Maniati A., Brontaki, E. Stamelaki, V., N. Moustakas, L. Kokkinakis, C. Papaioannou, S. Mathioudaki, M Vanioti, L. Katsillis, M. Panopoulou, G. Skoufas, J. Tselios

Activity in Education

1. 
   Participation in different educational programs for teaching graduate students various aspects of Medicinal Chemistry and NMR spectroscopy (EPEAEK programs).
   

1. 
   University of Patras, 1999 (Co-ordinator Prof. J. Matsoukas. Medicinal Chemistry, Drug Discovery and Design.)
   
2. 
   University of Athens (Co-ordinator Prof. N. Xatdjichristidis, Polymer Science).
   
3. 
   University of Ioannina, 2002-2003 (Co-ordinator Prof. N. Xatjihiliadis. Bioinorganic Chemistry).
   
4. 
   University of Athens 2003-2005 (Co-ordinator Prof. G. Kokotos, Organic Synthesis and Application in the Industry).
   

Teaching at the University of Cyprus at Chemistry Department of undergraduate courses.

• 
  Laboratory of Organic Chemistry (553).
  
• 
  Introduction in the Medicinal Chemistry (472)
  

Teaching at the University of Athens

• 
  Organic Chemistry (Undergraduate Course)
  
• 
  NMR spectroscopy and Molecular Modeling (Graduate Course)
  
• 
  Organic Chemistry for Physicists
  
• 
  Bioorganic Chemistry (Organic Spectroscopy and Principles of Molecular Modeling)
  

 

Seminars to high school teachers

• 
  Seminars on the Modern Organic Chemistry and applications (May 1998).
  
• 
  Guidelines on the philosophy of the written chemistry books for the high school students.
  
• 
  Learning Chemdraw and Power Point (November 2008)
  

Seminar for the scientists working in the Cyprus industry for food and beverages.

• 
  Applications of Nuclear Magnetic Resonance as an aid to solve existing problems in industry.
  

Participation

 

• 
  Member of Research Committee for two Ph.D. students of Cyprus University and several students of Greek Universities. I am also participating as one of the majors advisors of the student S. Durdagi who will get Ph.D diploma from Frei University.
  

LIST OF PUBLICATIONS
        PUBLICATION IN JOURNALS

 

1. C.J. Van der Schyf, T. Mavromoustakos, A. Makriyannis: The conformation of (-)-8α- and (-)-8α-hydroxy-Δ⁹-tetrahydrocannabinols and their interactions with model membranes. Life Sci. 42: 2231-2239 (1988).

2. T. Mavromoustakos, D.P Yang, A. Charalambous, L.G. Herbette, A. Makriyannis: Study of the topography of cannabinoids using x-ray diffraction. BBA M BIO 1024:336-344 (1990).
 

3.T. Mavromoustakos, D.P. Yang, W. Broderick, D. Fournier, L.G. Herbette, A. Makriyannis: Small Angle X-Ray Diffraction Studies on the Topography of cannabinoids in Synaptic Plasma Membranes. Pharmacol. Biochem. Be. 40, 547-552 (1991).

 

4.D.W. Chester, V. Skita, H.S. Young, T. Mavromoustakos, P. Shrittmatter: Bilayer structure and physical dynamics of the cytochrome b₅ dimyristoylphosphatidylcholine interaction. Biophys. J. 61, 1224-1243 (1992).

 

5.D.P. Yang, T. Mavromoustakos, K. Beshah, A. Makriyannis: Amphipathic interactions of cannabinoids with membranes. A comparison of cannabinoids with membranes. A comparison between Δ⁸-THC and its O-methyl analog using differential scanning calorimetry, X-ray diffraction and solid state ²H-NMR. BBA M BIO 1103, 25-36 (1992).

 

6.D.P. Yang, T. Mavromoustakos, A. Makriyannis: Small Angle X-Ray Diffraction Studies of Δ⁸-tetrahydrocannabinol and its O-Methyl Analog in Membranes. Life Sci 53, 117-122 (1993).

 

7.P. Martel, A. Makriyannis, T. Mavromoustakos, K. Kelly and K.R. Jeffrey: Topography of tetrahydrocannabinol in model membranes using neutron diffraction. BBA M BIO 1151, 51-58 (1993).

 

8.J. Matsoukas, J. Hondrelis, M. Keramida, T. Mavromoustakos, A. Makriyannis R. Yamdagni, Q. Wu, G. Moore: Role of the NH₂-terminal Domain of ANG II and [Sar¹] ANG II on Conformation and Activity: NMR Evidence for Aromatic Ring Clustering and Peptide Backbone Folding Compared to [Des^1,2,3] ANG II J. Biol. Chem. 269, 5303-5312 (1994).

 

9. T. Mavromoustakos, De-Ping Yang, A. Makriyannis. Topography of Alphaxalone and Δ¹⁶-alphaxalone in Membrane Bilayers containing cholesterol BBA M BIO 1194(1), 69-74 (1994).

10.T. Mavromoustakos, De-Ping Yang, E. Theodoropoulou, A. Makriyannis. Studies of the Conformational Properties of the Cannabinmimetic Aminoalkylindole Pravadoline Using NMR and Molecular Modeling. Eur. J. Med. Chem 30(3), 227-234 (1995).

11.T. Mavromoustakos, D.P. Yang, A. Makriyannis: Small angle x-ray diffraction and differential scanning calorimetric studies on O-methyl-(-)-Δ⁸-Tetrahydrocannabinol and its 5' iodinated derivative in membrane bilayers BBA M BIO 1237, 183-188 (1995).

12.T. Mavromoustakos, D.P. Yang, A. Makriyannis: Effects of the anesthetic steroids alphaxalone and its inactive analog Δ¹⁶-analog on the thermotropic properties of membrane bilayers. A model for membrane perturbation. BBA M BIO 1239(2), 257-264 (1995).

 

13.J. M. Matsoukas, G. Agelis, A. Wahhab, J. Hondrelis, D. Panagiotopoulos, R. Yamdagni, Q. Wu, T. Mavromoustakos, H.L.S. Maia, R. Ganter, G.J. Moore. Differences in backbone structure between angiotensin II agonists and type I antagonists. J. Med. Chem. 38(23), 4660-4669 (1995).

