C U R R I C U L U M V I T A E
Anahit Ghochikyan, Ph.D
Personal Data:
Address
16371 Gothard St. Suite H,
Huntington Beach, CA 92647
Tel: (714)-596-3981
FAX: (714)-596-3791
Education:
1984
M.S., Biochemistry and Genetics
Yerevan State University, Armenia
1998
Ph.D., Molecular Biology, Institute of Biochemistry of the Academy
of Sciences of Armenia.
Ph.D. thesis " Molecular organization and expression of argBJ and
ama genes of B.stearothermophilus". Supervisor Prof. Vehary
Sakanyan.
Employment:
2000-present Institute for Molecular Medicine, Huntington Beach, CA
Research Assistant Professor at the Department of Immunology.
Development of an effective and safe vaccine against Alzheimer’s
Disease. Generation of BORIS-based anti-cancer vaccine in 4T1 breast
cancer mouse model. Analyses of immunosuppressor cells, anti-cancer
immune responses in vaccinated mice, dissemination of metastases into
the distant organs.
1999-2000
University of Nantes, France.
Postdoctoral Scientist in Faculty of Science, Laboratory of Biocatalyse
1998-1999
Research Institute of Biotechnology, Armenia
Postdoctoral Scientist in Laboratory of Gene Engineering.
1996-1997
Weizmann Institute of Science, Israel
Department of Structural Biology. Visiting graduate student.
1993-1996
Research Institute of Biotechnology, Armenia.
Graduate student in Laboratory of Gene Engineering
Study of molecular organization of arginine biosynthesis genes and
aminoacylase gene of thermophilic bacterium B. stearothermophilus.
1984-1993
Research Institute of Biotechnology, Armenia.
Research Technician in laboratory of Gene Engineering.
Construction of strains producing arginine and aminoacylase.
Patents:
1. Mett I.L., Kochikyan A.V., Mett A.L., Sakanyan V.A. (1985). Authorship certificate
#1374782.
2. Sakanyan V.A., Kochikyan A.V., Mett I.L., Chagchalyan A., Ter-Karapetyan V.G.,
Hovsepyan A.S. (1986). Authorship certificate # 1405312.
3. Mett I.L., Mett A.L., Kochikyan A.V., Sakanyan V.A., Ivanov A.S. (1987). Authorship
certificate # 1510360.
4. Mett I.L., Mett A.L. Kochikyan A.V., Sakanyan V.A. (1989) Authorship certificate
# 1639063
5. Sakanyan V., Snapyan M., Ghochikyan A., Lecocq M. (2001).
Improved methods of RNA and protein synthesis. EP 01402049.9, deposition 27.07.2001.
6. Sakanyan V., Snapyan M., Ghochikyan A., Lecocq M., Guevel L., Weigel P.,
Braun F. (2001) Protein arrays, methods for their preparation and methods for the
detection of intermolecular interactions. EP 01402050.7, deposition 27.07.2001.
7. Ghochikyan A., Agadjanyan M.G. Preventive cancer vaccine based on brother of
regulator of imprinted sites molecule (BORIS). Application No. AU 2004268001 B2.
Priority date 2003.08.25.
8. Ghochikyan A., Agadjanyan M.G. Preventive cancer vaccine based on brother of
regulator of imprinted sites molecule (BORIS). CA 2537161 A1 2005/03/10. Priority date
2003.08.25.
9. Ghochikyan A., Agadjanyan M.G. Preventive cancer vaccine based on brother of
regulator of imprinted sites molecule (BORIS). CN000001871025B. Priority date
2003.08.25.
10. Ghochikyan A., Agadjanyan M.G. Preventive cancer vaccine based on brother of
regulator of imprinted sites molecule (BORIS). US 8114405 B2. Priority date
2003.08.25.
11. Ghochikyan A., Agadjanyan M.G. Preventive cancer vaccine based on brother of
regulator of imprinted sites molecule (BORIS). US 7579452B2. Priority date
2003.08.25.
12. Ghochikyan A., Agadjanyan M.G. Preventive cancer vaccine based on brother of
regulator of imprinted sites molecule (BORIS). EU No. 1667711 (in Germany, Austria,
Switzerland/Liechtenstein, Denmark, Italy, Netherlands). Priority date 2003.08.25.
13. Ghochikyan A., Agadjanyan M.G. Preventive cancer vaccine based on brother of
regulator of imprinted sites molecule (BORIS). Патент на Изобретение РФ, No
2385163. Priority date 2003.08.25.
14. Ghochikyan A., Agadjanyan M.G. Preventive cancer vaccine based on brother of
regulator of imprinted sites molecule (BORIS). India, 312/MUMNP/2006 A.
