Thomas mavromoustakos



Yüklə 419 Kb.
səhifə1/5
tarix19.07.2018
ölçüsü419 Kb.
#56647
  1   2   3   4   5

THOMAS MAVROMOUSTAKOS

Capodistrian University of Athens

Professor of Chemistry Department
Date of birth: 18/6/1960

Address: National Capodistrian University of Athens, Chemistry Department, Panepistimiopolis Zographou 15771 and National Hellenic Research Foundation

Tel: +30 2107274475 and +30 2107273869

FAX: +30 2107274761 and +30 2107273868

e-mail: tmavrom@chem.uoa.gr and tmavro@eie.gr

Family status: Married with four children


EDUCATION
B.Sc. 1985 Chemistry, University of Athens, Greece.
M.Sc. 1988 Medicinal Chemistry, University of Connecticut
Ph.D. 1990, Medicinal Chemistry, University of Connecticut.
B.Sc. 2007 Theology School, University of Athens, Greece.
M.Sc. 2012 Social Theology School, University of Athens, Greece

Doctoral Dissertation: Study of the cannabinoid and anesthetic steroids with artificial and biological membranes. The dissertation can be found in the web site: http://phdtheses.ekt.gr/eadd/handle/10442/12696
EMPLOYMENT
1985-1987. Teaching Assistant in School of Pharmacy for introductory and advanced level courses.
1988-October 1990. Research Assistant in School of Pharmacy.
October 1990-June 1991. Postdoctoral Fellow in School of Pharmacy.
June 1991-September 2004. Researcher director at Laboratory of Molecular Analysis (LMA) at the Institute of Organic and Pharmaceutical Chemistry (IOPC) of National Hellenic Research Foundation (NHRF). Use Molecular Modeling to study the conformational analysis of antihypertensive drugs, cannabinoids,steroids. and other bioactive molecules. Perform NMR experiments both in solution and in solid state to study the conformation analysis of biologically active molecules and drug:membranes interactions. Use DSC as a complementary tool to study the thermal changes in membrane bilayers after the incorporation of drugs. Use the modern high technology infrastructure of the institute to collaborate and solve some of the research problems facing professors at Greek Universities. Such problems include structure determination of zeolithes, inorganic complexes and soil materials.
September 2004-beginning of January 2005. Visiting associate professor at the University of Cyprus (Chemistry Department). Teaching of Organic Chemistry laboratory and Medicinal Chemistry.

January 2005-2007 Director of Laboratory of Molecular Analysis (LMA) at IOPC.
2007- Elected since 2007 a President of the new established Center of Applied Research and Technology of Nicosia, Cyprus.
January of 2007-May of 2007. Visiting associate professor at the University of Cyprus (Chemistry Department). Teaching of Organic Chemistry laboratory and Medicinal Chemistry.
September 2007-2012. Associate Professor at the Chemistry Department of Athens
June 2012- Full Professor at the Chemistry Department of Athens

AWARDS
1. Fellowship sponsored by Royal Society for two monthly stayment in Great Britain. During my residence at the University of York I was trained in Molecular Graphics at Prof. Rod Hubbard's laboratory.
2. Award for the 3rd best presented poster in the Third International Conference on Applications of Magnetic Resonance in Food Science, Nantes, September 16-18, 1996.
3. Award by the Academy of Athens (29 December 1998) for the best research activity in 1998 related to hypertension.
4. Award of a Fulbright Scholarship for the Summer of 1999.
5. Award for the 3rd best presented poster in the Conference of Patras entitled Medicinal Chemistry Design and Development of Drugs in Medicinal Chemistry (1-3, 2001).
6. Award for the 3rd best presented poster in the Conference of Patras entitled Medicinal Chemistry Design and Development of Drugs in Medicinal Chemistry (7-9, 2002).
7.In October of 2000, a committee consisting of Prof. E.C. Constable, Prof. G.W. Gray, Prof. M.W. Gray, Prof. P.A. Schubiger και Dr. N. Ragousi, characterized the research activity of Medicinal Chemistry as an excellent (“the work done in this group is excellent”) and also the research referred to the adulteration of olive oil (“the work of the group on virgin olive oil adulteration is worthy of note”). LMA is involved in both activities.
8. Reference of my research activity on peptidomimetism by the company Synergix Ltd in the software of «Molecular Conceptor”. A chapter is written on the synthesis of Bioactive Molecules with G. Cohen of the same company and the product is now commercially available.
9.Scholarship by Royal society and COST D22 to perform binding experiments of antihypertensive molecules in AT1 and AT2 receptors as well as cell cultures.
10.Selected to teach at the University of Cyprus courses of Organic and Medicinal Chemistry.
11.The article “Conformation and Bioactivity, Design and Development of Novel Antihypertensive Molecules is publishe in the Journal of “Current and Medicinal Chemistry (IF 4.483) and was selected one of the best articles. This article after being modified was published in the “Frontiers in Medicinal Chemistry (volume 2).
12.Invitation by Prof. A.M. Dopico to write a chapter in the book “Methods in Membrane Lipids” by Humana Press. The book has been circulated in 2007 and the chapter I have written appears with no 39 entitled “The Use of Differential Scanning Calorimetry to Study Drug-Membrane Interactions”.
13.Honored as a second degree Universal Title in Theology (3.2.2008).
14.Selected as evaluator from the Scientific Committee of National Programs of Slovenia during the phases A and B (2007 until now).
15.In Wikipedia there is a web site referred to AMG-3 cannabinoid in which the following publications are mentioned: Mavromoustakos T, Theodoropoulou E, Zervou M, Kourouli T, Papahatjis D. Structure elucidation and conformational properties of synthetic cannabinoids (-)-2-(6a,7,10,10a-tetrahydro-6,6,9-trimethyl-1-hydroxy-6H-dibenzo[b,d]pyranyl)-2-hexyl-1,3-dithiolane and its methylated analog. Journal of Pharmaceutical and Biomedical Analysis. 1999 Jan;18(6):947-56. PMID 9925329 and Durdagi S, Papadopoulos MG, Papahatjis DP, Mavromoustakos T. Combined 3D QSAR and molecular docking studies to reveal novel cannabinoid ligands with optimum binding activity. Bioorganic and Medicinal Chemistry Letters. 2007 Dec 15;17(24):6754-63. PMID 17980589