 

14.T. Mavromoustakos, E. Theodoropoulou, D. Papahatjis, T. Kourouli, De-Ping Yang, M. Trumbore, A. Makriyannis: Studies on the thermotropic effects of cannabinoids on phosphatidylcholine bilayers using differential scanning calorimetry and small angle X-ray diffraction. BBA M BIO 1281(2), 235-244 (1996).

15.A. Ioannou, A. Dimirkou, T. Mavromoustakos. Isotherms of phosphate sorption by hematite and bentonite-hematite (b-h) system Commun. Soil Sci. Plant Anal. 27(5-8), 1901-1924 (1996).

16. M. Koufaki, T. Calogeropoulou, T. Mavromoustakos, E. Theodoropoulou, A. Tsotinis, A. Makriyannis. Synthesis of ²H-Labelled Alkoxyethyl Phosphodiester AZT Derivatives for Solid-State ²H-NMR Studies. J. Heterocyclic Chem. 33, 619-622 (1996).

 

17. J.M. Matsoukas, D. Panagiotopoulos, M. Keramida, T. Mavromoustakos, R. Yamdagni, Q. Wu, G.J. Moore, M. Saifeddine, M. D. Hollenberg: Synthesis and Contractile Activities of Cyclic Thrombin Receptor Derived Peptide Analogues with a Phe-Leu-Leu-Arg Motif: Importance of the Phe /Arg Relative Conformation and the Primary Amino Group for Activity. J. Med. Chem. 39, 18, 3585-3591 (1996).

 

18.Τ. Mavromoustakos, E. Theodoropoulou, De-Ping Yang, Sonyyan Lin, M. Koufaki, A. Makriyannis. The conformational properties of the Antineoplastic Ether Lipid 1-thiohexadecyl-2-O-methyl-rac-glycero-3-phosphocholine Chem. Phys. Lipids 84, 1, 21-34 (1996).

 

19.T. Mavromoustakos, D.P. Yang, A. Makriyannis. Topography and thermotropic properties of cannabinoids in brain sphingomyelin bilayer Life Sci. 59, 23, 1969-1979 (1996).

 

20.T. Mavromoustakos, E. Theodoropoulou, C. Dimitriou, J. Matsoukas, D. Panagiotopoulos, A. Makriyannis. Interactions of Angiotensin II with Membranes using a combination of Differential Scanning Calorimetry and ³¹P-NMR spectroscopy LIPS 3(4), 175-180 (1996).

 

21.E. Theodoropoulou, T. Mavromoustakos, D. Panagiotopoulos, J. Matsoukas, J. Smith. Superimposition of potent non-peptide AT₁ receptor antagonists with angiotensin II. LIPS 3, 209-216 (1996).

22.D. Panagiotopoulos, J. Matsoukas, K. Alexopoulos, A. Zebeki, T. Mavro moustakos, M. Saifeddine, M. Hollenberg. Synthesis and activities of cyclic thrombin-receptor-derived peptide analogues of the Ser₄₂-Phe-Leu-Leu-Arg₄₆ motif sequence containing D-Phe and/or D-Arg. LIPS 3, 233-240 (1996).

 23.A. Vyza, E. Tsitsa, E. Theodoropoulou, T. Mavromoustakos. Complexation of new active antibacterial adamantan derivatives with β-CD:Preparation and characterization of complexes. Study of the thermotropic properties of pure and complex form with dipalmitoyl phosphatidylcholine bilayers. JOU INC PHE MOL, 25 337-340 (1996).

24.J.Matsoukas, M.D. Hollenberg, T. Mavromoustakos, D. Panagiotiopoulos, K. Alexopoulos, R. Yamdagni, Q. Wu, G.J. Moore. Conformational Analysis of the Thrombin Receptor Agonist Peptides SFLLR and SFLLR-ΝH₂ by NMR: Evidence for a Cyclic Bioactive Conformation. J. Protein Chem. 16, 2, 113-131 (1997).

 25.T.Mavromoustakos, E. Theodoropoulou, De-Ping Yang. The use of high-resolution solid-state NMR spectroscopy and differential scanning calorimetry to study interactions of anaesthetic steroids with membrane. BBA M BIO 1328(1), 65-73 (1997).
 

26.J.M. Matsoukas, M. Keramida, D. Panagiotopoulos, T. Mavromoustakos, HLS Maia, G. Bigam, D. Pati, H. Hoang, H.H Habibi, G.J. Moore. Structure elucidation and conformational analysis of gonadotropin releasing hormone and its novel synthetic analogue [Tyr(OMe)⁵, D-Lys⁶, Aze⁹NHEt]GnRH: The importance of aromatic clustering in the receptor binding activity. Eur. J. Med. Chem. 32(12), 927-940 (1997).

 

27.T. Mavromoustakos, M. Zervou, E. Theodoropoulou, D. Panagiotopoulos, G. Bonas, M. Day, A. Helmis. ¹³C NMR Analysis of the Triacylglycerol Composition of Greek Virgin Olive Oils Magn. Reson. Chem. 35, S3-S7 (1997).

 

28.T. Mavromoustakos, I.K. Stamos, Ch. Kamoutsis, E. Theodoropoulou, M. Zervou, E. Humpfer. Nuclear Magnetic Resonance Spectral Analysis and Conformational Properties of 11-Benzoyl-9,9a,10,11-tetrahydro-4H-indolo[4,4-ab] carbazole J. Pharmaceut. Biomed. 16(5) 723-732 (1998).

 

29.T.Mavromoustakos, M. Zervou, D. Panagiotopoulos, E. Theodoropoulou, J. Matsoukas, D. Karussis. Structure Elucidation and Conformational Properties of the Immunomodulator Linomide J. Pharmaceut. Biomed. 16(5) 741-751 (1998).

 

30.T. Mavromoustakos, A. Papadopoulos, E. Theodoropoulou, C. Dimitriou, E.A. Byza. Thermal Properties of Adamantanol Derivatives and Their β-Cyclodextrin Complexes in Phosphatidylcholine Bilayers. Life Sci. 62(20), 1901-1910 (1998).

 

31.Alexopoulos, J. Matsoukas, T. Tselios, P. Roumelioti, T. Mavromoustakos, K. Holada. A comparative SAR study of Thrombin receptor derived non peptide mimetics. Importance of phenyl/guanidino Proximity for activity Amino Acids 15, 211-220 (1998).

