PET imaging is limited by the access to tracer production unit (cyclotron) Rubidium-82 can easily be produced by a Strontium-82 generator, without the need of cyclotron
Rb-82 is an analog of K+ (potassium). Rb-82 is an analog of K+ (potassium). Strontium-82 ( half-life 25.5 days) decays to Rubidium-82 (half-life 75 sec, positron emission, annihilation photons 511kev). As Thallium (Tl-201) Rb-82 is extracted by myocardial tissue via the Na⁺K+-ATPase active transport. The short half-life of Rubidium-82 allows to perform rest/stress imaging within 20 minutes. We use an adenosine stress (140 µg/kg/min over 6 min) to perform real time stress imaging owing to the short half-life of Rb-82 .
New generator every month. New generator every month. Possible elution every 10min. The radionucleidic purity of Rb-82 eluate is determined by measuring the residual activity of Sr-82 and Sr-85 using a ionization chamber. Any other radionucleidic in the elution is considered a radionucleidic impurity . The final eluate should not contain more than 0.02 kBq of Sr-82 and not more than 0.2 kBq of Sr-85 per MBq of Rb-82 injection.
Shorter acquisition time Lower radiation exposure Attenuation correction Ejection Fraction at peak stress
To assess the evolution of Sr-82 and Sr-85 breakthrough during the clinical use of Rb-82 generator . To assess the evolution of Sr-82 and Sr-85 breakthrough during the clinical use of Rb-82 generator .
10 generators Cardiogen-82 ® Bracco Diagnostics of Rb-82 were used for 481 rest/stress studies. 10 generators Cardiogen-82 ® Bracco Diagnostics of Rb-82 were used for 481 rest/stress studies. 162 radionucleidic purity controls were performed before any injection to the first patient. Sr-82/Rb-82<0.02 kBq/MBq Sr-85/Rb-82<0.2 kBq/MBq
BEFORE ANY INJECTION TO THE FIRST PATIENT
The high peaks may be explained by : The high peaks may be explained by : - Intrinsic variations of the activimeter
- Breakthrough variations in the laboratory
- Number of days since last use (accumulation of Sr-82 during the week-end)
Sr-82 and Sr-85 breakthroughs were small for a total eluted volume <8L Every controls remained under the authorized limits and allowed the clinical use of Rb-82
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