16. In htpp://www.newsrx.com/article (NewsRX. Medical News article on Medicinal Chemistry, 16.7.2007) is mentioned the article S. Durdagi et al J. Med. Chem. 50, 2875-2885 (2007).

17 The article by S. Durdagi et al J. Chem. Inf. Model. 49,1139-1143 (2009) is mentioned in the http://www.rice.edu/nationalmedia/news2009-05-19-hiv.shtml

18. In Science Daily in the Science news it is published the article entitled “Buckyball Computer Simulations Help Team Find Molecular Key to Combating HIV of the article by S. Durdagi et al J. Chem. Inf. Model. 49,1139-1143(2009) http://www.sciencedaily.com/releases/2009/05/090519134839.htm.

19. In the Genetic Engineering & Biotechnology News is mentioned the published article by S. Durdagi et al J. Chem. Inf. Model. 49,1139-1143(2009) http://www.genengnews.com/news/bnitem.aspx?name=54814928&taxid=3

20. It is mentioned in the Blog der Gesundheit. Eine gute Gesundheit ist das wichtigste für den Körper und vor allem für ihren Geist. Achten sie auf diesen!


the article of S. Durdagi et al J. Chem. Inf. Model. 49,1139-1143(2009) http://gesundheit-blog.weiterlesen.net/new-found-molekule-mai-block-hiv-spread.html

21. The article Combined 3D QSAR and molecular docking studies to reveal novel cannabinoid ligands with optimum binding activity published in


Bioorganic & Medicinal Chemistry Letters, Volume 17, Issue 24, December 2007, Pages 6754-6763 by Durdagi, S.; Papadopoulos, M.G.; Papahatjis, D.P.; Mavromoustakos, T. was selected on the top 25 between October-December of 2007 http://top25.sciencedirect.com/subject/chemistry/6/journal/bioorganic- medicinal-chemistry-letters/0960894X/archive/14&print=true

22. The article Development of Accurate Binding Affinity Predictions of Novel Renin Inhibitors through Molecular Docking Studies. J. Mol. Gr. Mod. 29 425-435 (2010) by A.P. Politi, S. Durdagi, P.M. Minakakis, T. Mavromoustakos, G. Kokotos was elected by the journal as one of the 25 best articles between October-December 2010. http://top25.sciencedirect.com/subject/pharmacology-toxicology-and-pharmaceutical-science/20/journal/journal-of-molecular-graphics-and-modelling/10933263/archive/30



Brief Description of My Research Activities



  • Design of novel drugs against various diseases (i.e hypertension and inflammation)

To achieve this aim I use the following physical chemical methodologies:

a. Solid State Nuclear Magnetic Resonance in order to study the dynamic changes it causes the antihypertensive drug in the lipid bilayers. In addition, the orientation of drugs in lipid bilayers is sought using deuterium NMR in collaboration with synthetic chemists who deuterate specific sites of drugs.

b. High Resolution Nuclear Magnetic Resonance in duterated solvents or environments that simulate the active site of action.

c. Conformational Analysis Using NMR ROE data in combination with computational analysis and molecular modeling to complement the experimental results.

d. Differential Scanning Calorimetry to study the thermal changes that causes the presence of pharmaceutical compounds with model membranes.

e. X-ray diffraction where the topography of drugs is sought in lipid bilayers. The X-ray diffraction experiments are run in Graz of Austria under the guidance of Prof. P. Laggner.

f. Raman Spectroscopy to study the interactions of bioactive compounds with lipid bilayers. In particular, the trans:gauche ratio is estimated at the different mesomorphic states of lipid bilayers.

g. 3D-QSAR studies. CoMFA and CoMSIA softwares are applied to reveal the stereoelectronic requirements for a drug to exert biological activity. 3D-QSAR studies is a valuable tool in the rational design.

h. Simulation of NMR spectra in liquid and solid state with the collaboration of theoretical physical chemists.

k. Docking studies of antihypertensive drugs with AT1 receptor.

l. Searching for pharmacophore models in bioactive drug molecules.




  • Authenticity aspects of beverages and foods

a. Study of geographical origin and adulteration of virgin olive oil by other cheaper oils using high resolution 13C-NMR of olefinic region. In addition it is studied the adulteration of refined oil by refined hazelnut oil.



b. Study of authenticity of Cypriot beverage zivania with the combination of different physical chemical methods in collaboration with the University of Cyprus ( 1Η-NMR and Raman Spectroscopies, ICP, Gas Chromatography, Refractometry, Statistical Analysis to facilitate the analysis of the output data etc).

Yüklə 419 Kb.

Dostları ilə paylaş:
  1   2   3   4   5




Verilənlər bazası müəlliflik hüququ ilə müdafiə olunur ©www.genderi.org 2024
rəhbərliyinə müraciət

    Ana səhifə