 

32.T. Mavromoustakos, E. Theodoropoulou. A combined use of ¹³C-cross polarization/magic angle spinning, ¹³C- magic angle spinning and ³¹P-nuclear magnetic spectroscopy with Differential Scanning Calorimetry to study cannabinoid-membrane interactions. Chem. Phys. Lipids 92(1), 37-52 (1998).

 

33.T. Mavromoustakos, E. Theodoropoulou, M. Zervou, T. Kourouli, D. Papahatjis. Structure Elucidation and Conformational Properties of synthetic Cannabinoids 2-[6a,7,10,10a-tetrahydro-6,6,9-trimethyl-1-hydroxy-6H-dibenzo [b,d]pyranyl)-2-hexyl-1,3-dithiolane and its methylated analog. J. Pharmaceut. Biomed. 18(6), 947-956, (1999).

 

34.K.Alexopoulos, P. Fatseas, E. Melissari, D. Vlahakos, J. Smith, T. Mavromoustakos, M. Saifeddine, G. Moore, M. Hollenberg, J. Matsoukas. Design and Synthesis of Thrombin Receptor-derived Nonpeptide Mimetics Utilizing a Piperazine Scaffold. Bioorg. & Med. Chemistry 7(6), 1033-1041 (1999).

 

35.T. Mavromoustakos, A. Kolocouris, M. Zervou, P. Roumelioti, J. Matsoukas, R. Weisemann. An effort to understand the molecular basis of hypertension through the study of conformational analysis of losartan and sarmesin using a combination of Nuclear Magnetic Resonance spectroscopy and theoretical calculations J. Med. Chem. 42(10) 1714-1722 (1999).

 

36.T. Tselios, L. Probert, I. Daliani, E. Matsoukas, A. Troganis, I.P. Gerothanasis, T. Mavromoustakos, G.J. Moore, J.M. Matsoukas. Design and Synthesis of a Potent Cyclic Analogue of the Myelin Basic Protein Epitope MBP_72-85: Importance of the Ala⁸¹ Carboxyl Group and of a Cyclic Conformation for Induction of Experimental Allergic Encephalomyelitis J. Med. Chem. 42,7, 1170-1177 (1999).

 

37.T. Mavromoustakos, I. Daliani. Effects of Cannabinoids in membrane bilayers containing cholesterol. BBA M BIO. 1420, 252-265 (1999).

 

38.A. Kolocouris, D. Tataridis, G. Fytas, T. Mavromoustakos, G.B. Foscolos, N. Kolocouris, E.D. Clercq. Synthesis of 2-(2-adamantyl)piperidines and structure anti-influenza virus A activity relationship study using a combination of NMR spectroscopy and molecular modeling. Bioorg. & Med. Chem. Lett., 9(24), 3465-3470 (1999).

39.J..M. Matsoukas, L. Polevaya, J. Ancas, T. Mavromoustakos, A. Kolocouris, P. Roumelioti, D.V. Vlahakos, R. Yamdagni, Q. Wu, G.J. Moore. The Design and Synthesis of a Potent Angiotensin II Cyclic Analogue Confirms the Ring Cluster Receptor Conformation of the Hormone Angiotensin II Bioorg. & Med. Chem. Lett., 8(1), 1-10 (2000).
 

40.A.Troganis, I.P. Gerothanasis, Z. Athanassiou, T. Mavromoustakos, G.E. Hawkes, C. Sakarellos. Thermodynamic Origin of Cis/Trans Isomers of a Proline-Containing β-turn Model Dipeptide in Aqueous Solution: A Combined Variable Temperature ¹H-NMR, Two Dimensional ¹H, ¹H Gradient Enhanced Nuclear Overhauser Effect Spectroscopy (NOESY), One Dimensional Steady-State Intermolecular ¹³C, ¹H-NOE and Molecular Dynamics Study. Biopolymers 53, 72-83 (2000).

 

41.P.Roumelioti, T. Tselios, K. Alexopoulos, T. Mavromoustakos, A. Kolocouris, G.J. Moore, J.M. Matsoukas. Structural comparison between type I and type II antagonists: possible implications in the drug design of AT-1 antagonists Bioorg. & Med. Chem. Lett., 10(8), (2000) 755-758.

42.T. Mavromoustakos, M. Zervou, G. Bonas, A. Kolocouris, P.Petrakis. A Novel Analytical Method to Detect Adulteration of Virgin Olive Oil by Other Oils. J Am Oil Chem Soc 77(4) 405-411 (2000).
 

43.T. Tselios, I. Daliani, S. Deraos, S. Thymianou, E. Matsoukas, I. Gerothanasis, A. Troganis, A. Mouzaki, T. Mavromoustakos, L. Probert, J. Matsoukas. Treatment of Experimental Allergic Encephalomyelitis (EAE) by a Rationally Designed Cyclic Analogue of Myelin Basic Protein (MBP) Epitope 72-85 Bioorg. & Med. Chem. Lett., 10(24), 2713-2717 (2000).

 

44.K. Dimas, C. Demetzos, D. Angelopoulou, A. Kolokouris, T. Mavromoustakos. Biological Activity of Myricetin and Derivatives Against Human Leukemic Cell Lines in vitro. Pharmacol. Res., 42(5) 475-478 (2000).

45.Antonios Kolocouris, T. Mavromoustakos, Costas Demetzos, Aris Terzis, Simona Golic Grdadolnik Structure Elucidation and Conformational Properties of a Novel Bioactive Clerodane Diterpene Using a Combination of High Field NMR Spectroscopy, Computational Analysis and X-Ray Diffraction in Bioorg. Med. Chem. Lett. 11(6), 837-840 (2001).

46.K. Alexopoulos, D. Panagiotopoulos, T. Mavromoustakos, P. Fatseas, M.C. Paredes-Carbajal, D. Mascher, S. Mihailescu, J. Matsoukas. Design, Synthesis and Modeling of Novel Cyclic Thrombin Receptor Derived Peptide Analogues of the Ser₄₂-Phe-Leu-Leu-Arg₄₆ Motif Sequence with Fixed Conformations of Pharmacophoric Groups: Importance of a Phe/Arg/NH₂ Cluster for Receptor Activation and Implications in the Design of Non-Peptide Thrombin Receptor Mimetics. J. Med. Chem. 44, 328-339 (2001).