Priority date 2003.08.25
15. Ghochikyan A., Agadjanyan M.G. Anti-Tau antibodies and compositions for and
methods of making and using in treatment, diagnosis and monitoring of tauopathies.
US 2014/0056901 A1
16. Ghochikyan A., Agadjanyan M.G. Compositions and methods related to diseases
associated with deposits of amyloid, Tau, and α-synuclein. WO 2014/031697 A3
17. Ghochikyan A., Ataullakhanov R., Agadjanyan M.G., Pichugin A., Bagaev A.
Method for the cancer treatment and prevention of metastatic disease.
PCT/US15/57427
Publications:
1. Nersisyan A., Mett I., Badalyan Z., Kochikyan A., Kocharyan A., Kocharyan Sh.,
Sakanyan V. (1986). Restriction mapping of recombinant plasmids carrying genes for
arginine biosynthesis of Escherichia coli K-12. Genetica, v. 12, 1061-1065.
2. Sakanyan V.A., Hovsepyan A.S., Mett I.L., Kochikyan A.V., Petrosyan P. K. (1990).
Molecular cloning and structural-functional analysis of the arginine biosynthesis genes of
the thermophilic bacterium Bacillus stearothermophilus. Genetica, v. 26, 1915-1925.
3. Sakanyan V., Kochikyan A., Mett I., Legrain C., Charlier D., Pierard,A. and
Glansdorff N.(1992). A re-examination of the path way for ornithine biosynthesis in a
thermophilic and two mesophilic Bacillus species. J. Gen. Microbiology, v. 138, 125-
130.
4. Sakanyan V., Charlier D., Legrain C., Kochikyan A., Mett I., Pierard A. and
Glansdorff N. (1993). Primary structure,partial purification and regulation of key
enzymes of the acetyl cycle of arginine biosynthesis in Bacillus stearothermophilus:dual
function of ornithine acetyltransferase. J. Gen. Microbiol., v. 139, 393-402.
5. Sakanyan V., Desmarez L., Legrain C., Charlier D.,Mett I., Kochikyan A., Savchenko
A., Boyen A., Falmagne P., Pierard A. and Glansdorff N. (1993). Gene cloning,
sequence analysis, purification, and characterization of a thermostable aminoacylase
from Bacillus stearothermophilus. Appl. Environm. Microbiology. v. 59, 3878-3888.
6. Sakanyan V., Legrain C., Charlier D., Kochikyan A., Osyna N. K., Glansdorff N.
(1993). N-acetylglutamate-5-phosphotransferase of thermophilic bacterium Bacillus
stearothermophilus: Nucleotide Sequence and Enzyme Characterization. Genetica,
v.29, 556-569.
7. Zevin-Sonkin D., Liberzon A., Ghochikyan A., Hovhannisyan H., Lvovsky L. and
Ulanovsky L.(1999) DENS (Differential Extension with Nucleotide Subsets) - application
to the sequencing of human genomic DNA and cDNA. DNA Seq.10(4-5):245-54.
8. Panossian A., Kochikian A., Gabrielian E., Muradian R., Stepanian H., Arsenian F.,
Wagner H. (1999). Effect of Andrographis paniculata extract on progesterone in blood
plasma of pregnant rats. Phytomedicine. 6(3) :157-61.
9. Mamikonyan G., Ghochikyan A., Hovhannisyan A., Panossian A., Gabrielian E.,
Wikman G. “Andrographolide binding by blood proteins” Medical Science of Armenia
XLI, 2001, N1, pp 30-34.
10. Ghochikyan, A. Vasilevko, V., Holterman, M.J., Agadjanyan, M.G.
CD80 (B7-1)
and CD86 (B7-2) are Functionally Equivalent in the Initiation and Maintenance of CD4
+
T
cell Proliferation after Activation with Suboptimal Doses of PHA. DNA and cell Biology,
2002, 21, 137-149.
11.Parisot
J.,Ghochikyan
A.,
Langlois
V.,
Sakanyan
V.,
Rabiller
C.
Exopolygalacturonate lyase from Thermotoga maritima: cloning, characterization and
organic synthesis application. Carbohydr Res, 2002, 337(16):1427
12. Ghochikyan A., Miltcheva-Karaivanova I., Lecocq M., Weigel P., Vusio P., Van
Duyne G., Sakanyan V. DNA binding and gene repression in vitro by chimeric proteins
designed from ArgR repressors of Bacillus stearothermophilus and Escherichia coli : the
linker peptide can affect the operator DNA binding specificity. J Bacteriol., 2002, 184
(23):6602-14.
