Computational Molecular Docking Models and Design of Diarylpentanoids for the Androgen Receptor

 
 

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VII 
TABLE OF CONTENTS 
 
 
Page 
DEDICATION ................................................................................................................ IV
ACKNOWLEDGEMENTS ........................................................................................... IV
ABSTRACT ...................................................................................................................... V
LIST OF TABLES .......................................................................................................... IX
LIST OF FIGURES .......................................................................................................... X
LIST OF ABBREVIATIONS ....................................................................................... XII
1
INTRODUCTION ....................................................................................................... 1
2
PREVIOUS STUDIES AND REVIEW OF LITERATURE ................................... 3
2.1
ca27 and the Androgen Receptor ......................................................................... 3
2.2
Computational Modeling of Curcumin and the AR ............................................. 6
2.3
Previous MolSoft ICM Results from Undergraduate Senior Capstone ................ 7
2.4
Pains Molecules and their Significance .............................................................. 13
2.5
Flexibility in the DBD and LBD ........................................................................ 14
3
HYPOTHESIS ........................................................................................................... 16
4
SPECIFIC AIMS ....................................................................................................... 17