 

47.M. Matzapetakis, M. Kourgiantakis, M. Dakanali, C. P. Raptopoulou, A. Terzis, A. Lakatos, I. Banyai, T. Kiss, L. Iordanidis, T. Mavromoustakos, A. Salifoglou. Synthesis, pH-dependent Structural Characterization and Solution Behavior of Aqueous Aluminum and Gallium Citrate Complexes Inorg. Chem. 40, 1734-1744 (2001).

 

48.T. Mavromoustakos, D. Papahatjis, P. Laggner Differential Membrane Fluidization by Active and Inactive Cannabinoid analogs. BBA M BIO 1512(2) 183-190 (2001).

49.L. Polevaya, T. Mavromoustakos, P. Zoumboulakis, S. G. Grdadolnik, P. Roumelioti, N. Giatas, Ilze Mutule, T. Keivish, D. Vlahakos, E. Iliodromitis, D. Kremastinos, J. Synthesis and Study of Cyclic Angiotensin II Antagonist Analogue reveals the role of π*-π* interactions in the C-Terminal Aromatic Residue for agonist activity and its structure resemblance with AT₁ non-peptide antagonists. Matsoukas Bioorg. Med. Chem. 9, 1639-1647 (2001).

 

50.T. Mavromoustakos , T. Kalogeropoulou, M. Koufaki, A. Kolocouris, I. Daliani, C. Demetzos, Z. Meng, A. Makriyannis, J. Balzarini, E. De Clercq, Ether Phospholipid-AZT Conjugates Possessing Anti-HIV and Antitumor Cell Activity. Synthesis, Conformational Analysis, and Study of Their Thermal Effects on Membrane Bilayers. J. Med. Chem. 44, 1702-1709 (2001).

 

51.D.Angelopoulou, C. Demetzos, A. Kolocouris, I. Daliani, T. Mavromoustakos Structure Elucidation, Conformational Analysis and Thermal Effects of Αntimicrobial Myricetin Derivatives on Membrane Bilayers J. Heter. Chem. 38, 703-710 (2001).

 

52.C.Pappas, P.A. Tarantilis, I. Daliani, T. Mavromoustakos, M. Polysiou. Comparison of classical and ultrasound assisted isolation procedures of cellulose from Kenaf and Eucalyptus Ultrasonics 9(1), 19-23 (2002).

 

53.T. Tselios, V. Apostolopoulos, I. Daliani, S. Deraos, S. Grdadolnik, T. Mavromoustakos, M. Melachrinou, S. Thymianou, A. Mouzaki and J. Matsoukas. Antagonistic Effects of Human Cyclic MBP_87-99 Altered Peptide Ligands in Experimental Allergic Encephalomyelitis and Human T-cell Proliferation. J. Med. Chem. 45, 275-283 (2002).

 

54.P. Zoumpoulakis, S.G. Grdadolnik, J. Matsoukas. T. Mavromoustakos. Structure elucidation and conformational properties of eprosartan a non peptide Angiotensin II AT₁ antagonist. J. Pharmaceut. Biomed. Anal. 28, 125-135 (2002).

 

55.H. Maswadeh, C. Demetzos, K. Dimas, Y. L. Loukas, A. Georgopoulos, T. Mavromoustakos, C. Th. Papaiouannou. In vitro cytototoxic/cytostatic activity of anionic liposomes containing vinblastine against leukemic human cells. J. Pharm. Pharmacol. 54, 189-196 (2002).

56.S. Prispas, E.S. Kioulafa, N. Hadjichristidis, T. Mavromoustakos. Block copolymers with crystalline-amorphous, crystalline-polyeloctrolyte and amorphous-polyelectrolyte blocks Macromol. Chem. Phys. 203(10-11), 1317-1327, (2002).
 

57.P. Roumelioti, L. Polevaya, P. Zoumpoulakis, N. Giatas, T. Keivish, A. Haritonova, A. Zoga, D. Vlahakos, E. Iliodromitis, D. Kremastinos, S.G. Grdadolnik, T. Mavromoustakos, J. Matsoukas. Design, Synthesis and Biological Evaluation of Cyclic Angiotensin II Analogues with 3,5 Side Chain Bridges: Role of C-Terminal Aromatic Residue and Ring Cluster for Activity and Implications in the Drug Design of AT1 non Peptide Antagonists. Bioorg. Med. Chem. Letters 12, 2627-2633 (2002).

 

58.H. Maswadeh, C. Demetzos, I. Daliani, I.Kyrikou, T. Mavromoustakos. A. Tsortos, G. Nounesis. A molecular basis explanation of the dynamic and thermal effects of vinblastine sulfate upon dipalmitoylphosphatidylcholine bilayer membranes. BBA M BIO 1567 49-55 (2002).

59.N. Avlonitis, E. Lekka, A. Detsi, M. Koufaki, T. Calogeropoulou, E. Scoulica, E. Siapi, I. Kyrikou, T. Mavromoustakos, A. Tsotinis, S. Golic Grdadolnik, A. Makriyannis. Antileshmanial Ring-Substituted Ether Phospholipids. J. Med. Chem. 46, 755-767 (2003).

 

60.P. Zoumpoulakis, A. Zoga, P. Roumelioti, N. Giatas, S.G. Grdadolnik, E. Iliodromitis, D. Vlahakos, D. Kremastinos, J. Matsoukas, T. Mavromoustakos. Conformational and biological studies for a pair of novel synthetic AT₁ antagonists. Stereoelectronic requirements for antihypertensive efficacy J. Pharm. Biomed. Anal. 31 833-844 (2003).

 

61.I. Kyrikou, S.G. Grdadolnik, M. Tatari, C. Poulos, T. Mavromoustakos Structure Elucidation and Conformational Properties of Toxin Paralysin β-Ala-Tyr J. Pharm. Biomed. Anal. 31, 713-721 (2003).

62.P. Moutevelis-Minakakis, M. Gianni , H.Stougiannou , P. Zoumpoulakis, A.Zoga, A. D. Vlahakos, E. Iliodromitis, T. Mavromoustakos Design and Synthesis of Novel Antihypertensive Drugs Bioorg. Med. Chem. Letters 13(10), 1737-1740 (2003).