13. Ghochikyan A., Agadjanyan M.G., Cribbs D.H. Different approaches to the
development of vaccine against animal model of Alzheimr’s disease. Neurobiology of
Aging. 2002, 23(1) S237-S237 888 Supl.1.
14. Petrushina I., Tran M., Sadzikava N., Ghochikyan A.,
Vasilevko V., Cribbs H.D, and
Agadjanyan G.M. Importance of detection of murine IgG2c antibodies in APP/Tg 2576
mice immunized with human
amyloid peptide. Neuroscience Letters. 2003, 338(1):5-
8.
15. Cribbs, D.H., Ghochikyan A., Vasilevko, V., Tran, M., Petrushina, I., Sadzikava, N.,
Babikyan D., Kieber-Emmons,T., Agadjanyan, M.G. Adjuvant-dependent modulation of
Th1 and Th2 responses to immunization with -amyloid. Int. Immunol., 2003, 15 :505-
14.
16. Vasilevko V., Ghochikyan A., Sadzikava N., Petrushina I., Tran M., Cohen E.P.,
Kesslak P.J., Cribbs D.H., Agadjanyan M.G. Generation of tumor-specific immune
responses after gene-gun immunization with plasmids, encoding MUC1 and B7
costimulatory molecules. Clin. Exp. Metastas. 2003,20:489-498.
17. Snapyan M., Lecocq M., Guevel L., Arnaud M-C., Ghochikyan A., Sakanyan V.
Dissecting DNA-protein and protein-protein interactions involved in bacterial
transcriptional regulation by a sensitive protein array method combining a near-infrared
fluorescence detection. Proteomics. 2003, 3:647-657.
18. Agadjanyan M., Vasilevko V., Ghochikyan A., Berns P., Kesslak P., Settineri
R.A. and Nicolson G.L. Nutritional Supplement (NT Factor™) Restores Mitochondrial
Function and Reduces Moderately Severe Fatigue in Aged Subjects. Journal of Chronic
Fatigue Syndrome 2003; vol. 11, no. 23-36
19. Ghochikyan
A.,
Vasilevko V., Petrushina I., Movsesyan N., Babikyan D., Tian W.,
Sadzikava N., Ross T., Head L., Cribbs D. & Agadjanyan M. Generation and
characterization of the humoral immune response to DNA immunization with a chimeric
β-amyloid-Interleukin-4 minigene. Eur J Immunol. 2003, 33(12), 3232-41.
20. Gevorkian G., Petrushina I., Manucharian K., Ghochikyan A., Acero G., Vasilevko
V., Cribbs D.H., Agadjanyan M.G. Mimotopes of conformational epitopes in fibrillar beta-
amyloid. J. Neuroimmonol. 2004 256(1-2): 10-20.
21. Agadjanyan M.G., Ghochikyan A., Petrushina I.. Vasilevko V., Movsesyan N.,
Mkrtichyan M., Saing T., Cribbs D.H. Prototype Alzheimer's disease vaccine utilizing the
immunodominant B cell epitope from beta-amyloid and promiscuous T cell epitope
PADRE. J Immunol. 2005, 174 (3):1580-6.
22. Ghochikyan A., Mkrtichyan M., Petrushina I., Movsesyan N., Karapetyan A., Cribbs
D.H., Agadjanyan M.G. Prototype Alzheimer's disease epitope vaccine induced strong
Th2-type anti-Abeta antibody response with Alum to Quil A adjuvant switch.
Vaccine. 2006, 24(13):2275-82.
23. Loukinov D., Ghochikyan A., Mkrtichyan M., Itchim T.E., Lobanenkov V.V., Cribs
.H., Agadjanyan M.G. Antitumor efficacy of DNA vaccination to the epigenetically acting
tumor promoting transcription factor BORIS and CD80 molecular adjuvant.
J Cell Biochem. 2006, 98(5):1037-43.
24. Ghochikyan, A., Petrushina, I., Lees, A., Vasilevko, V., Movsesyan, N., Karapetyan,
A., Agadjanyan,M.G., Cribbs, D.H., Abeta-immunotherapy for Alzheimer's disease using
mannan-amyloid-Beta peptide immunoconjugates 2006. DNA Cell Biol. 2006,
25(10):571-80.
25. Ghochikyan A., Mkrtichyan M., Loukinov D., Mamikonyan G., Pack S.D.,
Movsesyan N., Ichim T.E., Cribbs D.H., Lobanenkov V.V., Agadjanyan M.G. Elicitation
of T Cell Responses to Histologically Unrelated Tumors by Immunization with the Novel
Cancer-Testis Antigen, Brother of the Regulator of Imprinted Sites. J Immunol. 2007,
178, 566-573.
