Us 6,743,786 Vanadium Compounds for Treating Cancer Chrissy Brown (PO)

US 6,743,786 Vanadium Compounds for Treating Cancer

• Chrissy Brown (PO)

• Lisa Perlson (AI)

• November 15, 2006

Claimed Invention: VCp2(bpy)OTf2

Anticancer Activity of VCp2Cl2

Monodentate v. Bidentate VCp2 Ligands

Anticancer Activity of VCp2(bpy)

Claimed Invention: VCp2(bpy)OTf2

Claimed Invention: VCp2(bpy)OTf2

Synthesis of VCp2(bpy)OTf2

• 2 step synthesis of TiCp2(bpy)OTf2 published in 1986

• (J. Organometallic Chem. 1986, 302, 193.)

• Patent acknowledges using “modified” TiCp2(bpy)(OTf2)2 synthesis

• VCp2X2 and TiCp2X2 are commonly made using the same procedure, as would be known by POSITA.

• VCp2Cl2 and TiCp2Cl2 are commercially available.