63.M. Dakanali, E.T. Kefalas, C. P. Raptopoulou, A. Terzis, T. Mavromoustakos, A. Salifoglou. Synthesis, Spectroscopic, and Structural Studies of a New Cadmium (II)-Citrate Aqueous Complex. Potential links to Cadmium toxicity. Inorg. Chem. 42, 2531-2537, (2003).

64.M. Dakanali, E.T. Kefalas, C.P. Raptopoulou, A. Terzis, G. Voyiatzis, I. Kyrikou, T. Mavromoustakos, A. Salifoglou. A New Dinuclear Ti(IV)-Peroxo-Citrate Complex from Aqueous Solutions. Synthetic, Structural, and Spectroscopic Studies in Relevance to Aqueous Titanium(IV)-Peroxo-Citrate Speciation. Inorg. Chem. 42, 4632-4639 (2003).

65.P. Zoumpoulakis, I. Daliani, M. Zervou, I. Kyrikou, E. Siapi, G. Lamprinidis E. Mikros, T. Mavromoustakos. Losartan’s molecular basis of interaction with membranes and AT₁ receptor. Chem. Phys. Lipids 125, 13-25 (2003).

 

66.R. Kokkinofta, P. Petrakis, T. Mavromoustakos, C.R. Theocharis. Authenticity of the traditional Cypriot spirit “Zivania” on the basis of metal content using a combination of coupled plasma spectroscopy and statistical analysis, J. Agr. Food Chem. 51(21), 6233-6239 (2003).

 

67.A.N. Batsoulis, M.K. Nacos, C.S. Pappas, P.A. Tarantilis, T. Mavromoustakos, M.G. Polissiou. Determination of uronic acids in isolated hemicelluloses from kenaf using diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) and curve-fitting deconvolution method. Applied Spectroscopy 58(2) 199-202 (2004).
 

68.I. Kyrikou_, I. Daliani, T. Mavromoustakos, H. Maswadeh, C., Demetzos_, S Xatziantoniou, S. Giatrellis, G. Nounesis. The modulation of thermal and dynamic properties of vinblastine by cholesterol in membrane bilayers BBA M BIO. 1661, 1-8 (2004).

69.K. Alexopoulos, P. Fatseas, E. Melissari, D. Vlahakos, P. Roumelioti, T. Mavromoustakos, S. Mihailescu, M. Christina, P. Carbajal, D. Mascher, J. Matsoukas. Design and Synthesis of Novel Biologically Active Thrombin Receptor Non Peptide Mimetics Based on the Pharmacophoric Cluster Phe/Arg/NH₂ of the Ser₄₂-Phe-Leu-Arg₄₆ Motif Sequence: Platelet Aggregation and Relaxant Activities J. Med. Chem. 47(13), 3338-3352 (2004).
 

70.K.S. Triantafyllidis, L. Nalbandian, P.N. Trikalitis, A.K. Ladanos, T. Mavromoustakos, C.P. Nicolaides. Structural, compositional and acidic characteristics of nanosized amorphous or partially crystalline ZSM-5 zeolite-based materials. Microporous and Mesoporous Materials 75, 89-100 (2004).

 

71.D. Kovala-Demertzi, C. Vidjeluc, M.A. Demertzis, E. Siapi, T. Mavromoustakos. The thermal effects of platinum (II) and palladium(II) complexes with 2-acetyl pyridine and pyridine-2-carbaldehyde N(4)-ethyl-thiosemicarbazones in membrane bilayers. Thermochimica Acta, 42(1-2), 53-58 (2004)

 

72.I. Kyrikou, S. Xadjikakou, D. Kovala-Demertzi, K.Viras, T. Mavromoustakos, Effects of non steroid anti-inflammatory drugs in membrane bilayers containing cholesterol. Chem. Phys. Lipids 132, 157-169 (2004).

73.I.Kyrikou, T. Mavromoustakos, S. Xatziantoniou, A. Georgopoulos, C. Demetzos. A comparative study of the effects of cholesterol and sclareol, a bioactive labdane diterpene, on phospholipids bilayers Chem. Phys. Lipids 133, 125-134 (2005).


74.E. Siapi, T. Mavromoustakos, V.Trandafir , B. Albu and P. Budrugeac. The Use of Differential Scanning Calorimetry to Study the Effects of Gentamycin on Fibrous Collageneous Membranes. Thermochimica Acta 425, 165-171 (2005).

75.J. Matsoukas, V. Apostolopoulos, H. Kallbacher, A.M. Papini, T. Tselios, K. Chatzantoni, T. Biagioli, F. Lolli, S. Deraos, P. Papathanassopoulos, T. Mavromoustakos, A. Mouzaki. Design and synthesis of a novel potent myelin basic epitope 87-99 cyclic analogue: Enhanced stability and biological properties of mimics render them a potentially new class of immunomodulators. J. Med. Chem. 48,1470-1480 (2005).
76.A. Kapou, T. Mavromoustakos, S. Nikolaropoulos, Effects of Steroidal Carriers of Alkylating Agents On DPPC Membrane Bilayers. Thermochimica Acta 429, 53-56 (2005).

77.E.T. Kefalas, P. Panagiotidis, C.P. Raptopoulou, A. Terzis, T. Mavromoustakos, A. Salifoglou. Mononuclear Titanium(IV)-Citrate Complexes from Aqueous Solutions:pH-Specific Synthesis and Structural and Spectroscopic Studies in Relevance to Aqueous Titanium(IV)-Citrate Speciation. Inorg. Chem. 44, 2596-2605 (2005).

78.Nikolas-P. Benetis, Ioanna Kyrikou, T. Mavromoustakos, Maria Zervou. Static ³¹P CP NMR Multilamellar Bilayer Broadlines in the Absence and presence of the Bioactive Dipeptide beta-Ala-Tyr or Glu" Chemical Physics 314(1-3) 57-72 (2005).