26. Mamikonyan G, Necula M, Mkrtichyan M, Ghochikyan A, Petrushina I, Movsesyan
N, Mina E, Kiyatkin A, Glabe C, Cribbs DH, Agadjanyan MG. Anti-Abeta 1-11 antibody
binds to different beta-amyloid species, inhibits fibril formation, and disaggregates
preformed fibrils, but not the most toxic oligomers. J Biol Chem. 2007 282:22376-86.
27. Petrushina I, Ghochikyan A, Mktrichyan M, Mamikonyan G, Movsesyan N, Davtyan
H, Patel A, Head E, Cribbs DH, Agadjanyan MG. Alzheimer's disease peptide epitope
vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor
protein transgenic mice. J Neurosci. 2007 Nov 14;27(46):12721-31.
28. Mkrtichyan M, Ghochikyan A, Loukinov D, Davtyan H, Ichim TE, Cribbs DH,
Lobanenkov VV, Agadjanyan MG. DNA, but not protein vaccine based on mutated
BORIS antigen significantly inhibits tumor growth and prolongs the survival of mice.
Gene Ther. 2008 Jan;15(1):61-4.
29. Mkrtichyan M, Ghochikyan A, Movsesyan N, Karapetyan A, Begoyan G, Yu J,
Glenn GM, Ross TM, Agadjanyan MG, Cribbs DH. Immunostimulant adjuvant patch
enhances humoral and cellular immune responses to DNA immunization. DNA Cell Biol.
2008 Jan;27(1):19-24.
30. Dougherty CJ, Ichim TE, Liu L, Reznik G, Min WP, Ghochikyan A, Agadjanyan MG,
Reznik BN.Selective apoptosis of breast cancer cells by siRNA targeting of BORIS.
Biochem Biophys Res Commun. 2008 May 23;370(1):109-12.
31. Movsesyan N, Ghochikyan A, Mkrtichyan M, Petrushina I, Davtyan H, Olkhanud
PB, Head E, Biragyn A, Cribbs DH, Agadjanyan MG. Reducing AD-like pathology in
3xTg-AD mouse model by DNA epitope vaccine - a novel immunotherapeutic strategy.
PLoS ONE. 2008 May 7;3(5):e2124.
32. Mamikonyan G, Kiyatkin A, Movsesyan N, Mkrtichyan M, Ghochikyan A, Petrushina
I, Hwang J, Ichim TE, Keledjian H, Agadjanyan MG. Detection of the active components
of calf thymus nuclear proteins (TNP), histones that are binding with high affinity to HIV-
1 envelope proteins and CD4 molecules. Curr HIV Res. 2008 Jun;6(4):318-26.
33. Petrushina I., Ghochikyan A., Mkrtichyan M., Mamikonyan G., Movsesyan G.,
Ajdari R., Vasilevko V., Karapetyan A., Lees A., Agadjanyan MG, Cribbs DH. Mannan-
A
28
conjugate prevented A-plaque deposition, but increased microhemorrhages in the
brains of vaccinated Tg2576 (APPsw) mice. J.Neuroinflammation, 2008 Sep 29;5:42.
34. Movsesyan N, Mkrtichyan M, Petrushina I, Ross T, Cribbs DH, Agadjanyan MG,
Ghochikyan A. Generation of functional anti-amyloid antibodies after immunization with
DNA encoding multiple copies of Aβ-peptide immunogen fused with C3d. Journal of
Neuroimmunology, 2008 Dec 15;205(1-2):57-63 PMCID:PMC2637203
35. Ghochikyan A. Rationale for peptide and DNA based epitope vaccines for
Alzheimer's disease immunotherapy. CNS Neurol Disord Drug Targets. 2009
Apr;8(2):128-43
36. Davtyan H., Mkrtichyan M., Movsesyan N., Petrushina I., Mamikonyan G., Cribbs
DH., Agadjanyan MG., Ghochikyan A. DNA prime/protein boost increased the titer,
avidity and persistence of anti-A antibodies in wild-type mice. Gene Therapy, 2010
Feb; 17, 261–271.
37. Movsesyan N, Davtyan H, Mkrtichyan M, Petrushina I, Tiraturyan T, Ross TM,
Agadjanyan MG, Ghochikyan A, Cribbs DH. Low concentrations of anti-Abeta
antibodies generated in Tg2576 mice by DNA epitope vaccine fused with 3C3d
molecular adjuvant do not affect AD pathology. Hum Gene Ther., 2010, 21(11): 1569-
1576.
38. Robert R, Lefranc MP, Ghochikyan A, Agadjanyan MG, Cribbs DH, Van Nostrand
WE, Wark KL, Dolezal O. Restricted V gene usage and VH/VL pairing of mouse
humoral response against the N-terminal immunodominant epitope of the amyloid β
peptide. Mol Immunol. 2010 Nov-Dec;48 (1-3):59-72.
