Biotop-report 2013



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35

BioTOPics 46 | September 2013 

BioTOP-Report

 Life Sciences 

stitute for Agricultural Engineering (ATB) in Potsdam-Bornim 

whose research focuses on resource-efficient and carbon-neutral 

use of biological systems for the production of foods, raw materi-

als and energy, and the Fraunhofer Institute for Applied Polymer 

Research (IAP) in Potsdam-Golm, which is a leading provider in 

the field of applied cellulose and starch research and opened a 

competence centre for biopolymer processing at the BASF site 

Schwarzheide in April 2013 (see on page 23). 

As part of a nationwide programme of the German Federal Min-

istry of Education and Research (BMBF), new concepts for future 

biotechnology have been developed jointly with research organi-

sations and universities since 2010 to provide the foundation for 

the development of a bio-based economy. To see which projects 

in Berlin-Brandenburg are involved in this programme, please 

turn to page 41. 

Certified excellence 

In addition to Freie Universität Berlin, the Humboldt Universität 

zu Berlin also succeeded with its concept for future development 

in the context of the Excellence Initiative for cutting-edge re-

search at institutions of higher education. One of the university’s 

main goals thus is the continued development of its Integrative 

Research Institute (IRI) for the Life Sciences (see on page 36). 

Other life sciences projects and initiatives in Berlin-Brandenburg 

funded under the Excellence Initiative include the Berlin-Bran-

denburg School for Regenerative Therapies BSRT (a graduate 

school in the field of Regenerative Medicine), NeuroCure (a Clus-

ter of Excellence focused on the neurosciences) and UniCat (the 

Cluster of Excellence “Unifying Concepts in Catalysis”).

You will find more detailed information on these Excellence Initia-

tives and an overview of other research projects involving scien-

tists from Berlin and Brandenburg in our publication BioTOPics 45 

“Life Sciences from A to Z”.



NOVEMBER 2012

Federal and state governments agree to found the Berlin Institute of Health 

(BIH). It is created from the merging of Charité and Max Delbrück Center for 

Molecular Medicine. In the future, scientists conducting basic research and 

clinical research will thus work hand in hand.

DECEMBER 2012

Christian Hackenberger receives Leibniz Humboldt professorship for chemi-

cal biology 

++++ 


Performance of German Institute of Human Nutrition (DifE) 

rated as very good to excellent 

++++ 

MDC celebrates 20th anniversary. 



JANUARY 2013

Charité and FU are jointly successful in the competition "EXIST-Gründung-

skultur – Die Gründerhochschule" of the German Federal Ministry of Econom-

ics and Technology 

++++ 

German Research Foundation extends collabora-



tive research centre (SBF 650) at Charité – ten million Euros for research on 

immunological therapy



FEBRUARY 2013

Humboldt research award gets Ivy-League professor Klaas van Wijk to Pots-

dam 

++++ 


Biopolymers – strong future field with high potential for innova-

tion presents itself in Schorfheide



MARCH 2013

Hasso-Plattner-Institut speeds up personalised medicine with new data bank 

technology 

++++ 


Integrative Research Institute for Life Sciences (IRI) found-

ed in Berlin 

++++ 

Paul Ehrlich- and Ludwig Darmstaedter Prize goes to MDC 



scientist Dr. James Poulet

APRIL 2013

Charité and Sorbonne found Virchow-Villermé Centre for Public Health 

++++ 

EU-OPENSCREEN included in the new BMBF-roadmap for large research 



infrastructures

MAY 2013

New laboratory building of MDC opened – named after physiologist Max 

Rubner 

++++ 


Stem cell researchers in Germany pool their expertise. They 

found the German Stem Cell Network (GSCN) on May 7

th

 2013 


++++ 

Evalu-


ators praise Berlin Institute of Health (BIH). Enst Theodor Rietschel becomes 

chairman


JUN 13

BIH officially opened 

++++ 

Charité – Universitätsmedizin Berlin once more 



reaches rank 1 of Focus-ranking "Germany's best hospital"


36

BioTOPics 46 | September 2013 

BioTOP-Report

 Life Sciences 

Know-how in Systems Medicine and 

Systems Biology 

In the past years, it has become evident that determining the function of singular genes is insufficient for 

understanding the processes in our body and the development of diseases. Therefore, biomedical research 

increasingly follows a holistic approach. The new key words in this context are “systems biology” and “systems 

medicine”. Researchers use highly modern techniques to gain precise insight into the molecular networks of 

genes and their products, the proteins, as well as their regulation and interaction, to understand their impor-

tance in the development of diseases. The resulting vast quantity of data is evaluated with help of mathematics

informatics, and powerful computers. In the German capital region, significant know-how has been built and 

structures have been created for this.

Amongst the internationally prominent names of Berlin med-

icine in this context are the Max Delbrück Center for Molecu-

lar Medicine (MDC) – it focuses on basic research and is part of 

the Helmholtz Association – and in clinical research the Charité 

- Universitätsmedizin Berlin. MDC and Charité now combine their 

research in the newly founded Berlin Institute of Health (BIH). It 

will be set up with public funds of 300 million Euros until 2018. 

Additionally, 40 million Euros come from the benefactor Johanna 

Quandt. The BIH follows a holistic, systems medical approach for 

the first time in Germany. That means steering away from single 

organs or disease patterns towards the overarching mechanisms 

causing diseases. In doing so, systems medicine uses genetic

cell biological, biochemical, and physiological methods, imaging 

techniques, and extensive technology platforms. The aim is the 

medical translation, meaning the development of new diagnostic 

techniques, therapies, and preventive measures to increase and 

speed up the transfer of research findings to hospitals.

Humboldt Universität (HU) is also invested in interdisciplinary 

life sciences research. The Integrative Research Institute (IRI) for 

Life Sciences, funded by the Excellence Initiative of federal and 

state governments, is a core project of the university’s plans for 

the future, having gained the status of elite university in 2012. 

The scientific areas involved in the project range cover the entire-

ty of life, from the molecular level to the complex organism. The 

research focus of the IRI lies on the areas of commitment of the 

institutions supporting it: Systems biology and theoretical biolo-

gy (represented by centres of HU, Charité, and MDC); Neurosci-

ences (represented by the Bernstein Center Berlin, an excellence 

cluster and a graduate school of HU) as well as infection biology 

and immunology (represented by the Center for Infection Biology 

and Immunity of HU). From these areas of focus, the IRI wants to 

strengthen the connection between theoretical and experimen-

tal techniques as well as clinical application areas. The everyday 

life in hospitals is set to profit especially from research insights 

into neurological diseases (nervous system, strokes), oncological 

diseases, and regenerative medicine. An important part of the IRI 

will be the Berlin Institute for Medical Systems Biology (BIMSB) 

of the MDC, which is a pioneer of systems biology in Germany. 

Founded 2008, it focuses on the research of post-transcriptional 

regulation of the genome and its influence on cancer, cardiac, 

metabolic, and neurologic diseases. 

Prof. Ernst Rietschel

CEO · Berlin Institute of Health – BIH

With the establishment of the Berlin Institute of Health (BIH), 

the German federal government and the federal  state of Ber-

lin want to respond to proposals from the academic sector to 

promote translational research, i.e. the transfer of research 

results into clinical practice and back. In the new institute, the 

MDC and Charité will combine their basic and clinical research. 

In this endeavour, systems medicine plays an essential con-

ceptual role representing a unique selling point of the BIH.




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