79.A. Kapou, M.A. Fousteris, S.S. Nikolaropoulos, M. Zervou, S.G. Gardadolnik, P. Zoumpoulakis, I. Kyrikou, T. Mavromoustakos. 2D NMR and conformational analysis of a prototype anti-tumor steroidal ester. J. Pharmaceut. Biomed. Anal. 38, 428-434 (2005).
80.P. Petrakis, I. Touris, M. Liouni, M. Zervou, C.R. Kokkinofta, R. Theocharis, T. Mavromoustakos. Authenticity of the traditional Cyprus spirit “Zivania” on the basis of ¹H NMR Spectroscopy Diagnostic Parameters and Statistical Analysis. P. Petrakis, I. Touris, M. Liouni, M. Zervou, C.R. Kokkinofta, R. Theocharis, T. Mavromoustakos J. Agric. Food Chem. 53(13), 5293-5303 (2005).
81.E.T. Kefalas, M. Dakanali, P. Panagiotidis, C.P. Raptopoulou, A. Terzis, T. Mavromoustakos, I. Kyrikou, N. Karligiano, A. Bino, A. Salifoglou. pH-Specific Aqueous Synthetic Chemistry in the Binary Cadmium(II)-Citrate System. Gaining Insight into Cadmium(II)-Citrate Speciation with Relevance to Cadmium Toxicity. Inorg. Chem. 44(13) 4818-4828 (2005).
82.C. Souli, N. Avlonitis, T. Calogeropoulou, G. Maksay, T. Biro, A. Tsotinis, G. Maksay, T. Biro, A. Politi, T. Mavromoustakos, A. Makriyannis, H. Reis, M. Papadopoulos. Novel 17β-substituted conformationally constrained neurosteroids that modulate GABA_A receptors. J. Med. Chem. 48(16) 5203-5214 (2005).
83.M.A.C. Preto, A.M. Hermani, L.S. Maia, T. Mavromoustakos, M. J. Ramos. Molecular Dynamics Simulations of Angiotensin II in Aqueous and Dimethylsulfoxide Environments. J. Physical Chem. Β 109, 17743-17751 (2005).
84.P. Zoumpoulakis, A. Politi, S.G. Grdadolnik, J. Matsoukas, T. Mavromoustakos. Structure elucidation and conformational study of V8. A novel synthetic non peptide AT₁ antagonist. J. Pharmaceut. Biomed. Anal.. 40(5) 1097-1104 (2006).

85.Maria K. Keramida, Theodore Tselios, Efthimia Mantzourani, Kostas Papazisis, T. Mavromoustakos_, Christian Klaussen, George Agelis, Spyros Deraos, Hamid Habibi and John Matsoukas. Design, Synthesis and Molecular Modelling of a Novel Amide Linked Cyclic GnRH Analogue Cyclo(4-9)[Lys⁴_,D-Trp⁶,Glu⁹]GnRH: Stimulation of Gonadotropin Gene Expression. J. Med. Chem. 49(1) 105-110 (2006).
86.V. Saroglou, S. Xatziantoniou, M. Smyrniotakis, I. Kyrikou, T. Mavromoustakos, A. Zompra, V. Magafa, P. Cordopatis, C. Demetzos. Synthesis, liposomal formulation and thermal effects on phospholipids bilayers of leuprolide J. Pept. Sci 12, 43-50 (2006)
87.E.D. Mantzourani, T.V. Tselios, S. Golic Grdadolnik, J.M. Matsoukas, A. Brancale, J.A. Platts, T.M. Mavromoustakos. A putative bioactive conformation for the altered peptide ligand of myelin basic protein and inhibitor of experimental autoimmune encephalomyelitis [Arg⁹¹, Ala⁹⁶] MBP_87-99. J. Mol. Graph. and Mod. 25(1),17-29, (2006).

88.T. Mavromoustakos, P. Moutevelis-Minakakis, C.G. Kokotos, P. Kontogianni, A. Politi, P. Zoumpoulakis, J. Findlay, A. Cox, A. Balmforth, A. Zoga, E. Iliodromitis. Synthesis, binding studies, and in vivo biological evaluation of novel non-peptide antihypertensive analogs. Bioorganic and Medicinal Chemistry 14, 4353-4360 (2006).

89.C. Koukoulitsa, I. Kyrikou, C. Demetzos, T. Mavromoustakos. The Role of the Anticancer Drug Vinorelbine in Lipid Bilayers Using Differential Scanning Calorimetry and Molecular Modeling. Chem. Phys. Lipids 144, 85-95 (2006).

90.E. Matzourani, T. Tselios, S. Dearos, J. Matsoukas, T. Mavromoustakos. Comparison of proposed bioactive conformations of altered peptide ligands of Myelin Basic Protein (Ala91,96) MBP87-99 and (Arg91, Ala96) MBP87-99 by Spectroscopic and Modelling studies. J. Med. Chem. 49, 6683-6691 (2006).

91.Agnes Kapou, Nikos Avlonitis, Anastasia Detsi, Maria Koufaki, Theodora Calogeropoulou, Nikolas P. Benetis, Sotirios Nikolaropoulos and Thomas Mavromoustakos, CoMFA and CoMSIA 3D-Quantitative Structure-Activity Relationships of New Flexible Antileishmanial Ether Phospholipids Bioorg. Med. Chem. 15, 1252-1265 (2007).

92.S. Durdagi, A. Kapou, T. Kourouli, T. Andreou, S.P. Nikas, V.R. Nahmias, D. P. Papahatjis, M.G. Papadopoulos, T. Mavromoustakos. The Application of 3D-QSAR Studies for Novel Cannabinoid Ligands Substituted at the C1΄ Position of the Alkyl Side Chain on the Structural Requirements for Binding to Cannabinoid Receptors CB1 and CB2. J. Med. Chem 50(12), 2875-2885 (2007).
93.S. Durdagi, M. Papadopoulos, D. Papahadjis, T. Mavromoustakos. Combined 3D QSAR and Molecular Docking Studies to Reveal Novel Cannabinoid Ligands with Optimum Binding Activity. Bioorg. Med. Chem. Lett., 17, 6754-6763 (2007).
94.Mantzourani E.D., Platts J.A., Brancale A., Mavromoustakos T.M., Tselios T.V. Molecular dynamics at the receptor level of immunodominant myelin basic protein epitope 87-99 implicated in multiple sclerosis and its antagonists altered peptide ligands: Triggering of immune response. J. Mol. Graph. Mod., 26 (2), 471-481 (2007).