39. Mkrtichyan M, Ghochikyan A, Davtyan H, Movsesyan N, Loukinov D, Lobanenkov
V, Cribbs DH, Laust AK, Nelson EL, Agadjanyan MG. Cancer-testis antigen, BORIS
based vaccine delivered by dendritic cells is extremely effective against a very
aggressive and highly metastatic mouse mammary carcinoma. Cell Immunol. 2011,
270(2):188-97.
40. Davtyan H, Ghochikyan A, Cadagan R, Zamarin D, Petrushina I, Movsesyan N,
Martinez-Sobrido L, Albrecht RA, García-Sastre A, Agadjanyan MG. The immunological
potency and therapeutic potential of a prototype dual vaccine against influenza and
Alzheimer's disease. J Transl Med. 2011 Aug 1;9:127.
41. de Necochea-Campion R, Ghochikyan A, Josephs SF, Zacharias S, Woods E,
Karimi-Busheri F, Alexandrescu DT, Chen CS, Agadjanyan MG, Carrier E. Expression
of the epigenetic factor BORIS (CTCFL) in the human genome. J Transl Med. 2011 Dec
14;9:213.
42. Davtyan H, Ghochikyan A, Movsesyan N, Ellefsen B, Petrushina I, Cribbs DH,
Hannaman D, Evans CF, Agadjanyan MG. Delivery of a DNA vaccine for Alzheimer’s
disease by electroporation or gene gun generates potent and similar immune
responses. Neurodegenerative Diseases. 2012;10(1-4):261-4.
43. Ghochikyan A., Davtyan H., Petrushina, I, Hovakimyan, A., Movsesyan, N.,
Davtyan, A., Kiyatkin, A., Cribbs, D.H., Agadjanyan, M.G. Refinement of a DNA based
Alzheimer’s disease epitope vaccine in rabbits, Hum Vaccin Immunother. 2013 Feb
11;9(5).
44. Davtyan, H., Ghochikyan, A., Petrushina,I., Hovakimyan, A., Davtyan, A.,
Poghosyan, A., Marleau, A.M., Movsesyan, N., Kiyatkin, A., Rasool, S., Larsen, S.A.,
Madsen, P.J., Wegener, K.M., Ditlevsen, D.K., Cribbs, D.H., Pedersen, L.O.,
Agadjanyan, M.G. Immunogenicity, Efficacy, Safety, and Mechanism of Action of
Epitope Vaccine (Lu AF20513) for Alzheimer’s Disease: Prelude to a Clinical Trial. J.
Neuroscience 2013, Mar 13; 33(11):4923-34.
45. Evans C.F., Davtyan H, Petrushina I., Hovakimyan A., Davtyan A., Hannaman D.,
Cribbs D.H., Agadjanyan M.G., Ghochikyan A. Epitope-based DNA vaccine for
Alzheimer’s disease: translational study in macaques. Alzheimers Dement. 2014
May;10(3):284-95.
46. Ghochikyan A., Petrushina I., Davtyan H., Hovakimyan A., Saing T., Davtyan A.,
Cribbs D.H., Agadjanyan M.G., Immunogenicity of epitope vaccines targeting different B
cell antigenic determinants of human α-synuclein: Feasibility study. Neurosci Lett. 2014
Feb 7;560:86-91.
47. Davtyan H., Bacon A., Petrushina I., Zagorski K., Cribbs D.H., Ghochikyan A.,
Agadjanyan M.G., Immunogenicity of DNA- and recombinant protein-based Alzheimer
Disease Epitope Vaccines. Hum Vaccin Immunother. 2014 Feb 13;10(5):1-8.
48. Ghochikyan A, Davtyan A, Hovakimyan A, Davtyan H, Poghosyan A, Bagaev A,
Ataullakhanov RI, Nelson EL, Agadjanyan MG. Primary 4T1 tumor resection provides
critical "window of opportunity" for immunotherapy. Clin Exp Metastasis. 2014
Feb;31(2):185-98.
49. Davtyan H., Ghochikyan A., Hovakimyan A., Petrushina I., Yu J., Flyer D., Madsen
P.J., Pedersen L.O., Cribbs D.H., Agadjanyan M.G., Immunostimulant patches
containing Escherichia coli LT enhance immune responses to DNA- and recombinant
protein-based Alzheimer's disease vaccines. J Neuroimmunol. 2014 Mar 15; 268 (1-
2):50-7.
50. Davtyan H, Ghochikyan A, Petrushina I., Hovakimyan A., Davtyan A., Cribbs D.H.,
Agadjanyan M.G., MultiTEP platform-based AD epitope vaccine activates broad
repertoire of T helper cells in non-human primates. Alzheimers Dement. 2014 May;
10(3):271-83.
