Multiscale Modeling of Brain Dynamics Peter Robinson



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Multiscale Modeling of Brain Dynamics

  • Peter Robinson

  • School of Physics, University of Sydney

  • Brain Dynamics Center, Westmead Hospital

  • & University of Sydney

  • Faculty of Medicine, University of Sydney

  • Supported by the ARC and NHMRC.


Kevin Aquino Homi Bahramali Matt Barton Lindsay Botha Paul Bourke Michael Breakspear Parry Chen Po-Chia Chen Alan Chiang Jonathon Clearwater Nick Cooper Tim Cooper Peter Drysdale Ben Fulcher Candy Fung Biljana Germanoska Evian Gordon Stuart Grieve Ron Grunstein





Measurement: what, why, how?



Integration





Modeling



Neurons



Synapses and Dendrites







The Model





Coherence, Time Series, Stability



Brain Resource International Database

  • Brain Resource Ltd.

  • Spinoff 2001, ASX listed.

  • Approx. $40M market cap.

  • Database of circa 30 000 subjects, aged 6-80+.

  • Approx. 50 functional measures per subject + MRI.

  • Excellent statistics.

  • Customers and labs in circa 10 countries.

  • 1st fully standardized international brain function database.

  • Access via BRAINnet.



Inversion



Absence Seizures

  • Linear instability at 3 Hz.

  • Ramping se up and down yields start and end of ‘spike and wave’ oscillations via supercritical Hopf bifurcation.



Ocular Dominance and Orientation Preference



Gamma Oscillations, Binding



Gamma Resonances from Patchy Propagators





Scene Segmentation



Arousal Dynamics

  • How does the brain move between arousal states?

  • Develop and apply a quantitative, physiologically-based model of arousal dynamics, with parameters from experiment.

  • Brainstem ascending arousal system must be integrated, plus circadian oscillations.

  • Physiological Modeling and Parameter Constraints



Model Dynamics



Orexin, Narcolepsy, and Modafinil







Summary





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