95.S. Zinovia, D. Georgios, S. Georgios, E. Mantzourani, T. Mavromoustakos, I. Friligou, T. Theodore. Putative Bioactive Conformations of Amide Linked Cyclic Myelin Basic Protein Peptide Analogues Associated with Experimental Autoimmune Encephalomyelitis 50, 6039-6047 J. Med. Chem. (2007).

96.I. Kyrikou, C. Poulos, N. Benetis, K. Viras, M. Zervou, T. Mavromoustakos. Interactions of the dipeptide paralysin β-Ala-tyr and the aminoacid Glu with phospholipids bilayers. Biochim. Biophys. Acta 1778, 113-124 (2008).
97.Mantzourani, E.D., Blokar, K., Tselios, T.V., Matsoukas, J.M., Platts, J.A., Mavromoustakos, T.M., Grdadolnik S.G. A combined NMR and molecular dynamics simulation study to determine the conformational properties of agonists and antagonists against experimental autoimmune encephalomyelitis. Bioorg. Med. Chem. 16, 2171–2182, (2008).
98.P. Panagiotidis, E.T. Kefalas, C.P. Raptopoulou, A. Terzis, T. Mavromoustakos, A. Salifoglou. Delving into the complex picture of Ti(IV)-citrate speciation in aqueous media: Synthetic, structural, and electrochemical considerations in mononuclear Ti(IV) complexes containing variably deprotonated citrate ligands. Inorg. Chim. Acta 361, 2210-2224 (2008).
99.S. Durdagi, H. Reis, M.G. Papadopoulos, T. Mavromoustakos. Comparative Molecular Dynamics Simulations of the Potent Synthetic Classical Cannabinoid Ligand AMG3 in Solution and at Binding Site of the CB1 and CB2 Receptors Bioorg. Med. Chem. 16, 7377-7387 (2008).
100.C. Koukoulitsa, M. Zervou, C. Demetzos, T. Mavromoustakos. Comparative docking studies of labdane-type diterpenes with forskolin. Bioorg. Med. Chem. 16, 8237-8243 (2008).
101.A. Kapou, N.P. Benetis, S. Durdagi, S. Nikolaropoulos, T. Mavromoustakos. Synthesis and 3D QSAR/CoMFA and CoMSIA Studies on Antileukemic Steroidal Esters coupled with Conformationally Flexible Nitrogen Mustards. Journal of Chemical Information and Modeling,  48(11) 2254-2264 (2008).
102.S. Durdagi, T. Mavromoustakos, M.G. Papadopoulos. 3D QSAR CoMFA/CoMSIA, molecular docking and molecular dynamics studies of fullarene-based HIV-1 PR inhibitors, Bioorg. Med. Chem. Lett. 18, 6283-6289 (2008).

103.S. Durdagi, T. Mavromoustakos, N. Chronakis, MG Papadopoulos. Computational design of novel fullerene analogs as potential HIV 1 PR inhibitors: Analysis of the binding interactions between fullerene Inhibitors and HIV 1 PR residues using 3D QSAR, molecular docking and molecular dynamics simulations. Bioorg. Med. Chem., 16, 9957-9974  (2008).

104.C. Potamitis, M Zervou, V. Katsiaras, P Zoumpoulakis, S. Durdagi, M. Papadopoulos, J. Hayes, S. Grdadolnik, I. Kyrikou, D. Argyropoulos, G.Vatougia, T. Mavromoustakos. Antihypertensive Drug Valsartan in solution and at the AT₁ Receptor: Conformational Analysis, Dynamic NMR Spectroscopy, in silico Docking and Molecular Dynamics Simulations. J. Chem. Inf. Mod. 49, 726-739 (2009).

105.C. Fotakis, D. Christodouleas, P. Chatzigeorgiou, M. Zervou, N. P. Benetis, K. Viras, T.M. Mavromoustakos. Application of a novel CP-³¹P NMR methodology to study the possible interdigitation effect of losartan in phospholipids bilayers. Comparison with Raman spectroscopy data Biophys. J. 96, 2227-2236 (2009).

106.C. Koukoulitsa, A.T. Kakoulidou, T. Mavromoustakos, I. Chinou. PLS Analysis for Antibacterial Activity of Natural Coumarins Using VolSurf Descriptors. QSAR Comb. Sci. 28,785-789 (2009).
107.Kotzabasakis, V., Kostakis, K., Pitsikalis, M., Hadjichristidis, N., L.D., David, Mavromoustakos, T., Potamitis, C. Polymerization of Higher α-Olefins Using a Cs-Symmetry Hafnium Metallocene Catalyst. Kinetics of the Polymerization and Microstructural Analysis. J. Polym. Sci. Part A 47, 4314-4325 (2009).
108.Durdagi S., Supuran, T., Amalda, T.S, Doostdar, N., Kumar, M.K., Barron, A.R., Mavromoustakos, T., Papadopoulos, M.G. In Silico Drug Screening Approach for the Design of Magic Bullets: A Successful Example with Anti-HIV Fullerene Derivatized Amino Acids. J. Chem. Inf. Model. 49, 1139-1143 (2009).
109.Aggeliki Politi, Serdar Durdagi, Panagiota Moutevelis-Minakakis, George Kokotos, Manthos G. Papadopoulos, Thomas Mavromoustakos. Application of 3D QSAR CoMFA/CoMSIA and in silico docking studies on novel renin inhibitors against cardiovascular diseases. Eur. J. Med. Chem. 44(9) 3703-3711 (2009).
110.L.Mannina, M.D. Imperio, D. Capitani, S. Rezzi, C. Guillou, T. Mavromoustakos, M.D. Vilchez, A.H. Fernandez. ¹H NMR-Based Protocol for the Detection of Adulterations of Refined Olive Oil with Refined Hazelnut Oil. J. Agr. Food Chem. 57(24) 11550-11556 (2009).

111.C. Fotakis, S. Gega, E. Siapi, C. Potamitis, K. Viras, P. Moutevelis-Minakakis, G. Kokotos, S. Durdagi, S. Grdadolnik, B. Sartori,M.Rappolt, T. Mavromoustakos. Drug interactions at the bilayer interface and receptor site induced by the novel synthetic pyrrolidinone analog MMK3. Biochim. Biophys. Acta 1798(3) 422-432 (2010).