51. Davtyan H, Petrushina I, Ghochikyan A. Immunotherapy for Alzheimer's disease:
DNA- and protein-based epitope vaccines. Methods Mol Biol. 2014; 1143:259-81.
52. Davtyan H, Hovakimyan A., Zagorski K., Davtyan A., Petrushina I., Agdashian D.,
Murthy V., Cribbs D.H., Agadjanyan M.G., Ghochikyan A, BTX AgilePulse
MT
System is
an Effective Electroporation Device for Intramuscular and Intradermal Delivery of DNA
Vaccine. Curr Gene Ther. 2014;14(3):190-9.
53. Ghochikyan A, Pichugin A, Bagaev A, Davtyan A, Hovakimyan A, Tukhvatulin A,
Davtyan H, Shcheblyakov D, Logunov D, Chulkina M, Savilova A, Trofimov D, Nelson
EL, Agadjanyan MG, Ataullakhanov RI. Targeting TLR-4 with a novel pharmaceutical
grade plant derived agonist, Immunomax®, as a therapeutic strategy for metastatic
breast cancer. J Transl Med. 2014 Nov 29;12:322.
54. Davtyan H, Ghochikyan A, Hovakimyan A, Davtyan A, Cadagan R, Marleau AM,
Albrecht RA, García-Sastre A, Agadjanyan MG. A dual vaccine against influenza &
Alzheimer's disease failed to enhance anti-β-amyloid antibody responses in mice with
pre-existing virus specific memory. J Neuroimmunol. 2014 Dec 15;277(1-2):77-84.
55. Agadjanyan MG, Petrovsky N, Ghochikyan A. A fresh perspective from
immunologists and vaccine researchers: Active vaccination strategies to prevent and
reverse Alzheimer's disease. Alzheimers Dement. 2015 Oct;11(10):1246-59.
Conference presentations:
1. Charlier D., Sakanyan V., Kochikyan A., Mett I., Legrain C., Pierard A. and
Glansdorff N. (1992). Organization and expression of arginine biosynthetic genes of
Bacillus stearothermophilus. International Conference "Thermophiles: Science and
Technology" Reikjavik.
2. Sakanyan V., Mett I., Kochikyan A., Savchenko A., Desmarez L., Legrain C.,
Charlier D., Pierard A. and Glansdorff N. (1992). Isolation, sequence and expression in
Escherichia coli of the aminoacylase gen from Bacillus stearothermophilus. International
Conference "Thermophiles: Science and Technology" Reikjavik.
3. Zevin-Sonkin D., Ghochikyan A., Liberzon A., Lvovsky L. and Ulanovsky L.
Sequencing of Human Telomeric Region DNA by Differential Extension with Nucleotide
Subsets (DENS). in: DOE Human Genome Program, Contractor-Grantee Workshop VI,
Santa Fe, NM, Nov 9-13, 1997, p.18.
4. Zevin-Sonkin D., Mugasimangalam R.C., Liberzon A., Ghochikyan A., Hovhannisyan
H., Lvovsky L., Ben-Asher E., Glusman G., Lancet D. and Ulanovsky L. DNA
Sequencing Using Differential Extension with Nucleotide Subsets (DENS): Application to
the Sequencing of Human Genomic DNA. In: Abstracts of papers presented at the 1998
meeting on "Genome mapping, Sequencing and Biology", Cold Spring Harbor
Laboratory, Cold Spring Harbor, NY, 1998, p.242.
5. Cribbs, D.H., Ghochikyan, A., Tran, M., Vasilevko, V., Petrushina, I., Sadzikava, N.,
Patrick Kesslak, Kieber-Emmons, T., Agadjanyan, M.G. Detection of conformational
antigenic determinant in wildtype & APP/TG mice immunized with A 42 peptide.
Presentation on the 8th International Conference on Alzheimer’s Disease and Related
Disorders.Stockholm, Sweden, 2002.
6. Ghochikyan, A., Cribbs, D.H., Agadjanyan, M.G. Different approaches to the
development of vaccine against animal model of Alzhimer’s disease. Presentation on
the
8th
International
Conference
on
Alzheimer’s
Disease
and
Related
Disorders.Stockholm, Sweden, 2002.
7. Ghochikyan, A., Petrushina, I., Tran, M., Sadzikava, N., Vasilevko, V., Cribbs, D.H.,
and Agadjanyan, M.G. Immunization of wildtype and APP/Tg animals with fibrillar Aβ42
induces antibodies to conformational antigenic determinants. Presentation on the
Eighth National Symposium : Basic Aspects of Vaccines. Bethesda, May 1-3, 2002.
8. Vasilevko, V., Tran, M., Petrushina, I., Ghochikyan, A., Kieber-Emmons, T.,
Agadjanyan, M.G., Cribbs, D.H. The role of adjuvant in the humoral and cellular
immune responses to immunization with
-amyloid. . Presentation on the Eighth
National Symposium : Basic Aspects of Vaccines. Bethesda, May 1-3, 2002
9. Gevorkian G., Petrushina I., Ghochikyan A., Manoutcharian K.G., Acero G., Cribbs
D.H., and Agadjanyan M.G. Anti-A
polyclonal sera from wildtype mice recognized
predominantly EFRH epitope. Publication of the Proceedings of the 6th International
Conference on Progress in Alzheimer's and Parkinson's Disease AP / DP (Seville,
Spain,May 8-12, 2003).
10. Cribbs D.H., Lees A., Ghochikyan A., Vasilevko V., Petrushina I., Babikyan D.,
Movsesyan N., Tran M., DeVolger A. and Agadjanyan M.G. Mannan as a Molecular
Adjuvant for Ab- Immunotherapy. Publication of the Proceedings of the 6th International
Conference on Progress in Alzheimer's and Parkinson's Disease AP / DP (Seville,
Spain,May 8-12, 2003).
11. Cribbs D., Lees A., Vasilevko V., Ghochikyan A., Petrushina I., Movsesyan N.,
Agadjanyan M. Alternative strategies for A Immunotherapy using Active Immunization.
12th International Congress of Immunology and 4th Annual Conference on FOCIS.
12. Ghochikyan A.,
Petrushina I.
,
Vasilevko V., Movsesyan N., Mkrtichyan M., Oddo S.,
LaFerla F., Cribbs D. H., Agadjanyan M. G. Peptide epitope vaccine for A
immunotherapy. Presentation on the 10th National Symposium : Basic Aspects of
Vaccines. Bethesda, April 28-30, 2004.
13. Ghochikyan A., Mkrtichyan M., Loukinov D., Mamikonyan G. , Lobanenkov V.,
Cribbs D. H., AgadjanyanM. G.BORIS, Controlling Other Cancer Testis Genes, Induces
Cytotoxic T Cell Responses and Protection Against Poorly Immunogenic, Very
Aggressive, and Highly Metastatic 4T1 Mammary Carcinoma Cells. Translational Imm.
cancer conference. Bethesda, 2005.
14. Ghochikyan A., Mkrtichyan M., Loukinov D., Mamikonyan G., Lobanenkov V.,
Cribbs D. H., Agadjanyan M. G. BORIS, Controlling Other Cancer Testis Genes,
Induces Cytotoxic T Cell Responses and Protection Against Poorly Immunogenic, Very
Aggressive, and Highly Metastatic 4T1 Mammary Carcinoma Cells. Presentation on the
Annual Meeting of The American Association of Immunologidts (AAI), Immunology
Boston, May 12-16, 2006.
15. Ghochikyan A., Movsesyan N., Mkrtichyan M., Mamikonyan G., Petrushina I.,
Cribbs, D. H., Agadjanyan, M.G. DNA-based AD epitope vaccine induced therapeutically
potent anti-A antibodies in AD mouse model. Presentation on the 10th International
Conference on Alzheimer’s Disease and Related Disorders. Madrid, Spain, July 14-21,
2006.
16. Ghochikyan A., Mkrtichyan M., Agadjanyan, M.G. Immunotherapy of Breast
Cancer Based on a Novel Tumor Associated Antigen, BORIS. 3
rd
International
Conference on CTCF/Boris. S. Carolina, May, 2006.
17. Ghochikyan, A., Movsesyan, N., Mkrtichyan, M., Petrushina, I., Biragyn, A., Cribbs,
D. H., Agadjanyan, M.G. DNA epitope vaccine induced strong anti-A antibodies
inhibiting AD like pathology in 3xTg-AD mice and protecting them from cognitive decline.
8th International Conference AD/PD, Salzburg, Austria, March 14-18, 2007.
18. Ghochikyan, A., Movsesyan, N., Mkrtichyan, M., Petrushina, I., Arya Biragyn,
Cribbs, D. H., Agadjanyan, M.G. DNA epitope vaccine prevents AD like pathology in
3xTg-AD mice and protects them from cognitive decline. International Conference on
Prevention of Dementia. Washington, DC, June 9-12, 2007.
19. Ghochikyan A., Martinez L., Movsesyan N., Mkrtichyan M., Petrushina I., Davtyan
H., Cribbs D.H., García-Sastre A., Agadjanyan M.G. The novel strategy for generation
of effective and safe Alzheimer’s Disease vaccine based on conventional influenza virus
vaccine modified to express Aβ
1-11
. International Conference on Prevention of Dementia.