112.V.D. Mouchlis, T.M. Mavromoustakos, G. Kokotos. Design of new secreted phospholipase A₂ inhibitors based on docking calculations by modifying the pharmacophore segments of the FPL67047XX inhibitor. J. Comput. Aided. Mol. Des. 24(2) 107-115 (2010).
113.S. Durdagi, M. Papadopoulos, P. Zoumpoulakis, C. Koukoulitsa; T. Mavromoustakos. A Computational Study on Cannabinoid receptors and Potent Bioactive Cannabinoid Ligands: Homology Modeling, Docking De novo Drug Design and Molecular Dynamics Analysis. Molecular Diversity 14(2) 257-276 (2010).
114.A. P. Politi, M. V. Zervou, H. Triantafyllidi, P. G. Zoumpoulakis, T. M. Mavromoustakos, A. A. Zoga, P. Moutevelis-Minakakis, G. Kokotos, E. K. Iliodromitis, D. Th. Kremastinos, Hypertension study in anesthetized rabbits: Protocol proposal for AT1 antagonist screening” Journal of the Renin-Angiotensin-Aldosterone System, 11(2) 103-110 (2010).
115.P. Roumelioti, A. Resvani, S. Durdagi, M.Eleni, K. Kelaidonis, T. Mavromoustakos, G. Aggelis, J. Matsoukas. An efficient synthesis of a rationally design 1,5 disubstituted imidazole AT1 Angiotensin Receptor Antagonist. Reorientation of imidazole pharmacophore groups in losartan reserves high receptor affinity and confirms docking studies. J. Comput. Aided. Mol. Des. 24 749-758 (2010).
116.V. Mouchlis, T. Mavromoustakos, G. Kokotos. Molecular Docking and 3D-QSAR CoMFA Studies on Indole Inhibitors of GIIA Secreted Phospholipase A2. J. Chem. Inf. Mod. 50, 1589-1601 (2010).
117.A.P. Politi, S. Durdagi, P.M. Minakakis, T. Mavromoustakos, G. Kokotos. Development of Accurate Binding Affinity Predictions of Novel Renin Inhibitors through Molecular Docking Studies. J. Mol. Gr. Mod. 29 425-435 (2010).

118.V.Mouchlis, V. Magrioti, E.Barbayianni, N. Cermak, R. C. Oslund, T. Mavromoustakos, M. H. Gelb, G. Kokotos. Inhibition of secreted phospholipases A2 by 2-oxoamides based on α-amino acids: Synthesis, in vitro evaluation and molecular docking calculations. Bioorg. Med. Chem. 19, 735-743 (2011).

119.T. Mavromoustakos, P. Chatzigeorgiou, C. Koukoulitsa, S. Durdagi. Partial Interdigitation of Lipid Bilayers. International Journal of Quantum Chemistry 6, 1172-1183 (2011).
120.C. Potamitis, P. Chatzigeorgiou, E. Siapi, T. Mavromoustakos, A. Hodzic, F. Cacho-Nerin, P. Laggner, M. Rappolt. Interactions of the AT₁ antagonist valsartan with dipalmitoyl-phosphatidylcholine bilayers Biochim. Biophys. Acta 1808, 1753-1763 (2011).
121.Panagiota Moutevelis-Minakakis, Eleni Papavassilopoulou, George Michas, Kalliopi Georgikopoulou, Maria-Eleni Ragoussi, Panagiotis Zoumpoulakis, Thomas Mavromoustakos, Dimitra Hadjipavlou-Litina. Synthesis, in silico docking experiments of new 2-pyrrolidinone derivatives and study of their anti-inflammatory activity Bioorg. Med. Chem. 19, 2888-2902 (2011).
122.N. Neophytou, G. Leonis, N. Stavrinoudakis, M. Simcic, S.G. Grdadolnik, G. Michas, P. Minakaki, E. Papavassiliou, M. Papadopoulos, M. Zheng, S. Grdadolnik, M, Simcic, T. Mavromoustakos. Docking and Molecular Dynamics calculations of pyrrolidinone analog MMK16 bound to COX and LOX enzymes Mol. Inf. 30, 473-486 (2011).
123.Charalambos Fotakis, Dionyssios Christodouleas, P. Zoumpoulakis, Argyro Gili, E. Kritsi, Nikolas-Ploutarch Benetis, Maria Zervou, Heribert Reis, Manthos Papadopoulos, Thomas Mavromoustakos. Comparative Biophysical studies of sartan class drug molecules losartan and candesartan (CV-11974) with membrane bilayers J. Chem. Phys. B 115, 6180-6192 (2011).
124.Koukoulitsa C., Durdagi S., Siapi E., Villalonga-Barber C., Xanthippi A., Barry R. S., Micha-Screttas M., Michael N. Alexis, Anna Kakoulidou, Mavromoustakos T. Comparison of thermal effects of stilbenoid analogs in lipid bilayers using differential scanning calorimetry and molecular dynamics: correlation of thermal effects and topographical position with antioxidant activity. Eur. Biophys. J. 40, 865-875 (2011).
125.M. Poyraza, C. Bantia, N. Kourkoumelis, V. Dokoroud, M.J. Manose, M. Simčič, S. Golič Grdadolnik, T. Mavromoustakos, I.I. Verginadis, K. Charalabopoulos, S.K. Hadjikakou. Synthesis, structural characterization and biological studies of novel mixed ligand Ag(I) complexes with tri-phenylphosphine and aspirin or salicylic acid Inorg. Chim. Acta 375, 114-121 (2011).
126.C. Potamitis, M. Matsoukas, T. Tselios, T. Mavromoustakos, S. Golic Grdadolnik. Conformational Analysis of [Phe⁹¹]ΜΒΡ_83-99 and [Tyr⁹¹]ΜΒΡ_83-99 peptide analogues and study of their interactions with HLA-DR2 receptor and human TCR receptors using Molecular Dynamics 25, 837-853 J. Comput. Aided Mol. Des (2011).
127.Dimitrios Ntountaniotis, Gregor Mali, Simona Golic Grdadolnik, Halabalaki Maria, Alexios-Leandros Skaltsounis, Constantinos Potamitis, Eleni Siapi, Petros Chatzigeorgiou, Michael Rappolt, Thomas Mavromoustakos. Thermal, dynamic and structural properties of drug AT₁ antagonist olmesartan in lipid bilayers Biochim. Biophys. Acta 1808, 2995-3006 (2011).