Chicago, IL, 2008.
20. Ghochikyan, A., PhD, Davtyan, H., PhD, Movsesyan, N., PhD, Mkrtichyan, M.,
PhD; Petrushina, I. Ph.D., Cribbs, D. H., PhD., Agadjanyan, M.G., PhD. Third
generation epitope vaccine (EV): A new Strategy for A immunotherapy. 9th
International Conference AD/PD, Prague, Czech Republic, March 11-15, 2009.
21. Ghochikyan A., Davtyan H., Movsesyan N., Mkrtichyan M., Petrushina I., Cribbs
D.H., Agadjanyan M.G. Induction of rapid and robust anti-Aβ antibody production by
reactivation of pre-existing memory Th cells generated from conventional vaccines.
Presentation on the International Conference on Alzheimer’s Disease. Vienna, Austria,
July 11-16, 2009.
22. Mkrtichyan M., Khlghatyan J., Loukinov D., Movsesyan N., Davtyan H.,
Ghochikyan A., Agadjanyan M.G. DNA vaccine based on cancer-testis antigen, BORIS
and IL21 molecular adjuvant is extremely effective for treatment of metastatic disease.
DNA Vaccine International Conference. New Orleans, USA, March 2-4, 2010.
23. Davtyan H., Mkrtichyan M., Movsesyan N., Petrushina I., Mamikonyan G., Cribbs
D.H., Agadjanyan M.G., Ghochikyan A. Improvement of Alzheimer’s Disease (AD)
DNA vaccine efficacy by DNA prime/protein boost regimen in mice and rabbits
DNA Vaccine International Conference. New Orleans, USA, March 2-4, 2010.
24. Davtyan H., Ghochikyan A., Albrecht R.A., Movsesyan
N., Petrushina I., Cribbs
D.H., García-Sastre A., Agadjanyan M.G. The novel strategy for generation of effctive
and safe Alzheimer's disease vaccine based on conventional Influenza virus vaccine
modified to express Aβ
1-10
. 10
th
International Conference AD/PD, Barcelona, Spain,
March 6-10, 2011.
25. Davtyan H., Ghochikyan A., Petrushina I., Hovakimyan A., Davtyan A., Poghosyan
A., Cribbs D.H., Agadjanyan M.G. Multiple approaches to immunotherapy against
Alzheimer’s disease. "Brain Waves" Alz Symposium, Santa Barbara, April 19, 2012.
26. Davtyan H., Ghochikyan A., Petrushina I., Hovakimyan A., Movsesyan
N., Kiyatkin
A., Evans C.,, Hannaman D., Cribbs D.H., Agadjanyan M.G. Translational study:
refinement of DNA based Alzheimer's disease (AD) epitope vaccine in rabbits.
Alzheimer's Association International Conference (AAIC), Vancouver, Canada, July 14-
19, 2012.
27. Davtyan A., Ghochikyan A., Hovakimyan A., Davtyan H., Poghosyan A., Bagaev A.,
Ataullakhanov R.I., Nelson E.L., Agadjanyan M.G. Primary breast 4T1 tumor resection
model for the testing for anti-cancer therapeutics. X Immunology Fair, UCI, Irvine, CA,
November 15-16, 2012.
28. Ghochikyan A., Davtyan H., Petrushina I., Hovakimyan A., Davtyan A., Movsesyan
N., Kiyatkin A., Hannaman D., Evans C.F., Cribbs D.H., Agadjanyan M.G. Refinement of
Alzheimer’s Disease DNA-based epitope vaccine: broad coverage of MHC
polymorphism and targeting pre-existing memory T cells. 11
th
International Conference
AD/PD, Florence, Italy, March 6-10, 2013.
29. Davtyan H., Petrushina I., Evans C.F., Hovakimyan A., Davtyan A., Hannaman D.,
Cribbs D.H., Ghochikyan A., Agadjanyan M.G. MultiTEP platform based AD vaccine
immunogenic in rabbits and monkeys. Clinical Trials on Alzheimer’s Disease (CTAD),
San Diego, CA, November 14-16, 2013.
30. Amado A.J. Davtyan H., Serraneau K., Zagorski K., Gordon M. N., Cribbs D.H.
Ghochikyan A., Petrovsky N., Agadjanyan M. G., Morgan D.
Active immunization with
highly immunogenic tau epitope induced a strong immune response together with
improvement in short memory but failed to significantly reduce tau pathology in a mouse
model of tauopathy. Neuroscience, Chicago, IL, October 17-21, 2015
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